Literature DB >> 23059428

Humanized mice for immune system investigation: progress, promise and challenges.

Leonard D Shultz1, Michael A Brehm, J Victor Garcia-Martinez, Dale L Greiner.   

Abstract

Significant advances in our understanding of the in vivo functions of human cells and tissues and the human immune system have resulted from the development of 'humanized' mouse strains that are based on severely immunodeficient mice with mutations in the interleukin-2 receptor common γ-chain locus. These mouse strains support the engraftment of a functional human immune system and permit detailed analyses of human immune biology, development and functions. In this Review, we discuss recent advances in the development and utilization of humanized mice, the lessons learnt, the remaining challenges and the promise of using humanized mice for the in vivo study of human immunology.

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Year:  2012        PMID： 23059428      PMCID： PMC3749872          DOI： 10.1038/nri3311

Source DB:  PubMed          Journal:  Nat Rev Immunol        ISSN： 1474-1733            Impact factor:   53.106


  124 in total

1.  Induction of human humoral immune responses in a novel HLA-DR-expressing transgenic NOD/Shi-scid/γcnull mouse.

Authors:  Makiko Suzuki; Takeshi Takahashi; Ikumi Katano; Ryoji Ito; Mamoru Ito; Hideo Harigae; Naoto Ishii; Kazuo Sugamura
Journal:  Int Immunol       Date:  2012-03-07       Impact factor: 4.823

2.  Membrane-bound human SCF/KL promotes in vivo human hematopoietic engraftment and myeloid differentiation.

Authors:  Shinsuke Takagi; Yoriko Saito; Atsushi Hijikata; Satoshi Tanaka; Takashi Watanabe; Takanori Hasegawa; Shinobu Mochizuki; Jun Kunisawa; Hiroshi Kiyono; Haruhiko Koseki; Osamu Ohara; Takashi Saito; Shuichi Taniguchi; Leonard D Shultz; Fumihiko Ishikawa
Journal:  Blood       Date:  2012-01-25       Impact factor: 22.113

Review 3.  Engineering humanized mice for improved hematopoietic reconstitution.

Authors:  Adam C Drake; Qingfeng Chen; Jianzhu Chen
Journal:  Cell Mol Immunol       Date:  2012-03-19       Impact factor: 11.530

4.  Enhanced humoral and HLA-A2-restricted dengue virus-specific T-cell responses in humanized BLT NSG mice.

Authors:  Smita Jaiswal; Pamela Pazoles; Marcia Woda; Leonard D Shultz; Dale L Greiner; Michael A Brehm; Anuja Mathew
Journal:  Immunology       Date:  2012-07       Impact factor: 7.397

5.  Engraftment of human HSCs in nonirradiated newborn NOD-scid IL2rγ null mice is enhanced by transgenic expression of membrane-bound human SCF.

Authors:  Michael A Brehm; Waldemar J Racki; Jean Leif; Lisa Burzenski; Vishnu Hosur; Amber Wetmore; Bruce Gott; Mary Herlihy; Ronald Ignotz; Raymond Dunn; Leonard D Shultz; Dale L Greiner
Journal:  Blood       Date:  2012-01-12       Impact factor: 22.113

6.  Humanized tumor mice--a new model to study and manipulate the immune response in advanced cancer therapy.

Authors:  Anja K Wege; Wolfgang Ernst; Judith Eckl; Bernhard Frankenberger; Arabel Vollmann-Zwerenz; Daniela N Männel; Olaf Ortmann; Alexander Kroemer; Gero Brockhoff
Journal:  Int J Cancer       Date:  2011-07-21       Impact factor: 7.396

7.  Rapid generation of human B-cell lymphomas via combined expression of Myc and Bcl2 and their use as a preclinical model for biological therapies.

Authors:  Ilya Leskov; Christian P Pallasch; Adam Drake; Bettina P Iliopoulou; Amanda Souza; Ching-Hung Shen; Carmen D Schweighofer; Lynne Abruzzo; Lukas P Frenzel; Clemens M Wendtner; Michael T Hemann; Jianzhu Chen
Journal:  Oncogene       Date:  2012-04-09       Impact factor: 9.867

8.  Inhibition of in vivo HIV infection in humanized mice by gene therapy of human hematopoietic stem cells with a lentiviral vector encoding a broadly neutralizing anti-HIV antibody.

Authors:  Aviva Joseph; Jian Hua Zheng; Ken Chen; Monica Dutta; Cindy Chen; Gabriela Stiegler; Renate Kunert; Antonia Follenzi; Harris Goldstein
Journal:  J Virol       Date:  2010-04-21       Impact factor: 5.103

9.  In vivo prevention of transplant arteriosclerosis by ex vivo-expanded human regulatory T cells.

Authors:  Satish N Nadig; Joanna Wieckiewicz; Douglas C Wu; Gregor Warnecke; Wei Zhang; Shiqiao Luo; Alexandru Schiopu; David P Taggart; Kathryn J Wood
Journal:  Nat Med       Date:  2010-05-16       Impact factor: 53.440

10.  Latent HIV-1 infection of resting CD4⁺ T cells in the humanized Rag2⁻/⁻ γc⁻/⁻ mouse.

Authors:  Shailesh K Choudhary; Nancie M Archin; Manzoor Cheema; Noelle P Dahl; J Victor Garcia; David M Margolis
Journal:  J Virol       Date:  2011-10-19       Impact factor: 5.103
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  389 in total

Review 1.  Humanized Mice in Dermatology Research.

Authors:  Russell L Griffin; Thomas S Kupper; Sherrie J Divito
Journal:  J Invest Dermatol       Date:  2015-12       Impact factor: 8.551

2.  Transgenic animals and genetic engineering techniques. Nantes, France, 2-3 July, 2015.

Authors:  Séverine Ménoret; Laurent Tesson; Séverine Remy; Claire Usal; Laure-Hélène Ouisse; Lucas Brusselle; Vanessa Chenouard; Tuan H Nguyen; Laurent David; Ignacio Anegon
Journal:  Transgenic Res       Date:  2015-09-10       Impact factor: 2.788

Review 3.  Experimental approaches for defining functional roles of microbes in the human gut.

Authors:  Gautam Dantas; Morten O A Sommer; Patrick H Degnan; Andrew L Goodman
Journal:  Annu Rev Microbiol       Date:  2013       Impact factor: 15.500

4.  Zika viral infection and neutralizing human antibody response in a BLT humanized mouse model.

Authors:  Kimberly Schmitt; Paige Charlins; Milena Veselinovic; Lauren Kinner-Bibeau; Shuang Hu; James Curlin; Leila Remling-Mulder; Ken E Olson; Tawfik Aboellail; Ramesh Akkina
Journal:  Virology       Date:  2018-01-06       Impact factor: 3.616

5.  Fatal autoimmunity in mice reconstituted with human hematopoietic stem cells encoding defective FOXP3.

Authors:  Jeremy A Goettel; Subhabrata Biswas; Willem S Lexmond; Ada Yeste; Laura Passerini; Bonny Patel; Siyoung Yang; Jiusong Sun; Jodie Ouahed; Dror S Shouval; Katelyn J McCann; Bruce H Horwitz; Diane Mathis; Edgar L Milford; Luigi D Notarangelo; Maria-Grazia Roncarolo; Edda Fiebiger; Wayne A Marasco; Rosa Bacchetta; Francisco J Quintana; Sung-Yun Pai; Christoph Klein; Aleixo M Muise; Scott B Snapper
Journal:  Blood       Date:  2015-04-01       Impact factor: 22.113

6.  OKT3 prevents xenogeneic GVHD and allows reliable xenograft initiation from unfractionated human hematopoietic tissues.

Authors:  Mark Wunderlich; Ryan A Brooks; Rushi Panchal; Garrett W Rhyasen; Gwenn Danet-Desnoyers; James C Mulloy
Journal:  Blood       Date:  2014-04-28       Impact factor: 22.113

7.  LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis.

Authors:  Shi-Dong Ma; Xuequn Xu; Julie Plowshay; Erik A Ranheim; William J Burlingham; Jeffrey L Jensen; Fotis Asimakopoulos; Weihua Tang; Margaret L Gulley; Ethel Cesarman; Jenny E Gumperz; Shannon C Kenney
Journal:  J Clin Invest       Date:  2014-12-08       Impact factor: 14.808

8.  TLR3 agonist and CD40-targeting vaccination induces immune responses and reduces HIV-1 reservoirs.

Authors:  Liang Cheng; Qi Wang; Guangming Li; Riddhima Banga; Jianping Ma; Haisheng Yu; Fumihiko Yasui; Zheng Zhang; Giuseppe Pantaleo; Matthieu Perreau; Sandra Zurawski; Gerard Zurawski; Yves Levy; Lishan Su
Journal:  J Clin Invest       Date:  2018-08-27       Impact factor: 14.808

Review 9.  Choosing The Right Animal Model for Renal Cancer Research.

Authors:  Paweł Sobczuk; Anna Brodziak; Mohammed Imran Khan; Stuti Chhabra; Michał Fiedorowicz; Marlena Wełniak-Kamińska; Kamil Synoradzki; Ewa Bartnik; Agnieszka Cudnoch-Jędrzejewska; Anna M Czarnecka
Journal:  Transl Oncol       Date:  2020-02-22       Impact factor: 4.243

10.  Blocking type I interferon signaling enhances T cell recovery and reduces HIV-1 reservoirs.

Authors:  Liang Cheng; Jianping Ma; Jingyun Li; Dan Li; Guangming Li; Feng Li; Qing Zhang; Haisheng Yu; Fumihiko Yasui; Chaobaihui Ye; Li-Chung Tsao; Zhiyuan Hu; Lishan Su; Liguo Zhang
Journal:  J Clin Invest       Date:  2016-12-12       Impact factor: 14.808
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