Literature DB >> 25673711

Ebola virus disease in mice with transplanted human hematopoietic stem cells.

Anja Lüdtke1, Lisa Oestereich2, Paula Ruibal1, Stephanie Wurr2, Elisa Pallasch2, Sabrina Bockholt2, Wing Hang Ip3, Toni Rieger2, Sergio Gómez-Medina3, Carol Stocking3, Estefanía Rodríguez3, Stephan Günther2, César Muñoz-Fontela4.   

Abstract

The development of treatments for Ebola virus disease (EVD) has been hampered by the lack of small-animal models that mimick human disease. Here we show that mice with transplanted human hematopoetic stem cells reproduce features typical of EVD. Infection with Ebola virus was associated with viremia, cell damage, liver steatosis, signs of hemorrhage, and high lethality. Our study provides a small-animal model with human components for the development of EVD therapies.
Copyright © 2015, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 25673711      PMCID： PMC4442348          DOI： 10.1128/JVI.03546-14

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


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