OBJECTIVES: To examine the relationship of serum 25-hydroxy vitamin D3 with cognitive functioning in higher age, using an instrument covering multiple cognitive domains in a population-based study. DESIGN: Follow-up study with measurement of vitamin D levels at baseline and assessment of cognitive functioning at year 5 follow-up. SETTING AND PARTICIPANTS: A subgroup of 1639 participants of the ongoing epidemiological ESTHER study of the elderly general population in Saarland State, Germany, aged 65+ years at baseline (2000-2002). INTERVENTION: Observational study. MEASUREMENTS: Cognitive functioning was assessed by the COGTEL phone interview developed by Kliegel et al., which was administered 5 years after ESTHER baseline. Vitamin D in baseline samples was measured by chemiluminescence methods. Additional information was obtained by standardised questionnaires. RESULTS: In multiple linear regression adjusted for important confounders, women in the lowest sex-specific quintile of vitamin D showed an on average 2.1 (95% confidence interval: 0.4 to 3.9) units lower COGTEL score than women in the highest quintile. A similar, albeit slightly weaker, association was seen in males (difference of 1.7 [-0.4 to 3.8] units). Spline regression suggested non-linearity with a distinct decline in cognitive performance in the lower range of vitamin D levels. CONCLUSIONS: Our findings support suggestions that low levels of vitamin D may be associated with reduced cognitive functioning in the elderly.
OBJECTIVES: To examine the relationship of serum 25-hydroxy vitamin D3 with cognitive functioning in higher age, using an instrument covering multiple cognitive domains in a population-based study. DESIGN: Follow-up study with measurement of vitamin D levels at baseline and assessment of cognitive functioning at year 5 follow-up. SETTING AND PARTICIPANTS: A subgroup of 1639 participants of the ongoing epidemiological ESTHER study of the elderly general population in Saarland State, Germany, aged 65+ years at baseline (2000-2002). INTERVENTION: Observational study. MEASUREMENTS: Cognitive functioning was assessed by the COGTEL phone interview developed by Kliegel et al., which was administered 5 years after ESTHER baseline. Vitamin D in baseline samples was measured by chemiluminescence methods. Additional information was obtained by standardised questionnaires. RESULTS: In multiple linear regression adjusted for important confounders, women in the lowest sex-specific quintile of vitamin D showed an on average 2.1 (95% confidence interval: 0.4 to 3.9) units lower COGTEL score than women in the highest quintile. A similar, albeit slightly weaker, association was seen in males (difference of 1.7 [-0.4 to 3.8] units). Spline regression suggested non-linearity with a distinct decline in cognitive performance in the lower range of vitamin D levels. CONCLUSIONS: Our findings support suggestions that low levels of vitamin D may be associated with reduced cognitive functioning in the elderly.
Authors: May A Beydoun; Sharmin Hossain; Marie T Fanelli-Kuczmarski; Hind A Beydoun; Jose-Atilio Canas; Michele K Evans; Alan B Zonderman Journal: J Clin Endocrinol Metab Date: 2018-04-01 Impact factor: 5.958
Authors: Valerie K Wilson; Denise K Houston; Laurel Kilpatrick; James Lovato; Kristine Yaffe; Jane A Cauley; Tamara B Harris; Eleanor M Simonsick; Hilsa N Ayonayon; Stephen B Kritchevsky; Kaycee M Sink Journal: J Am Geriatr Soc Date: 2014-03-17 Impact factor: 5.562
Authors: A L C Schneider; P L Lutsey; A Alonso; R F Gottesman; A R Sharrett; K A Carson; M Gross; W S Post; D S Knopman; T H Mosley; E D Michos Journal: Eur J Neurol Date: 2014-05-21 Impact factor: 6.089
Authors: E G H M van den Heuvel; N M van Schoor; C Vermeer; R M L Zwijsen; M den Heijer; H C Comijs Journal: J Nutr Health Aging Date: 2015-11 Impact factor: 4.075
Authors: David B Matchar; Choy-Lye Chei; Zhao-Xue Yin; Victoria Koh; Bibhas Chakraborty; Xiao-Ming Shi; Yi Zeng Journal: J Gerontol A Biol Sci Med Sci Date: 2016-07-12 Impact factor: 6.053
Authors: Alexandra M Kueider; Toshiko Tanaka; Yang An; Melissa H Kitner-Triolo; Elango Palchamy; Luigi Ferrucci; Madhav Thambisetty Journal: Neurobiol Aging Date: 2015-11-18 Impact factor: 4.673
Authors: Caroline S Duchaine; Denis Talbot; Mohamed Nafti; Yves Giguère; Sylvie Dodin; André Tourigny; Pierre-Hugues Carmichael; Danielle Laurin Journal: Can J Public Health Date: 2020-02-03