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Literature DB >> 22154944

Structural organization of the kinetochore-microtubule interface.

Abstract

Successful mitosis depends on the stable, yet regulated attachment of chromosomes to spindle microtubules. The kinetochore, a large macromolecular structure assembled at sites of centromeric heterochromatin, is responsible for generating and regulating these essential attachments. Over the last several years, concerted experimental efforts have brought the structural view of the kinetochore-microtubule interface more clearly into focus. Here, we review important recent advancements and discuss several unresolved questions regarding how kinetochores dynamically bridge mitotic chromosomes to spindle microtubules.

Entities: CellLine Chemical Disease Gene Mutation Species

Mesh：

Year: 2011 PMID： 22154944 PMCID： PMC3294040 DOI： 10.1016/j.ceb.2011.11.003

Source DB: PubMed Journal: Curr Opin Cell Biol ISSN： 0955-0674 Impact factor: 8.382

73 in total

1. A blueprint for kinetochores - new insights into the molecular mechanics of cell division.

Authors: Fabienne Lampert; Stefan Westermann
Journal: Nat Rev Mol Cell Biol Date: 2011-06-02 Impact factor: 94.444

2. Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes.

Authors: Tomoya S Kitajima; Miho Ohsugi; Jan Ellenberg
Journal: Cell Date: 2011-08-19 Impact factor: 41.582

3. The spatial arrangement of chromosomes during prometaphase facilitates spindle assembly.

Authors: Valentin Magidson; Christopher B O'Connell; Jadranka Lončarek; Raja Paul; Alex Mogilner; Alexey Khodjakov
Journal: Cell Date: 2011-08-19 Impact factor: 41.582

4. Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes.

Authors: Karen E Gascoigne; Kozo Takeuchi; Aussie Suzuki; Tetsuya Hori; Tatsuo Fukagawa; Iain M Cheeseman
Journal: Cell Date: 2011-04-29 Impact factor: 41.582

Review 5. Structures and functions of yeast kinetochore complexes.

Authors: Stefan Westermann; David G Drubin; Georjana Barnes
Journal: Annu Rev Biochem Date: 2007 Impact factor: 23.643

Review 6. Visualizing kinetochore architecture.

Authors: Gregory Alushin; Eva Nogales
Journal: Curr Opin Struct Biol Date: 2011-08-22 Impact factor: 6.809

7. The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.

Authors: John G Tooley; Stephanie A Miller; P Todd Stukenberg
Journal: Mol Biol Cell Date: 2011-02-16 Impact factor: 4.138

8. Insights into EB1 structure and the role of its C-terminal domain for discriminating microtubule tips from the lattice.

Authors: Rubén M Buey; Renu Mohan; Kris Leslie; Thomas Walzthoeni; John H Missimer; Andreas Menzel; Saša Bjelic; Katja Bargsten; Ilya Grigoriev; Ihor Smal; Erik Meijering; Ruedi Aebersold; Anna Akhmanova; Michel O Steinmetz
Journal: Mol Biol Cell Date: 2011-07-07 Impact factor: 4.138

9. In vitro centromere and kinetochore assembly on defined chromatin templates.

Authors: Annika Guse; Christopher W Carroll; Ben Moree; Colin J Fuller; Aaron F Straight
Journal: Nature Date: 2011-08-28 Impact factor: 49.962

10. Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.

Authors: Randy Wei; Bryan Ngo; Guikai Wu; Wen-Hwa Lee
Journal: Mol Biol Cell Date: 2011-08-10 Impact factor: 4.138

56 in total

1. Deformations within moving kinetochores reveal different sites of active and passive force generation.

Authors: Sophie Dumont; E D Salmon; Timothy J Mitchison
Journal: Science Date: 2012-06-21 Impact factor: 47.728

Review 2. How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.

Authors: Shivangi Agarwal; Dileep Varma
Journal: Bioarchitecture Date: 2015-10-02

Review 3. The kinetochore.

Authors: Iain M Cheeseman
Journal: Cold Spring Harb Perspect Biol Date: 2014-07-01 Impact factor: 10.005

Structural organization of the kinetochore-microtubule interface.

1. A blueprint for kinetochores - new insights into the molecular mechanics of cell division.

2. Complete kinetochore tracking reveals error-prone homologous chromosome biorientation in mammalian oocytes.

3. The spatial arrangement of chromosomes during prometaphase facilitates spindle assembly.

4. Induced ectopic kinetochore assembly bypasses the requirement for CENP-A nucleosomes.

Review 5. Structures and functions of yeast kinetochore complexes.

Review 6. Visualizing kinetochore architecture.

7. The Ndc80 complex uses a tripartite attachment point to couple microtubule depolymerization to chromosome movement.

8. Insights into EB1 structure and the role of its C-terminal domain for discriminating microtubule tips from the lattice.

9. In vitro centromere and kinetochore assembly on defined chromatin templates.

10. Phosphorylation of the Ndc80 complex protein, HEC1, by Nek2 kinase modulates chromosome alignment and signaling of the spindle assembly checkpoint.

1. Deformations within moving kinetochores reveal different sites of active and passive force generation.

Review 2. How the SAC gets the axe: Integrating kinetochore microtubule attachments with spindle assembly checkpoint signaling.

Review 3. The kinetochore.

4. Phenotypic characterization of diamond (dind), a Drosophila gene required for multiple aspects of cell division.

5. CENP-T provides a structural platform for outer kinetochore assembly.

Review 6. Maturation of the kinetochore-microtubule interface and the meaning of metaphase.

Review 7. The KMN protein network--chief conductors of the kinetochore orchestra.

8. Phosphoregulation promotes release of kinetochores from dynamic microtubules via multiple mechanisms.

9. A mathematical model of force generation by flexible kinetochore-microtubule attachments.

Review 10. Linked in: formation and regulation of microtubule attachments during chromosome segregation.