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Literature DB >> 22265401

Aging, rejuvenation, and epigenetic reprogramming: resetting the aging clock.

Abstract

The underlying cause of aging remains one of the central mysteries of biology. Recent studies in several different systems suggest that not only may the rate of aging be modified by environmental and genetic factors, but also that the aging clock can be reversed, restoring characteristics of youthfulness to aged cells and tissues. This Review focuses on the emerging biology of rejuvenation through the lens of epigenetic reprogramming. By defining youthfulness and senescence as epigenetic states, a framework for asking new questions about the aging process emerges.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2012 PMID： 22265401 PMCID： PMC3336960 DOI： 10.1016/j.cell.2012.01.003

Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582

112 in total

1. Recreating pluripotency?

Authors: Kyle M Loh; Bing Lim
Journal: Cell Stem Cell Date: 2010-08-06 Impact factor: 24.633

2. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Authors: Raul Mostoslavsky; Katrin F Chua; David B Lombard; Wendy W Pang; Miriam R Fischer; Lionel Gellon; Pingfang Liu; Gustavo Mostoslavsky; Sonia Franco; Michael M Murphy; Kevin D Mills; Parin Patel; Joyce T Hsu; Andrew L Hong; Ethan Ford; Hwei-Ling Cheng; Caitlin Kennedy; Nomeli Nunez; Roderick Bronson; David Frendewey; Wojtek Auerbach; David Valenzuela; Margaret Karow; Michael O Hottiger; Stephen Hursting; J Carl Barrett; Leonard Guarente; Richard Mulligan; Bruce Demple; George D Yancopoulos; Frederick W Alt
Journal: Cell Date: 2006-01-27 Impact factor: 41.582

3. Molecular coupling of Xist regulation and pluripotency.

Authors: Pablo Navarro; Ian Chambers; Violetta Karwacki-Neisius; Corinne Chureau; Céline Morey; Claire Rougeulle; Philip Avner
Journal: Science Date: 2008-09-19 Impact factor: 47.728

4. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors: M Kaeberlein; M McVey; L Guarente
Journal: Genes Dev Date: 1999-10-01 Impact factor: 11.361

5. Systematic identification of cis-silenced genes by trans complementation.

Authors: Jae Hyun Lee; Branimir Bugarija; Enrique J Millan; Noah M Walton; Jedidiah Gaetz; Croydon J Fernandes; Wei-Hua Yu; Nitzan Mekel-Bobrov; Tammy W Vallender; Gregory E Snyder; Andy Peng Xiang; Bruce T Lahn
Journal: Hum Mol Genet Date: 2008-12-02 Impact factor: 6.150

6. Bmi-1 regulates the Ink4a/Arf locus to control pancreatic beta-cell proliferation.

Authors: Sangeeta Dhawan; Shuen-Ing Tschen; Anil Bhushan
Journal: Genes Dev Date: 2009-04-15 Impact factor: 11.361

Review 7. The role of nuclear architecture in genomic instability and ageing.

Authors: Philipp Oberdoerffer; David A Sinclair
Journal: Nat Rev Mol Cell Biol Date: 2007-09 Impact factor: 94.444

8. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway.

Authors: Pankaj Kapahi; Brian M Zid; Tony Harper; Daniel Koslover; Viveca Sapin; Seymour Benzer
Journal: Curr Biol Date: 2004-05-25 Impact factor: 10.834

9. Transgenerational epigenetic inheritance of longevity in Caenorhabditis elegans.

Authors: Eric L Greer; Travis J Maures; Duygu Ucar; Anna G Hauswirth; Elena Mancini; Jana P Lim; Bérénice A Benayoun; Yang Shi; Anne Brunet
Journal: Nature Date: 2011-10-19 Impact factor: 49.962

Review 10. The DNA damage response: Balancing the scale between cancer and ageing.

Authors: Elena G Seviour; Shiaw-Yin Lin
Journal: Aging (Albany NY) Date: 2010-12 Impact factor: 5.682

185 in total

1. Uncovering the role of genomic "dark matter" in human disease.

Authors: Lance Martin; Howard Y Chang
Journal: J Clin Invest Date: 2012-05-01 Impact factor: 14.808

2. NF-κB inhibition delays DNA damage-induced senescence and aging in mice.

Authors: Jeremy S Tilstra; Andria R Robinson; Jin Wang; Siobhán Q Gregg; Cheryl L Clauson; Daniel P Reay; Luigi A Nasto; Claudette M St Croix; Arvydas Usas; Nam Vo; Johnny Huard; Paula R Clemens; Donna B Stolz; Denis C Guttridge; Simon C Watkins; George A Garinis; Yinsheng Wang; Laura J Niedernhofer; Paul D Robbins
Journal: J Clin Invest Date: 2012-06-18 Impact factor: 14.808

Review 3. The place of genetics in ageing research.

Authors: Nir Barzilai; Leonard Guarente; Thomas B L Kirkwood; Linda Partridge; Thomas A Rando; P Eline Slagboom
Journal: Nat Rev Genet Date: 2012-07-10 Impact factor: 53.242

4. NF-κB activation impairs somatic cell reprogramming in ageing.

Authors: Clara Soria-Valles; Fernando G Osorio; Ana Gutiérrez-Fernández; Alejandro De Los Angeles; Clara Bueno; Pablo Menéndez; José I Martín-Subero; George Q Daley; José M P Freije; Carlos López-Otín
Journal: Nat Cell Biol Date: 2015-07-27 Impact factor: 28.824

5. Direct Lineage Reprogramming Reveals Disease-Specific Phenotypes of Motor Neurons from Human ALS Patients.

Authors: Meng-Lu Liu; Tong Zang; Chun-Li Zhang
Journal: Cell Rep Date: 2015-12-24 Impact factor: 9.423

Review 6. The aging hematopoietic stem cell niche: Phenotypic and functional changes and mechanisms that contribute to hematopoietic aging.

Authors: Sarah E Latchney; Laura M Calvi
Journal: Semin Hematol Date: 2016-10-19 Impact factor: 3.851