Literature DB >> 17259968

Humanized mice in translational biomedical research.

Leonard D Shultz1, Fumihiko Ishikawa, Dale L Greiner.   

Abstract

The culmination of decades of research on humanized mice is leading to advances in our understanding of human haematopoiesis, innate and adaptive immunity, autoimmunity, infectious diseases, cancer biology and regenerative medicine. In this Review, we discuss the development of these new generations of humanized mice, how they will facilitate translational research in several biomedical disciplines and approaches to overcome the remaining limitations of these models.

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Year:  2007        PMID： 17259968     DOI： 10.1038/nri2017

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  586 in total

1.  Characteristics of Borrelia hermsii infection in human hematopoietic stem cell-engrafted mice mirror those of human relapsing fever.

Authors:  Raja Vuyyuru; Hongqi Liu; Tim Manser; Kishore R Alugupalli
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-05       Impact factor: 11.205

2.  Humanized mice for the study of type 1 and type 2 diabetes.

Authors:  Dale L Greiner; Michael A Brehm; Vishnu Hosur; David M Harlan; Alvin C Powers; Leonard D Shultz
Journal:  Ann N Y Acad Sci       Date:  2011-12       Impact factor: 5.691

3.  Autoimmunity's next top models.

Authors:  Hartmut Wekerle; Alexander Flügel; Lars Fugger; Georg Schett; David Serreze
Journal:  Nat Med       Date:  2012-01-06       Impact factor: 53.440

4.  Tobacco smoke-induced immunologic changes may contribute to oral carcinogenesis.

Authors:  Michael Schierl; Daxesh Patel; Wanhong Ding; Amit Kochhar; Katayun Adhami; Xi Kathy Zhou; Andrew J Dannenberg; Richard D Granstein
Journal:  J Investig Med       Date:  2014-02       Impact factor: 2.895

5.  Nanofiber-expanded human umbilical cord blood-derived CD34+ cell therapy accelerates murine cutaneous wound closure by attenuating pro-inflammatory factors and secreting IL-10.

Authors:  Suman Kanji; Manjusri Das; Reeva Aggarwal; Jingwei Lu; Matthew Joseph; Sujit Basu; Vincent J Pompili; Hiranmoy Das
Journal:  Stem Cell Res       Date:  2013-11-15       Impact factor: 2.020

6.  Establishment of an immunodeficient alcohol mouse model to study the effects of alcohol on human cells in vivo.

Authors:  John Powers; Hui Zhang; Logan Battrell; Gary G Meadows; Grant D Trobridge
Journal:  J Stud Alcohol Drugs       Date:  2012-11       Impact factor: 2.582

7.  OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.

Authors:  Mark Wunderlich; Ryan A Brooks; Rushi Panchal; Garrett W Rhyasen; Gwenn Danet-Desnoyers; James C Mulloy
Journal:  Blood       Date:  2014-04-28       Impact factor: 22.113

8.  IL-21 accelerates xenogeneic graft-versus-host disease correlated with increased B-cell proliferation.

Authors:  Xiaoran Wu; Yi Tan; Qiao Xing; Shengdian Wang
Journal:  Protein Cell       Date:  2013-11-10       Impact factor: 14.870

Review 9.  Mouse models in bone marrow transplantation and adoptive cellular therapy.

Authors:  Caroline Arber; Malcolm K Brenner; Pavan Reddy
Journal:  Semin Hematol       Date:  2013-06-11       Impact factor: 3.851

10.  Efficiency and safety of O⁶-methylguanine DNA methyltransferase (MGMT(P140K))-mediated in vivo selection in a humanized mouse model.

Authors:  Ruhi Phaltane; Reinhard Haemmerle; Michael Rothe; Ute Modlich; Thomas Moritz
Journal:  Hum Gene Ther       Date:  2014-01-07       Impact factor: 5.695
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