OBJECTIVES: A prospective, multicenter (18)fluorine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging study was performed to estimate the correlations among arterial FDG uptake and atherosclerotic plaque biomarkers in patients with peripheral artery disease. BACKGROUND: Inflammation within atherosclerotic plaques is associated with instability of the plaque and future cardiovascular events. Previous studies have shown that (18)F-FDG-PET/CT is able to quantify inflammation within carotid artery atherosclerotic plaques, but no studies to date have investigated this correlation in peripheral arteries with immunohistochemical confirmation. METHODS: Thirty patients across 5 study sites underwent (18)F-FDG-PET/CT imaging before SilverHawk atherectomy (FoxHollow Technologies, Redwood City, California) for symptomatic common or superficial femoral arterial disease. Vascular FDG uptake (expressed as target-to-background ratio) was measured in the carotid arteries and aorta and femoral arteries, including the region of atherectomy. Immunohistochemistry was performed on the excised atherosclerotic plaque extracts, and cluster of differentiation 68 (CD68) level as a measure of macrophage content was determined. Correlations between target-to-background ratio of excised lesions, as well as entire arterial regions, and CD68 levels were determined. Imaging was performed during the 2 weeks before surgery in all cases. RESULTS: Twenty-one patients had adequate-quality (18)F-FDG-PET/CT peripheral artery images, and 34 plaque specimens were obtained. No significant correlation between lesion target-to-background ratio and CD68 level was observed. CONCLUSIONS: There were no significant correlations between CD68 level (as a measure of macrophage content) and FDG uptake in the peripheral arteries in this multicenter study. Differences in lesion extraction technique, lesion size, the degree of inflammation, and imaging coregistration techniques may have been responsible for the failure to observe the strong correlations with vascular FDG uptake observed in previous studies of the carotid artery and in several animal models of atherosclerosis.
OBJECTIVES: A prospective, multicenter (18)fluorine-fluorodeoxyglucose ((18)F-FDG) positron emission tomography (PET)/computed tomography (CT) imaging study was performed to estimate the correlations among arterial FDG uptake and atherosclerotic plaque biomarkers in patients with peripheral artery disease. BACKGROUND:Inflammation within atherosclerotic plaques is associated with instability of the plaque and future cardiovascular events. Previous studies have shown that (18)F-FDG-PET/CT is able to quantify inflammation within carotid artery atherosclerotic plaques, but no studies to date have investigated this correlation in peripheral arteries with immunohistochemical confirmation. METHODS: Thirty patients across 5 study sites underwent (18)F-FDG-PET/CT imaging before SilverHawk atherectomy (FoxHollow Technologies, Redwood City, California) for symptomatic common or superficial femoral arterial disease. Vascular FDG uptake (expressed as target-to-background ratio) was measured in the carotid arteries and aorta and femoral arteries, including the region of atherectomy. Immunohistochemistry was performed on the excised atherosclerotic plaque extracts, and cluster of differentiation 68 (CD68) level as a measure of macrophage content was determined. Correlations between target-to-background ratio of excised lesions, as well as entire arterial regions, and CD68 levels were determined. Imaging was performed during the 2 weeks before surgery in all cases. RESULTS: Twenty-one patients had adequate-quality (18)F-FDG-PET/CT peripheral artery images, and 34 plaque specimens were obtained. No significant correlation between lesion target-to-background ratio and CD68 level was observed. CONCLUSIONS: There were no significant correlations between CD68 level (as a measure of macrophage content) and FDG uptake in the peripheral arteries in this multicenter study. Differences in lesion extraction technique, lesion size, the degree of inflammation, and imaging coregistration techniques may have been responsible for the failure to observe the strong correlations with vascular FDG uptake observed in previous studies of the carotid artery and in several animal models of atherosclerosis.
Authors: John R Davies; James H F Rudd; Tim D Fryer; Martin J Graves; John C Clark; Peter J Kirkpatrick; Jonathan H Gillard; Elizabeth A Warburton; Peter L Weissberg Journal: Stroke Date: 2005-11-10 Impact factor: 7.914
Authors: Ahmed Tawakol; Raymond Q Migrino; Udo Hoffmann; Suhny Abbara; Stuart Houser; Henry Gewirtz; James E Muller; Thomas J Brady; Alan J Fischman Journal: J Nucl Cardiol Date: 2005 May-Jun Impact factor: 5.952
Authors: David Izquierdo-Garcia; John R Davies; Martin J Graves; James H F Rudd; Jonathan H Gillard; Peter L Weissberg; Tim D Fryer; Elizabeth A Warburton Journal: Stroke Date: 2008-10-16 Impact factor: 7.914
Authors: Alan T Hirsch; Ziv J Haskal; Norman R Hertzer; Curtis W Bakal; Mark A Creager; Jonathan L Halperin; Loren F Hiratzka; William R C Murphy; Jeffrey W Olin; Jules B Puschett; Kenneth A Rosenfield; David Sacks; James C Stanley; Lloyd M Taylor; Christopher J White; John White; Rodney A White; Elliott M Antman; Sidney C Smith; Cynthia D Adams; Jeffrey L Anderson; David P Faxon; Valentin Fuster; Raymond J Gibbons; Jonathan L Halperin; Loren F Hiratzka; Sharon A Hunt; Alice K Jacobs; Rick Nishimura; Joseph P Ornato; Richard L Page; Barbara Riegel Journal: J Am Coll Cardiol Date: 2006-03-21 Impact factor: 24.094
Authors: James H F Rudd; Kelly S Myers; Sameer Bansilal; Josef Machac; Mark Woodward; Valentin Fuster; Michael E Farkouh; Zahi A Fayad Journal: Circ Cardiovasc Imaging Date: 2009-01-26 Impact factor: 7.792
Authors: Stephane S Silvera; Hamza El Aidi; James H F Rudd; Venkatesh Mani; Lingde Yang; Michael Farkouh; Valentin Fuster; Zahi A Fayad Journal: Atherosclerosis Date: 2009-04-24 Impact factor: 5.162
Authors: M Angels M Angels Font; Alex Fernandez; Ana Carvajal; Cristina Gamez; Lina Badimon; Mark Slevin; Jerzy Krupinski Journal: Front Biosci (Landmark Ed) Date: 2009-01-01
Authors: Lorenzo Mannelli; Lawrence MacDonald; Marcello Mancini; Marina Ferguson; William P Shuman; Monica Ragucci; Serena Monti; Dongxiang Xu; Chun Yuan; Lee M Mitsumori Journal: Eur Radiol Date: 2014-12-24 Impact factor: 5.315
Authors: Pavlos P Kafouris; Iosif P Koutagiar; Alexandros T Georgakopoulos; Nikoletta K Pianou; Marinos G Metaxas; George M Spyrou; Constantinos D Anagnostopoulos Journal: Int J Cardiovasc Imaging Date: 2019-01-31 Impact factor: 2.357