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Literature DB >> 22241279

Spontaneous inter-conversion of insulin fibril chirality.

Dmitry Kurouski¹, Rina K Dukor, Xuefang Lu, Laurence A Nafie, Igor K Lednev.

Abstract

Amyloid fibrils are associated with many neurodegenerative diseases and are considered to be the energetically most favorable form of proteins. Here we report that a small pH change initiates spontaneous transformation of insulin fibrils from one polymorph to another. As a result, fibril supramolecular chirality overturns both accompanying morphological and structural changes.

Entities: Chemical Disease Gene

Mesh：

Substances：
Amyloid
Insulin

Year: 2012 PMID： 22241279 PMCID： PMC3655902 DOI： 10.1039/c2cc16895b

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

21 in total

1. Direct observation and pH control of reversed supramolecular chirality in insulin fibrils by vibrational circular dichroism.

Authors: Dmitry Kurouski; Rosina A Lombardi; Rina K Dukor; Igor K Lednev; Laurence A Nafie
Journal: Chem Commun (Camb) Date: 2010-09-01 Impact factor: 6.222

2. Amyloid fibrils are "alive": spontaneous refolding from one polymorph to another.

Authors: Dmitry Kurouski; William Lauro; Igor K Lednev
Journal: Chem Commun (Camb) Date: 2010-01-27 Impact factor: 6.222

Review 3. From the polymorphism of amyloid fibrils to their assembly mechanism and cytotoxicity.

Authors: Laurent Kreplak; Ueli Aebi
Journal: Adv Protein Chem Date: 2006

4. Conformational indeterminism in protein misfolding: chiral amplification on amyloidogenic pathway of insulin.

Authors: Wojciech Dzwolak; Anna Loksztejn; Agnieszka Galinska-Rakoczy; Rumi Adachi; Yuji Goto; Leszek Rupnicki
Journal: J Am Chem Soc Date: 2007-05-23 Impact factor: 15.419

5. Vibrational circular dichroism shows unusual sensitivity to protein fibril formation and development in solution.

Authors: Shengli Ma; Xiaolin Cao; Mimi Mak; Adeola Sadik; Christoph Walkner; Teresa B Freedman; Igor K Lednev; Rina K Dukor; Laurence A Nafie
Journal: J Am Chem Soc Date: 2007-09-26 Impact factor: 15.419

6. Probing the cross-beta core structure of amyloid fibrils by hydrogen-deuterium exchange deep ultraviolet resonance Raman spectroscopy.

Authors: Ming Xu; Victor Shashilov; Igor K Lednev
Journal: J Am Chem Soc Date: 2007-08-18 Impact factor: 15.419

7. Hen egg white lysozyme fibrillation: a deep-UV resonance Raman spectroscopic study.

Authors: Ming Xu; Vladimir V Ermolenkov; Vladimir N Uversky; Igor K Lednev
Journal: J Biophotonics Date: 2008-08 Impact factor: 3.207

8. Genetic engineering combined with deep UV resonance Raman spectroscopy for structural characterization of amyloid-like fibrils.

Authors: Vitali Sikirzhytski; Natalya I Topilina; Seiichiro Higashiya; John T Welch; Igor K Lednev
Journal: J Am Chem Soc Date: 2008-04-15 Impact factor: 15.419

9. The component polypeptide chains of bovine insulin nucleate or inhibit aggregation of the parent protein in a conformation-dependent manner.

Authors: Glyn L Devlin; Tuomas P J Knowles; Adam Squires; Margaret G McCammon; Sally L Gras; Melanie R Nilsson; Carol V Robinson; Christopher M Dobson; Cait E MacPhee
Journal: J Mol Biol Date: 2006-05-17 Impact factor: 5.469

10. Chiral bifurcation in aggregating insulin: an induced circular dichroism study.

Authors: Anna Loksztejn; Wojciech Dzwolak
Journal: J Mol Biol Date: 2008-04-03 Impact factor: 5.469

15 in total

Review 1. Understanding amyloid fibril formation using protein fragments: structural investigations via vibrational spectroscopy and solid-state NMR.

Authors: Benjamin Martial; Thierry Lefèvre; Michèle Auger
Journal: Biophys Rev Date: 2018-05-31

2. Normal and reversed supramolecular chirality of insulin fibrils probed by vibrational circular dichroism at the protofilament level of fibril structure.

Authors: Dmitry Kurouski; Rina K Dukor; Xuefang Lu; Laurence A Nafie; Igor K Lednev
Journal: Biophys J Date: 2012-08-08 Impact factor: 4.033

3. Structure and composition of insulin fibril surfaces probed by TERS.

Authors: Dmitry Kurouski; Tanja Deckert-Gaudig; Volker Deckert; Igor K Lednev
Journal: J Am Chem Soc Date: 2012-08-03 Impact factor: 15.419

4. Amyloid fibrils: the eighth wonder of the world in protein folding and aggregation.

Authors: Igor K Lednev
Journal: Biophys J Date: 2014-04-01 Impact factor: 4.033

5. Ultraviolet Resonance Raman Spectroscopic Markers for Protein Structure and Dynamics.

Authors: Ryan S Jakubek; Joseph Handen; Stephen E White; Sanford A Asher; Igor K Lednev
Journal: Trends Analyt Chem Date: 2017-12-11 Impact factor: 12.296

Review 6. Formation and properties of amyloid fibrils of prion protein.

Authors: Kei-Ichi Yamaguchi; Kazuo Kuwata
Journal: Biophys Rev Date: 2017-12-04

7. Surface characterization of insulin protofilaments and fibril polymorphs using tip-enhanced Raman spectroscopy (TERS).

Authors: Dmitry Kurouski; Tanja Deckert-Gaudig; Volker Deckert; Igor K Lednev
Journal: Biophys J Date: 2014-01-07 Impact factor: 4.033