Shape induced acid responsive heat triggered highly facilitated drug release by cube shaped magnetite nanoparticles.

This paper reports a very simple yet better method for synthesis of cube shaped magnetite nanoparticles (MNPs) and their application in the drug delivery system (DDS). Structural analysis was done by XRD measurements to confirm the phase of the material, and morphological information was obtained through TEM analysis to confirm the shape and size of the particles. It has been shown that these particles can be decomposed in acid medium. These acid-decomposable magnetite nano-particles have been used for heat triggered, remote-controlled, on demand delivery and release of a cancer drug doxorubicin for research and therapeutic purposes. Here, we have shown that the pH stimulated and heat-triggered release of drug from our MNPs significantly enhances the release efficiency. In this case, we observe that pH induced release is far better in comparison to heat-triggered release. From these inspiring results, it may be expected that this methodology may become a significant step towards the development of a pH-sensitive heat triggered drug delivery system minimizing drug toxicity.