Literature DB >> 22777128

The place of genetics in ageing research.

Nir Barzilai1, Leonard Guarente, Thomas B L Kirkwood, Linda Partridge, Thomas A Rando, P Eline Slagboom.   

Abstract

Rapidly increasing numbers of older people present many countries with growing social and economic challenges. Yet despite the far-reaching implications of ageing, its biological basis remains a topic of much debate. Recent advances in genomics have spurred research on ageing and lifespan in human populations, adding to extensive genetic studies being carried out in model organisms. But how far is ageing controlled by our genes? In this Viewpoint, six experts present their opinions and comment on future directions in ageing research.

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Year:  2012        PMID: 22777128     DOI: 10.1038/nrg3290

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN: 1471-0056            Impact factor:   53.242


  60 in total

Review 1.  Is aging programed?

Authors:  Steven N Austad
Journal:  Aging Cell       Date:  2004-10       Impact factor: 9.304

Review 2.  The biology of aging: 1985-2010 and beyond.

Authors:  George M Martin
Journal:  FASEB J       Date:  2011-11       Impact factor: 5.191

Review 3.  On the programmed/non-programmed nature of ageing within the life history.

Authors:  Thomas B L Kirkwood; Simon Melov
Journal:  Curr Biol       Date:  2011-09-27       Impact factor: 10.834

4.  Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction.

Authors:  Joan C Murphy; Jennifer L McDaniel; Katherine Mora; Dennis T Villareal; Luigi Fontana; Edward P Weiss
Journal:  J Appl Physiol (1985)       Date:  2011-10-20

5.  Speed-bumps ahead for the genetics of later-life diseases.

Authors:  Thomas B L Kirkwood; Heather J Cordell; Caleb E Finch
Journal:  Trends Genet       Date:  2011-08-06       Impact factor: 11.639

6.  The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms.

Authors:  M Kaeberlein; M McVey; L Guarente
Journal:  Genes Dev       Date:  1999-10-01       Impact factor: 11.361

7.  Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors:  Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Journal:  Nature       Date:  2003-08-24       Impact factor: 49.962

8.  The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900.

Authors:  A M Herskind; M McGue; N V Holm; T I Sørensen; B Harvald; J W Vaupel
Journal:  Hum Genet       Date:  1996-03       Impact factor: 4.132

9.  Association of a functional polymorphism in the cholesteryl ester transfer protein (CETP) gene with memory decline and incidence of dementia.

Authors:  Amy E Sanders; Cuiling Wang; Mindy Katz; Carol A Derby; Nir Barzilai; Laurie Ozelius; Richard B Lipton
Journal:  JAMA       Date:  2010-01-13       Impact factor: 56.272

10.  Epigenetic variation during the adult lifespan: cross-sectional and longitudinal data on monozygotic twin pairs.

Authors:  Rudolf P Talens; Kaare Christensen; Hein Putter; Gonneke Willemsen; Lene Christiansen; Dennis Kremer; H Eka D Suchiman; P Eline Slagboom; Dorret I Boomsma; Bastiaan T Heijmans
Journal:  Aging Cell       Date:  2012-06-04       Impact factor: 9.304

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  19 in total

1.  The Longitudinal Study of Aging in Human Young Adults: Knowledge Gaps and Research Agenda.

Authors:  Terrie E Moffitt; Daniel W Belsky; Andrea Danese; Richie Poulton; Avshalom Caspi
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2016-10-07       Impact factor: 6.053

2.  Activation-Induced Autophagy Is Preserved in CD4+ T-Cells in Familial Longevity.

Authors:  Yotam Raz; Ignacio Guerrero-Ros; Andrea Maier; P Eline Slagboom; Gil Atzmon; Nir Barzilai; Fernando Macian
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2017-09-01       Impact factor: 6.053

Review 3.  Perspectives on pharmacogenomics of antiretroviral medications and HIV-associated comorbidities.

Authors:  David W Haas; Philip E Tarr
Journal:  Curr Opin HIV AIDS       Date:  2015-03       Impact factor: 4.283

Review 4.  Recent Advances in the Systems Biology of Aging.

Authors:  Mark A McCormick; Daniel E L Promislow
Journal:  Antioxid Redox Signal       Date:  2017-11-20       Impact factor: 8.401

5.  How Genes Modulate Patterns of Aging-Related Changes on the Way to 100: Biodemographic Models and Methods in Genetic Analyses of Longitudinal Data.

Authors:  Anatoliy I Yashin; Konstantin G Arbeev; Deqing Wu; Liubov Arbeeva; Alexander Kulminski; Irina Kulminskaya; Igor Akushevich; Svetlana V Ukraintseva
Journal:  N Am Actuar J       Date:  2016-06-22

6.  The free radical theory of aging is dead. Long live the damage theory!

Authors:  Vadim N Gladyshev
Journal:  Antioxid Redox Signal       Date:  2013-12-04       Impact factor: 8.401

Review 7.  Membrane ion Channels and Receptors in Animal lifespan Modulation.

Authors:  Yi Sheng; Lanlan Tang; Lijun Kang; Rui Xiao
Journal:  J Cell Physiol       Date:  2017-02-03       Impact factor: 6.384

8.  Quantification of biological aging in young adults.

Authors:  Daniel W Belsky; Avshalom Caspi; Renate Houts; Harvey J Cohen; David L Corcoran; Andrea Danese; HonaLee Harrington; Salomon Israel; Morgan E Levine; Jonathan D Schaefer; Karen Sugden; Ben Williams; Anatoli I Yashin; Richie Poulton; Terrie E Moffitt
Journal:  Proc Natl Acad Sci U S A       Date:  2015-07-06       Impact factor: 11.205

9.  In Vivo Quasi-Elastic Light Scattering Eye Scanner Detects Molecular Aging in Humans.

Authors:  Olga Minaeva; Srikant Sarangi; Danielle M Ledoux; Juliet A Moncaster; Douglas S Parsons; Kevin J Washicosky; Caitlin A Black; Frank J Weng; Maria Ericsson; Robert D Moir; Yorghos Tripodis; John I Clark; Rudolph E Tanzi; David G Hunter; Lee E Goldstein
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2020-09-16       Impact factor: 6.053

Review 10.  Epigenetic determinants of healthy and diseased brain aging and cognition.

Authors:  Schahram Akbarian; Michal Schnaider Beeri; Vahram Haroutunian
Journal:  JAMA Neurol       Date:  2013-06       Impact factor: 18.302

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