Masaya Suda1, Tomonari Kiriyama2, Keiichi Ishihara3, Masahisa Onoguchi4, Yasuhiro Kobayashi2, Minoru Sakurai3, Takayuki Shibutani4, Shin-Ichiro Kumita2. 1. Clinical Imaging Center for Healthcare, Nippon Medical School, 1-12-15, Sendagi, Bunkyo, Tokyo, 113-0022, Japan. msuda@nms.ac.jp. 2. Department of Radiology, Nippon Medical School, Tokyo, Japan. 3. Clinical Imaging Center for Healthcare, Nippon Medical School, 1-12-15, Sendagi, Bunkyo, Tokyo, 113-0022, Japan. 4. Department of Quantum Medical Technology, Kanazawa University, Kanazawa, Japan.
Abstract
BACKGROUND: Motion artifact and partial volume effect caused underestimation of coronary plaque inflammation. This study evaluated the high matrix acquisition technique using time-of-flight (TOF) positron emission tomography/computed tomography for imaging of atherosclerotic plaque inflammation with fluorine-18 fluorodeoxyglucose in small and moving phantoms. METHODS AND RESULTS: All images were reconstructed using a conventional algorithm without TOF (4 × 4 × 4 mm3 voxel size) and a high matrix algorithm with TOF (2 × 2 × 2 mm3 voxel size). Microsphere phantoms of 10, 7.9, 6.2, 5.0, and 4.0 mm diameters were acquired in 3-dimensional list-mode for 30 minutes. A heart phantom mimicking cardiac motion consisted of a hot spot simulating a plaque (φ 4 mm, φ 2 mm) on the outside of the left ventricle. In the microsphere and heart phantom study, visual discrimination, maximum activity, and target-to-background ratio using the high matrix algorithm with TOF were better than those using the conventional algorithm without TOF. CONCLUSION: The high matrix algorithm with TOF improves detection of small targets in phantoms.
BACKGROUND: Motion artifact and partial volume effect caused underestimation of coronary plaque inflammation. This study evaluated the high matrix acquisition technique using time-of-flight (TOF) positron emission tomography/computed tomography for imaging of atherosclerotic plaque inflammation with fluorine-18 fluorodeoxyglucose in small and moving phantoms. METHODS AND RESULTS: All images were reconstructed using a conventional algorithm without TOF (4 × 4 × 4 mm3 voxel size) and a high matrix algorithm with TOF (2 × 2 × 2 mm3 voxel size). Microsphere phantoms of 10, 7.9, 6.2, 5.0, and 4.0 mm diameters were acquired in 3-dimensional list-mode for 30 minutes. A heart phantom mimicking cardiac motion consisted of a hot spot simulating a plaque (φ 4 mm, φ 2 mm) on the outside of the left ventricle. In the microsphere and heart phantom study, visual discrimination, maximum activity, and target-to-background ratio using the high matrix algorithm with TOF were better than those using the conventional algorithm without TOF. CONCLUSION: The high matrix algorithm with TOF improves detection of small targets in phantoms.
Authors: Ian S Rogers; Khurram Nasir; Amparo L Figueroa; Ricardo C Cury; Udo Hoffmann; David A Vermylen; Thomas J Brady; Ahmed Tawakol Journal: JACC Cardiovasc Imaging Date: 2010-04
Authors: James H F Rudd; Kelly S Myers; Sameer Bansilal; Josef Machac; Mark Woodward; Valentin Fuster; Michael E Farkouh; Zahi A Fayad Journal: Circ Cardiovasc Imaging Date: 2009-01-26 Impact factor: 7.792
Authors: Zahi A Fayad; Venkatesh Mani; Mark Woodward; David Kallend; Markus Abt; Tracy Burgess; Valentin Fuster; Christie M Ballantyne; Evan A Stein; Jean-Claude Tardif; James H F Rudd; Michael E Farkouh; Ahmed Tawakol Journal: Lancet Date: 2011-09-09 Impact factor: 79.321
Authors: Nikhil V Joshi; Alex T Vesey; Michelle C Williams; Anoop S V Shah; Patrick A Calvert; Felicity H M Craighead; Su Ern Yeoh; William Wallace; Donald Salter; Alison M Fletcher; Edwin J R van Beek; Andrew D Flapan; Neal G Uren; Miles W H Behan; Nicholas L M Cruden; Nicholas L Mills; Keith A A Fox; James H F Rudd; Marc R Dweck; David E Newby Journal: Lancet Date: 2013-11-11 Impact factor: 79.321