Literature DB >> 20820535

Direct observation and pH control of reversed supramolecular chirality in insulin fibrils by vibrational circular dichroism.

Dmitry Kurouski1, Rosina A Lombardi, Rina K Dukor, Igor K Lednev, Laurence A Nafie.   

Abstract

The controlled reversal of supramolecular helical chirality in protein fibrils is reported for the first time. Normal or reversed insulin fibrils were grown by precise adjustment of pH. AFM images show two polymorphs corresponding to opposite senses of helical twist of the supramolecular structure with the same cross-β-sheet core.

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Year:  2010        PMID： 20820535     DOI： 10.1039/c0cc02423f

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  14 in total

1.  Normal and reversed supramolecular chirality of insulin fibrils probed by vibrational circular dichroism at the protofilament level of fibril structure.

Authors:  Dmitry Kurouski; Rina K Dukor; Xuefang Lu; Laurence A Nafie; Igor K Lednev
Journal:  Biophys J       Date:  2012-08-08       Impact factor: 4.033

2.  Infrared and Raman chemical imaging and spectroscopy at the nanoscale.

Authors:  Dmitry Kurouski; Alexandre Dazzi; Renato Zenobi; Andrea Centrone
Journal:  Chem Soc Rev       Date:  2020-05-19       Impact factor: 54.564

3.  Spontaneous inter-conversion of insulin fibril chirality.

Authors:  Dmitry Kurouski; Rina K Dukor; Xuefang Lu; Laurence A Nafie; Igor K Lednev
Journal:  Chem Commun (Camb)       Date:  2012-01-12       Impact factor: 6.222

4.  Surface characterization of insulin protofilaments and fibril polymorphs using tip-enhanced Raman spectroscopy (TERS).

Authors:  Dmitry Kurouski; Tanja Deckert-Gaudig; Volker Deckert; Igor K Lednev
Journal:  Biophys J       Date:  2014-01-07       Impact factor: 4.033

5.  Rapid Filament Supramolecular Chirality Reversal of HET-s (218-289) Prion Fibrils Driven by pH Elevation.

Authors:  Maruda Shanmugasundaram; Dmitry Kurouski; William Wan; Gerald Stubbs; Rina K Dukor; Laurence A Nafie; Igor K Lednev
Journal:  J Phys Chem B       Date:  2015-06-26       Impact factor: 2.991

6.  Unsaturation in the Fatty Acids of Phospholipids Drastically Alters the Structure and Toxicity of Insulin Aggregates Grown in Their Presence.

Authors:  Mikhail Matveyenka; Stanislav Rizevsky; Dmitry Kurouski
Journal:  J Phys Chem Lett       Date:  2022-05-17       Impact factor: 6.888

7.  Levels of supramolecular chirality of polyglutamine aggregates revealed by vibrational circular dichroism.

Authors:  Dmitry Kurouski; Karunakar Kar; Ronald Wetzel; Rina K Dukor; Igor K Lednev; Laurence A Nafie
Journal:  FEBS Lett       Date:  2013-04-10       Impact factor: 4.124

8.  Disulfide bridges remain intact while native insulin converts into amyloid fibrils.

Authors:  Dmitry Kurouski; Jacqueline Washington; Mehmet Ozbil; Rajeev Prabhakar; Alexander Shekhtman; Igor K Lednev
Journal:  PLoS One       Date:  2012-06-01       Impact factor: 3.240

9.  pH-Driven Polymorphism of Insulin Amyloid-Like Fibrils.

Authors:  Tomas Sneideris; Domantas Darguzis; Akvile Botyriute; Martynas Grigaliunas; Roland Winter; Vytautas Smirnovas
Journal:  PLoS One       Date:  2015-08-27       Impact factor: 3.240

10.  Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration.

Authors:  Kathleen A Burke; Elizabeth A Yates; Justin Legleiter
Journal:  Front Neurol       Date:  2013-03-01       Impact factor: 4.003
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