BACKGROUND: Cancer cachexia is a devastating condition leading to loss of function and independence, decreased performance status, decreased quality of life, and poor prognosis. Adipokines play a role in a wide variety of physiological or pathological processes, including immunity and inflammation, in addition to having significant effects on metabolism and lipogenesis. The objective of the present study was to investigate the relationship of adipokines and systemic inflammation in weight-losing advanced-stage non-small-cell lung cancer (NSCLC) patients. METHODS: Sixty-three male NSCLC patients (stages III and IV) and 25 age- and sex-matched controls were included. NSCLC patients were further divided into subgroups as those with a>5% weight loss in last 6 months and those who did not. Serum leptin, adiponectin, and TNF-α concentrations were measured by ELISA using commercially available kits. RESULTS: The positive acute-phase reactants (APR) CRP, leukocyte, ferritin, thrombocyte, and fibrinogen were higher in the NSCLC group. Serum albumin level (which is a negative APR) was lower in the cancer group, whereas there was no difference in transferrin level between the groups. TNF-α and leptin concentrations were similar in the cancer group and the control group, whereas adiponectin was lower in the cancer group. There was a difference in thrombocyte and transferrin levels between patients with and without weight loss, whereas CRP, TNF-α, and adiponectin levels were similar. Leptin was lower in weight-losing cancer patients. However, there was no correlation between adipokines and markers of systemic inflammation. CONCLUSION: These results revealed a lack of association between adipokine levels and systemic inflammation with cancer cachexia.
BACKGROUND:Cancer cachexia is a devastating condition leading to loss of function and independence, decreased performance status, decreased quality of life, and poor prognosis. Adipokines play a role in a wide variety of physiological or pathological processes, including immunity and inflammation, in addition to having significant effects on metabolism and lipogenesis. The objective of the present study was to investigate the relationship of adipokines and systemic inflammation in weight-losing advanced-stage non-small-cell lung cancer (NSCLC) patients. METHODS: Sixty-three male NSCLCpatients (stages III and IV) and 25 age- and sex-matched controls were included. NSCLCpatients were further divided into subgroups as those with a>5% weight loss in last 6 months and those who did not. Serum leptin, adiponectin, and TNF-α concentrations were measured by ELISA using commercially available kits. RESULTS: The positive acute-phase reactants (APR) CRP, leukocyte, ferritin, thrombocyte, and fibrinogen were higher in the NSCLC group. Serum albumin level (which is a negative APR) was lower in the cancer group, whereas there was no difference in transferrin level between the groups. TNF-α and leptin concentrations were similar in the cancer group and the control group, whereas adiponectin was lower in the cancer group. There was a difference in thrombocyte and transferrin levels between patients with and without weight loss, whereas CRP, TNF-α, and adiponectin levels were similar. Leptin was lower in weight-losing cancerpatients. However, there was no correlation between adipokines and markers of systemic inflammation. CONCLUSION: These results revealed a lack of association between adipokine levels and systemic inflammation with cancer cachexia.
Authors: G Mantovani; A Macciò; C Madeddu; L Mura; E Massa; M C Mudu; C Mulas; M R Lusso; G Gramignano; M B Piras Journal: J Mol Med (Berl) Date: 2001-07 Impact factor: 4.599
Authors: Miguel Otero; Rocío Lago; Francisca Lago; Felipe F Casanueva; Carlos Dieguez; Juan Jesús Gómez-Reino; Oreste Gualillo Journal: FEBS Lett Date: 2005-01-17 Impact factor: 4.124
Authors: B Ghanim; M A Hoda; T Klikovits; M-P Winter; A Alimohammadi; M Grusch; B Dome; M Arns; P Schenk; M Jakopovic; M Samarzija; L Brcic; M Filipits; V Laszlo; W Klepetko; W Berger; B Hegedus Journal: Br J Cancer Date: 2014-01-16 Impact factor: 7.640
Authors: Nelson Inácio Pinto; June Carnier; Lila M Oyama; Jose Pinhata Otoch; Paulo Sergio Alcântara; Flavio Tokeshi; Claudia M Nascimento Journal: Mediators Inflamm Date: 2015-10-05 Impact factor: 4.711