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Literature DB >> 21633384

A blueprint for kinetochores - new insights into the molecular mechanics of cell division.

Abstract

Kinetochores are large proteinaceous complexes that physically link centromeric DNA to the plus ends of spindle microtubules. Stable kinetochore-microtubule attachments are a prerequisite for the accurate and efficient distribution of genetic material over multiple generations. In the past decade, concerted research has resulted in the identification of the individual kinetochore building blocks, the characterization of critical microtubule-interacting components, such as the NDC80 complex, and the development of an approximate model of the architecture of this sophisticated biological machine.

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Year: 2011 PMID： 21633384 DOI： 10.1038/nrm3133

Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444

51 in total

1. Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.

Authors: Claudio Ciferri; Sebastiano Pasqualato; Emanuela Screpanti; Gianluca Varetti; Stefano Santaguida; Gabriel Dos Reis; Alessio Maiolica; Jessica Polka; Jennifer G De Luca; Peter De Wulf; Mogjiborahman Salek; Juri Rappsilber; Carolyn A Moores; Edward D Salmon; Andrea Musacchio
Journal: Cell Date: 2008-05-02 Impact factor: 41.582

2. Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation.

Authors: Carsten Janke; Jennifer Ortíz; Tomoyuki U Tanaka; Johannes Lechner; Elmar Schiebel
Journal: EMBO J Date: 2002-01-15 Impact factor: 11.598

3. The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex.

Authors: Fabienne Lampert; Peter Hornung; Stefan Westermann
Journal: J Cell Biol Date: 2010-05-17 Impact factor: 10.539

4. Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes.

Authors: Tomomi Kiyomitsu; Osamu Iwasaki; Chikashi Obuse; Mitsuhiro Yanagida
Journal: J Cell Biol Date: 2010-03-15 Impact factor: 10.539

5. A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast.

Authors: Eva Kiermaier; Sophie Woehrer; Yutian Peng; Karl Mechtler; Stefan Westermann
Journal: Nat Cell Biol Date: 2009-08-16 Impact factor: 28.824

6. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates.

Authors: Dan Liu; Gerben Vader; Martijn J M Vromans; Michael A Lampson; Susanne M A Lens
Journal: Science Date: 2009-01-15 Impact factor: 47.728

7. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans.

Authors: Arshad Desai; Sonja Rybina; Thomas Müller-Reichert; Andrej Shevchenko; Anna Shevchenko; Anthony Hyman; Karen Oegema
Journal: Genes Dev Date: 2003-10-01 Impact factor: 11.361

8. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.

Authors: Emanuela Screpanti; Anna De Antoni; Gregory M Alushin; Arsen Petrovic; Tiziana Melis; Eva Nogales; Andrea Musacchio
Journal: Curr Biol Date: 2011-02-25 Impact factor: 10.834

9. Mitotic spindle integrity and kinetochore function linked by the Duo1p/Dam1p complex.

Authors: I M Cheeseman; M Enquist-Newman; T Müller-Reichert; D G Drubin; G Barnes
Journal: J Cell Biol Date: 2001-01-08 Impact factor: 10.539

10. Architecture and flexibility of the yeast Ndc80 kinetochore complex.

Authors: Hong-Wei Wang; Sydney Long; Claudio Ciferri; Stefan Westermann; David Drubin; Georjana Barnes; Eva Nogales
Journal: J Mol Biol Date: 2008-09-05 Impact factor: 5.469

35 in total

1. Cell division: CENPA's tail rules the centromere.

Authors: Joanna E Huddleston
Journal: Nat Rev Mol Cell Biol Date: 2011-09-23 Impact factor: 94.444

2. A missense variant in NUF2, a component of the kinetochore NDC80 complex, causes impaired chromosome segregation and aneuploidy associated with microcephaly and short stature.

Authors: Daniela Tiaki Uehara; Hiroshi Mitsubuchi; Johji Inazawa
Journal: Hum Genet Date: 2021-03-15 Impact factor: 4.132

A blueprint for kinetochores - new insights into the molecular mechanics of cell division.

1. Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex.

2. Four new subunits of the Dam1-Duo1 complex reveal novel functions in sister kinetochore biorientation.

3. The Dam1 complex confers microtubule plus end-tracking activity to the Ndc80 kinetochore complex.

4. Inner centromere formation requires hMis14, a trident kinetochore protein that specifically recruits HP1 to human chromosomes.

5. A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast.

6. Sensing chromosome bi-orientation by spatial separation of aurora B kinase from kinetochore substrates.

7. KNL-1 directs assembly of the microtubule-binding interface of the kinetochore in C. elegans.

8. Direct binding of Cenp-C to the Mis12 complex joins the inner and outer kinetochore.

9. Mitotic spindle integrity and kinetochore function linked by the Duo1p/Dam1p complex.

10. Architecture and flexibility of the yeast Ndc80 kinetochore complex.

1. Cell division: CENPA's tail rules the centromere.

2. A missense variant in NUF2, a component of the kinetochore NDC80 complex, causes impaired chromosome segregation and aneuploidy associated with microcephaly and short stature.

Review 3. Reconstituting the kinetochore–microtubule interface: what, why, and how.

4. T time for point centromeres.

5. CENP-T proteins are conserved centromere receptors of the Ndc80 complex.

Review 6. Geometry and force behind kinetochore orientation: lessons from meiosis.

Review 7. Mitotic spindle assembly in animal cells: a fine balancing act.

8. A structural basis for kinetochore recruitment of the Ndc80 complex via two distinct centromere receptors.

9. The spindle assembly checkpoint: More than just keeping track of the spindle.

Review 10. Functions of the centromere and kinetochore in chromosome segregation.