Literature DB >> 23583713

Levels of supramolecular chirality of polyglutamine aggregates revealed by vibrational circular dichroism.

Dmitry Kurouski1, Karunakar Kar, Ronald Wetzel, Rina K Dukor, Igor K Lednev, Laurence A Nafie.   

Abstract

Polyglutamine (PolyQ) aggregates are a hallmark of several severe neurodegenerative diseases, expanded CAG-repeat diseases in which inheritance of an expanded polyQ sequence above a pathological threshold is associated with a high risk of disease. Application of vibrational circular dichroism (VCD) reveals that these PolyQ fibril aggregates exhibit a chiral supramolecular organization that is distinct from the supramolecular organization of previously observed amyloid fibrils. PolyQ fibrils grown from monomers with Q repeats 35 and above (Q≥35) exhibit approximately 10-fold enhancement of the same VCD spectrum compared to the already enhanced VCD of fibrils formed from Q repeats 30 and below (Q≤30).
Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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Year:  2013        PMID： 23583713      PMCID： PMC3685276          DOI： 10.1016/j.febslet.2013.03.038

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  33 in total

1.  Vibrational circular-dichroism spectroscopy of homologous cyclic peptides designed to fold into β helices of opposite chirality.

Authors:  John L Kulp; Jeffrey C Owrutsky; Dmitri Y Petrovykh; Kenan P Fears; Rosina Lombardi; Laurence A Nafie; Thomas D Clark
Journal:  Biointerphases       Date:  2011-03       Impact factor: 2.456

2.  Normal and reversed supramolecular chirality of insulin fibrils probed by vibrational circular dichroism at the protofilament level of fibril structure.

Authors:  Dmitry Kurouski; Rina K Dukor; Xuefang Lu; Laurence A Nafie; Igor K Lednev
Journal:  Biophys J       Date:  2012-08-08       Impact factor: 4.033

3.  UV resonance Raman spectroscopy monitors polyglutamine backbone and side chain hydrogen bonding and fibrillization.

Authors:  Kan Xiong; David Punihaole; Sanford A Asher
Journal:  Biochemistry       Date:  2012-07-12       Impact factor: 3.162

4.  Spontaneous inter-conversion of insulin fibril chirality.

Authors:  Dmitry Kurouski; Rina K Dukor; Xuefang Lu; Laurence A Nafie; Igor K Lednev
Journal:  Chem Commun (Camb)       Date:  2012-01-12       Impact factor: 6.222

5.  Polyglutamine aggregation behavior in vitro supports a recruitment mechanism of cytotoxicity.

Authors:  S Chen; V Berthelier; W Yang; R Wetzel
Journal:  J Mol Biol       Date:  2001-08-03       Impact factor: 5.469

6.  Architecture and polymorphism of fibrillar supramolecular assemblies produced by in vitro aggregation of human calcitonin.

Authors:  H H Bauer; U Aebi; M Häner; R Hermann; M Müller; H P Merkle
Journal:  J Struct Biol       Date:  1995 Jul-Aug       Impact factor: 2.867

7.  New model for crystalline polyglutamine assemblies and their connection with amyloid fibrils.

Authors:  Pawel Sikorski; Edward Atkins
Journal:  Biomacromolecules       Date:  2005 Jan-Feb       Impact factor: 6.988

8.  Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments.

Authors:  Murali Jayaraman; Ravindra Kodali; Bankanidhi Sahoo; Ashwani K Thakur; Anand Mayasundari; Rakesh Mishra; Cynthia B Peterson; Ronald Wetzel
Journal:  J Mol Biol       Date:  2011-12-09       Impact factor: 5.469

9.  Critical nucleus size for disease-related polyglutamine aggregation is repeat-length dependent.

Authors:  Karunakar Kar; Murali Jayaraman; Bankanidhi Sahoo; Ravindra Kodali; Ronald Wetzel
Journal:  Nat Struct Mol Biol       Date:  2011-02-13       Impact factor: 15.369

10.  Aggregated polyglutamine peptides delivered to nuclei are toxic to mammalian cells.

Authors:  Wen Yang; John R Dunlap; Richard B Andrews; Ronald Wetzel
Journal:  Hum Mol Genet       Date:  2002-11-01       Impact factor: 6.150
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  7 in total

1.  Protofilament Structure and Supramolecular Polymorphism of Aggregated Mutant Huntingtin Exon 1.

Authors:  Jennifer C Boatz; Talia Piretra; Alessia Lasorsa; Irina Matlahov; James F Conway; Patrick C A van der Wel
Journal:  J Mol Biol       Date:  2020-06-27       Impact factor: 5.469

Review 2.  Understanding amyloid fibril formation using protein fragments: structural investigations via vibrational spectroscopy and solid-state NMR.

Authors:  Benjamin Martial; Thierry Lefèvre; Michèle Auger
Journal:  Biophys Rev       Date:  2018-05-31

3.  Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation.

Authors:  Elodie Monsellier; Virginie Redeker; Gemma Ruiz-Arlandis; Luc Bousset; Ronald Melki
Journal:  J Biol Chem       Date:  2014-12-10       Impact factor: 5.157

4.  Biophysical underpinnings of the repeat length dependence of polyglutamine amyloid formation.

Authors:  Elizabeth Landrum; Ronald Wetzel
Journal:  J Biol Chem       Date:  2014-03-04       Impact factor: 5.157

5.  Is supramolecular filament chirality the underlying cause of major morphology differences in amyloid fibrils?

Authors:  Dmitry Kurouski; Xuefang Lu; Ludmila Popova; William Wan; Maruda Shanmugasundaram; Gerald Stubbs; Rina K Dukor; Igor K Lednev; Laurence A Nafie
Journal:  J Am Chem Soc       Date:  2014-01-31       Impact factor: 15.419

6.  Inversion of Supramolecular Chirality by Sonication-Induced Organogelation.

Authors:  Sibaprasad Maity; Priyadip Das; Meital Reches
Journal:  Sci Rep       Date:  2015-11-10       Impact factor: 4.379

7.  Spatially resolved spectroscopic differentiation of hydrophilic and hydrophobic domains on individual insulin amyloid fibrils.

Authors:  Tanja Deckert-Gaudig; Dmitry Kurouski; Martin A B Hedegaard; Pushkar Singh; Igor K Lednev; Volker Deckert
Journal:  Sci Rep       Date:  2016-09-21       Impact factor: 4.379
  7 in total

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