Literature DB >> 22211979

Humanized mice as a preclinical tool for infectious disease and biomedical research.

Leonard D Shultz1, Michael A Brehm, Sina Bavari, Dale L Greiner.   

Abstract

Immunodeficient mice bearing an IL2rγ(null) mutation permit engraftment of a functional human immune system and study of human-specific infectious agents that was not previously possible.
© 2011 New York Academy of Sciences.

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Year:  2011        PMID： 22211979      PMCID： PMC3514446          DOI： 10.1111/j.1749-6632.2011.06310.x

Source DB:  PubMed          Journal:  Ann N Y Acad Sci        ISSN： 0077-8923            Impact factor:   5.691


  10 in total

Review 1.  Humanized mice in translational biomedical research.

Authors:  Leonard D Shultz; Fumihiko Ishikawa; Dale L Greiner
Journal:  Nat Rev Immunol       Date:  2007-02       Impact factor: 53.106

2.  Generation of functional human T-cell subsets with HLA-restricted immune responses in HLA class I expressing NOD/SCID/IL2r gamma(null) humanized mice.

Authors:  Leonard D Shultz; Yoriko Saito; Yuho Najima; Satoshi Tanaka; Toshiki Ochi; Mariko Tomizawa; Takehiko Doi; Akiko Sone; Nahoko Suzuki; Hiroshi Fujiwara; Masaki Yasukawa; Fumihiko Ishikawa
Journal:  Proc Natl Acad Sci U S A       Date:  2010-07-06       Impact factor: 11.205

3.  Transgenic expression of human signal regulatory protein alpha in Rag2-/-gamma(c)-/- mice improves engraftment of human hematopoietic cells in humanized mice.

Authors:  Till Strowig; Anthony Rongvaux; Chozhavendan Rathinam; Hitoshi Takizawa; Chiara Borsotti; William Philbrick; Elizabeth E Eynon; Markus G Manz; Richard A Flavell
Journal:  Proc Natl Acad Sci U S A       Date:  2011-07-25       Impact factor: 11.205

4.  Humanized nonobese diabetic-scid IL2rgammanull mice are susceptible to lethal Salmonella Typhi infection.

Authors:  Stephen J Libby; Michael A Brehm; Dale L Greiner; Leonard D Shultz; Michael McClelland; Kelly D Smith; Brad T Cookson; Joyce E Karlinsey; Traci L Kinkel; Steffen Porwollik; Rocio Canals; Lisa A Cummings; Ferric C Fang
Journal:  Proc Natl Acad Sci U S A       Date:  2010-08-16       Impact factor: 11.205

5.  Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML.

Authors:  Yoriko Saito; Naoyuki Uchida; Satoshi Tanaka; Nahoko Suzuki; Mariko Tomizawa-Murasawa; Akiko Sone; Yuho Najima; Shinsuke Takagi; Yuki Aoki; Atsushi Wake; Shuichi Taniguchi; Leonard D Shultz; Fumihiko Ishikawa
Journal:  Nat Biotechnol       Date:  2010-02-14       Impact factor: 54.908

6.  T cell-specific siRNA delivery suppresses HIV-1 infection in humanized mice.

Authors:  Priti Kumar; Hong-Seok Ban; Sang-Soo Kim; Haoquan Wu; Todd Pearson; Dale L Greiner; Amale Laouar; Jiahong Yao; Viraga Haridas; Katsuyoshi Habiro; Yong-Guang Yang; Ji-Hoon Jeong; Kuen-Yong Lee; Yong-Hee Kim; Sung Wan Kim; Matthias Peipp; Georg H Fey; N Manjunath; Leonard D Shultz; Sang-Kyung Lee; Premlata Shankar
Journal:  Cell       Date:  2008-08-07       Impact factor: 41.582

7.  Parameters for establishing humanized mouse models to study human immunity: analysis of human hematopoietic stem cell engraftment in three immunodeficient strains of mice bearing the IL2rgamma(null) mutation.

Authors:  Michael A Brehm; Amy Cuthbert; Chaoxing Yang; David M Miller; Philip DiIorio; Joseph Laning; Lisa Burzenski; Bruce Gott; Oded Foreman; Anoop Kavirayani; Mary Herlihy; Aldo A Rossini; Leonard D Shultz; Dale L Greiner
Journal:  Clin Immunol       Date:  2010-01-21       Impact factor: 3.969

8.  Sepsis-induced human lymphocyte apoptosis and cytokine production in "humanized" mice.

Authors:  Jacqueline Unsinger; Jacquelyn S McDonough; Leonard D Shultz; Thomas A Ferguson; Richard S Hotchkiss
Journal:  J Leukoc Biol       Date:  2009-04-15       Impact factor: 4.962

9.  Dengue virus infection and virus-specific HLA-A2 restricted immune responses in humanized NOD-scid IL2rgammanull mice.

Authors:  Smita Jaiswal; Todd Pearson; Heather Friberg; Leonard D Shultz; Dale L Greiner; Alan L Rothman; Anuja Mathew
Journal:  PLoS One       Date:  2009-10-05       Impact factor: 3.240

10.  Human peripheral blood leucocyte non-obese diabetic-severe combined immunodeficiency interleukin-2 receptor gamma chain gene mouse model of xenogeneic graft-versus-host-like disease and the role of host major histocompatibility complex.

Authors:  M A King; L Covassin; M A Brehm; W Racki; T Pearson; J Leif; J Laning; W Fodor; O Foreman; L Burzenski; T H Chase; B Gott; A A Rossini; R Bortell; L D Shultz; D L Greiner
Journal:  Clin Exp Immunol       Date:  2009-07       Impact factor: 4.330
  10 in total
  34 in total

1.  Ebola virus disease in mice with transplanted human hematopoietic stem cells.

Authors:  Anja Lüdtke; Lisa Oestereich; Paula Ruibal; Stephanie Wurr; Elisa Pallasch; Sabrina Bockholt; Wing Hang Ip; Toni Rieger; Sergio Gómez-Medina; Carol Stocking; Estefanía Rodríguez; Stephan Günther; César Muñoz-Fontela
Journal:  J Virol       Date:  2015-02-11       Impact factor: 5.103

Review 2.  Use of Humanized Mice to Study the Pathogenesis of Autoimmune and Inflammatory Diseases.

Authors:  Iurii Koboziev; Yava Jones-Hall; John F Valentine; Cynthia Reinoso Webb; Kathryn L Furr; Matthew B Grisham
Journal:  Inflamm Bowel Dis       Date:  2015-07       Impact factor: 5.325

Review 3.  New generation humanized mice for virus research: comparative aspects and future prospects.

Authors:  Ramesh Akkina
Journal:  Virology       Date:  2013-01-05       Impact factor: 3.616

Review 4.  Understanding Normal and Malignant Human Hematopoiesis Using Next-Generation Humanized Mice.

Authors:  Yoriko Saito; Leonard D Shultz; Fumihiko Ishikawa
Journal:  Trends Immunol       Date:  2020-07-03       Impact factor: 16.687

Review 5.  Humanized mice for immune system investigation: progress, promise and challenges.

Authors:  Leonard D Shultz; Michael A Brehm; J Victor Garcia-Martinez; Dale L Greiner
Journal:  Nat Rev Immunol       Date:  2012-10-12       Impact factor: 53.106

6.  IL-21 accelerates xenogeneic graft-versus-host disease correlated with increased B-cell proliferation.

Authors:  Xiaoran Wu; Yi Tan; Qiao Xing; Shengdian Wang
Journal:  Protein Cell       Date:  2013-11-10       Impact factor: 14.870

Review 7.  Bioreactor engineering of stem cell environments.

Authors:  Nina Tandon; Darja Marolt; Elisa Cimetta; Gordana Vunjak-Novakovic
Journal:  Biotechnol Adv       Date:  2013-03-24       Impact factor: 14.227

8.  The Presence and Preferential Activation of Regulatory T Cells Diminish Adoptive Transfer of Autoimmune Diabetes by Polyclonal Nonobese Diabetic (NOD) T Cell Effectors into NSG versus NOD-scid Mice.

Authors:  Maximiliano Presa; Yi-Guang Chen; Alexandra E Grier; Edward H Leiter; Michael A Brehm; Dale L Greiner; Leonard D Shultz; David V Serreze
Journal:  J Immunol       Date:  2015-08-17       Impact factor: 5.422

9.  In vivo blockade of the PD-1 receptor suppresses HIV-1 viral loads and improves CD4+ T cell levels in humanized mice.

Authors:  Brent E Palmer; C Preston Neff; Jonathan Lecureux; Angelica Ehler; Michelle Dsouza; Leila Remling-Mulder; Alan J Korman; Andrew P Fontenot; Ramesh Akkina
Journal:  J Immunol       Date:  2012-12-03       Impact factor: 5.422

10.  Human immune system development and survival of non-obese diabetic (NOD)-scid IL2rγ(null) (NSG) mice engrafted with human thymus and autologous haematopoietic stem cells.

Authors:  L Covassin; S Jangalwe; N Jouvet; J Laning; L Burzenski; L D Shultz; M A Brehm
Journal:  Clin Exp Immunol       Date:  2013-12       Impact factor: 4.330
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