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Literature DB >> 22111891

Drug release from electric-field-responsive nanoparticles.

Jun Ge¹, Evgenios Neofytou, Thomas J Cahill, Ramin E Beygui, Richard N Zare.

Abstract

We describe a new temperature and electric field dual-stimulus responsive nanoparticle system for programmed drug delivery. Nanoparticles of a conducting polymer (polypyrrole) are loaded with therapeutic pharmaceuticals and are subcutaneously localized in vivo with the assistance of a temperature-sensitive hydrogel (PLGA-PEG-PLGA). We have shown that drug release from the conductive nanoparticles is controlled by the application of a weak, external DC electric field. This approach represents a novel interactive drug delivery system that can show an externally tailored release profile with an excellent spatial, temporal, and dosage control.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2011 PMID： 22111891 PMCID： PMC3489921 DOI： 10.1021/nn203430m

Source DB: PubMed Journal: ACS Nano ISSN： 1936-0851 Impact factor: 15.881

28 in total

Review 1. Small-scale systems for in vivo drug delivery.

Authors: David A LaVan; Terry McGuire; Robert Langer
Journal: Nat Biotechnol Date: 2003-10 Impact factor: 54.908

2. Materials science. Smart biomaterials.

Authors: Daniel G Anderson; Jason A Burdick; Robert Langer
Journal: Science Date: 2004-09-24 Impact factor: 47.728

3. Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode.

Authors: Reecha Wadhwa; Carl F Lagenaur; Xinyan Tracy Cui
Journal: J Control Release Date: 2005-12-19 Impact factor: 9.776

4. Organic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function.

Authors: Daniel T Simon; Sindhulakshmi Kurup; Karin C Larsson; Ryusuke Hori; Klas Tybrandt; Michel Goiny; Edwin W H Jager; Magnus Berggren; Barbara Canlon; Agneta Richter-Dahlfors
Journal: Nat Mater Date: 2009-07-05 Impact factor: 43.841

5. Conducting-Polymer Nanotubes for Controlled Drug Release.

Authors: Mohammad Reza Abidian; Dong-Hwan Kim; David C Martin
Journal: Adv Mater Date: 2006-02-17 Impact factor: 30.849

6. A lipase-responsive vehicle using amphipathic polymer synthesized with the lipase as catalyst.

Authors: Jun Ge; Diannan Lu; Cheng Yang; Zheng Liu
Journal: Macromol Rapid Commun Date: 2011-01-21 Impact factor: 5.734

7. Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics.

Authors: Paul M George; Alvin W Lyckman; David A LaVan; Anita Hegde; Yuika Leung; Rupali Avasare; Chris Testa; Phillip M Alexander; Robert Langer; Mriganka Sur
Journal: Biomaterials Date: 2005-06 Impact factor: 12.479

8. Delivery of molecules into cells using carbon nanoparticles activated by femtosecond laser pulses.

Authors: Prerona Chakravarty; Wei Qian; Mostafa A El-Sayed; Mark R Prausnitz
Journal: Nat Nanotechnol Date: 2010-07-18 Impact factor: 39.213

9. In vivo evaluation of a novel electrically conductive polypyrrole/poly(D,L-lactide) composite and polypyrrole-coated poly(D,L-lactide-co-glycolide) membranes.

Authors: Zhaoxu Wang; Christophe Roberge; Lê H Dao; Ying Wan; Guixin Shi; Mahmoud Rouabhia; Robert Guidoin; Ze Zhang
Journal: J Biomed Mater Res A Date: 2004-07-01 Impact factor: 4.396

10. Targeted delivery of magnetic aerosol droplets to the lung.

Authors: Petra Dames; Bernhard Gleich; Andreas Flemmer; Kerstin Hajek; Nicole Seidl; Frank Wiekhorst; Dietmar Eberbeck; Iris Bittmann; Christian Bergemann; Thomas Weyh; Lutz Trahms; Joseph Rosenecker; Carsten Rudolph
Journal: Nat Nanotechnol Date: 2007-07-22 Impact factor: 39.213

63 in total

Drug release from electric-field-responsive nanoparticles.

Review 1. Small-scale systems for in vivo drug delivery.

2. Materials science. Smart biomaterials.

3. Electrochemically controlled release of dexamethasone from conducting polymer polypyrrole coated electrode.

4. Organic electronics for precise delivery of neurotransmitters to modulate mammalian sensory function.

5. Conducting-Polymer Nanotubes for Controlled Drug Release.

6. A lipase-responsive vehicle using amphipathic polymer synthesized with the lipase as catalyst.

7. Fabrication and biocompatibility of polypyrrole implants suitable for neural prosthetics.

8. Delivery of molecules into cells using carbon nanoparticles activated by femtosecond laser pulses.

9. In vivo evaluation of a novel electrically conductive polypyrrole/poly(D,L-lactide) composite and polypyrrole-coated poly(D,L-lactide-co-glycolide) membranes.

10. Targeted delivery of magnetic aerosol droplets to the lung.

Review 1. Advances in Biomaterials for Drug Delivery.

2. Kinetic modelling and bifurcation analysis of chemomechanically miniaturized gels under mechanical load.

Review 3. Stimuli-responsive nanocarriers for drug delivery.

Review 4. Design strategies for physical-stimuli-responsive programmable nanotherapeutics.

5. Enzyme-activated intracellular drug delivery with tubule clay nanoformulation.

Review 6. Application of biomaterials to advance induced pluripotent stem cell research and therapy.

7. Programmable and on-demand drug release using electrical stimulation.

8. Tunable Hydrogels: Introduction to the World of Smart Materials for Biomedical Applications.

9. Shape induced acid responsive heat triggered highly facilitated drug release by cube shaped magnetite nanoparticles.

Review 10. Implantable Sensors for Regenerative Medicine.