OBJECTIVES: The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D. DESIGN: Longitudinal study with six years follow-up. SETTING: Community based. PARTICIPANTS: 599 participants of the Longitudinal Aging Study Amsterdam (aged 55-65 years). MEASUREMENTS: Information processing speed and a composite Z-score by combining three domains of cognition reflecting general cognitive functioning. RESULTS: Generalized estimating equations (GEE) showed no significant associations between dp-ucMGP and decline in general cognitive functioning. Vitamin D modified the association between dp-ucMGP and speed of information processing (p<0.05). In the group with a 25(OH)D concentration > 50 nmol/l, the highest tertile of dp-ucMGP (>406 pmol/l), which corresponds to lower vitamin K levels, was associated with 1.5 higher score on information processing speed (p=0.023) as compared to the lowest tertile of dp-ucMGP. CONCLUSION: In contrast to our hypothesis, a suboptimal vitamin K was not associated with cognitive decline in middle-aged adults.
OBJECTIVES: The aim of this study was to examine the association between dephospho-uncarboxylated matrix Gla protein (dp-ucMGP), an indicator of vitamin K status, and cognitive decline, and the modifying role of 25(OH)D. DESIGN: Longitudinal study with six years follow-up. SETTING: Community based. PARTICIPANTS: 599 participants of the Longitudinal Aging Study Amsterdam (aged 55-65 years). MEASUREMENTS: Information processing speed and a composite Z-score by combining three domains of cognition reflecting general cognitive functioning. RESULTS: Generalized estimating equations (GEE) showed no significant associations between dp-ucMGP and decline in general cognitive functioning. Vitamin D modified the association between dp-ucMGP and speed of information processing (p<0.05). In the group with a 25(OH)D concentration > 50 nmol/l, the highest tertile of dp-ucMGP (>406 pmol/l), which corresponds to lower vitamin K levels, was associated with 1.5 higher score on information processing speed (p=0.023) as compared to the lowest tertile of dp-ucMGP. CONCLUSION: In contrast to our hypothesis, a suboptimal vitamin K was not associated with cognitive decline in middle-aged adults.
Authors: Martijn Huisman; Jan Poppelaars; Marleen van der Horst; Aartjan T F Beekman; Johannes Brug; Theo G van Tilburg; Dorly J H Deeg Journal: Int J Epidemiol Date: 2011-01-06 Impact factor: 7.196
Authors: Hannie C Comijs; Didi M W Kriegsman; Miranda G Dik; Dorly J H Deeg; Cees Jonker; Wim A B Stalman Journal: Arch Gerontol Geriatr Date: 2008-03-04 Impact factor: 3.250
Authors: M Kyla Shea; Jifan Wang; Kathryn Barger; Daniel E Weiner; Sarah L Booth; Stephen L Seliger; Amanda H Anderson; Rajat Deo; Harold I Feldman; Alan S Go; Jiang He; Ana C Ricardo; Manjula Kurella Tamura Journal: Curr Dev Nutr Date: 2022-06-24