Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 In vitro activities of trioxaquines against Schistosoma mansoni.

Literature DB >> 19596887

In vitro activities of trioxaquines against Schistosoma mansoni.

Jérôme Boissier¹, Frédéric Coslédan, Anne Robert, Bernard Meunier.

Abstract

We report the in vitro activities of trioxaquines against larval and adult-stage schistosomes at 5 and 50 microg/ml, respectively. Such activities are equivalent to that of praziquantel, the major and rather unique drug currently used for the treatment of schistosomiasis. In this range of concentrations, artemisinin derivatives (artesunate and artemether) have no activity.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 2009 PMID： 19596887 PMCID： PMC2772302 DOI： 10.1128/AAC.00640-09

Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN： 0066-4804 Impact factor: 5.191

18 in total

1. Infectious disease. Medical helminthology in the 21st century.

Authors: D G Colley; P T LoVerde; L Savioli
Journal: Science Date: 2001-08-24 Impact factor: 47.728

Review 2. Recent investigations of artemether, a novel agent for the prevention of schistosomiasis japonica, mansoni and haematobia.

Authors: Shuhua Xiao; Marcel Tanner; Eliézer K N'Goran; Jürg Utzinger; Jacques Chollet; Robert Bergquist; Minggang Chen; Jiang Zheng
Journal: Acta Trop Date: 2002-05 Impact factor: 3.112

Review 3. Schistosomiasis--a century searching for chemotherapeutic drugs.

Authors: Gabriela Ribeiro-dos-Santos; Sergio Verjovski-Almeida; Luciana C C Leite
Journal: Parasitol Res Date: 2006-04-25 Impact factor: 2.289

4. The antimalarial drug artemisinin alkylates heme in infected mice.

Authors: Anne Robert; Françoise Benoit-Vical; Catherine Claparols; Bernard Meunier
Journal: Proc Natl Acad Sci U S A Date: 2005-09-09 Impact factor: 11.205

Review 5. Resistance of Schistosoma mansoni to praziquantel: is there a problem?

Authors: Michael J Doenhoff; John R Kusel; Gerald C Coles; Donato Cioli
Journal: Trans R Soc Trop Med Hyg Date: 2002 Sep-Oct Impact factor: 2.184

6. Experimental observations on the sex ratio of adult Schistosoma mansoni, with comments on the natural male bias.

Authors: J Boissier; H Moné
Journal: Parasitology Date: 2000-10 Impact factor: 3.234

7. Structural and morphological characterization of hemozoin produced by Schistosoma mansoni and Rhodnius prolixus.

Authors: Marcus F Oliveira; Stefan W Kycia; Ariel Gomez; Aaron J Kosar; D Scott Bohle; Ernst Hempelmann; Diego Menezes; Marcos André Vannier-Santos; Pedro L Oliveira; Sérgio T Ferreira
Journal: FEBS Lett Date: 2005-10-05 Impact factor: 4.124

8. Failure of standard treatment with praziquantel in two returned travelers with Schistosoma haematobium infection.

Authors: David Alonso; Jose Muñoz; Joaquim Gascón; Maria Eugenia Valls; Manuel Corachan
Journal: Am J Trop Med Hyg Date: 2006-02 Impact factor: 2.345

9. Schistosoma japonicum: In vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media.

Authors: Shu-Hua Xiao; Yu-Lin Wu; Marcel Tanner; Wen-Min Wu; Jürg Utzinger; Jin-Yan Mei; Bernard Scorneaux; Jacques Chollet; Zili Zhai
Journal: Parasitol Res Date: 2003-01-10 Impact factor: 2.289

10. Mefloquine--an aminoalcohol with promising antischistosomal properties in mice.

Authors: Jennifer Keiser; Jacques Chollet; Shu-Hua Xiao; Jin-Yan Mei; Pei-Ying Jiao; Jürg Utzinger; Marcel Tanner
Journal: PLoS Negl Trop Dis Date: 2009-01-06

14 in total

1. Isothermal microcalorimetry to study drugs against Schistosoma mansoni.

Authors: Theresia Manneck; Olivier Braissant; Yolanda Haggenmüller; Jennifer Keiser
Journal: J Clin Microbiol Date: 2011-01-26 Impact factor: 5.948

2. Ultrastructural analysis of miltefosine-induced surface membrane damage in adult Schistosoma mansoni BH strain worms.

Authors: Humberto Gonçalves Bertão; Renata Alexandre Ramos da Silva; Rafael José R Padilha; Mônica Camelo Pessôa de Azevedo Albuquerque; Gandhi Rádis-Baptista
Journal: Parasitol Res Date: 2012-01-04 Impact factor: 2.289

3. In vivo activity of aryl ozonides against Schistosoma species.

Authors: Jennifer Keiser; Katrin Ingram; Mireille Vargas; Jacques Chollet; Xiaofang Wang; Yuxiang Dong; Jonathan L Vennerstrom
Journal: Antimicrob Agents Chemother Date: 2011-11-21 Impact factor: 5.191

4. Polycyclic compounds by Ugi-Pictet-Spengler sequence.

Authors: Wei Wang; Sarah Ollio; Eberhardt Herdtweck; Alexander Dömling
Journal: J Org Chem Date: 2010-12-29 Impact factor: 4.354

5. In vitro and in vivo activity of 3-alkoxy-1,2-dioxolanes against Schistosoma mansoni.

Authors: Katrin Ingram; Charles E Schiaffo; Wantanee Sittiwong; Evan Benner; Patrick H Dussault; Jennifer Keiser
Journal: J Antimicrob Chemother Date: 2012-05-02 Impact factor: 5.790

6. Trioxaquine PA1259 alkylates heme in the blood-feeding parasite Schistosoma mansoni.

Authors: Vincent Pradines; Julien Portela; Jérôme Boissier; Frédéric Coslédan; Bernard Meunier; Anne Robert
Journal: Antimicrob Agents Chemother Date: 2011-02-07 Impact factor: 5.191

Review 7. Chemotherapy for human schistosomiasis: how far have we come? What's new? Where do we go from here?

Authors: Godwin Akpeko Dziwornu; Henrietta Dede Attram; Samuel Gachuhi; Kelly Chibale
Journal: RSC Med Chem Date: 2020-04-06

8. Mn-, Fe-, and Co-Catalyzed Radical Hydrofunctionalizations of Olefins.

Authors: Steven W M Crossley; Carla Obradors; Ruben M Martinez; Ryan A Shenvi
Journal: Chem Rev Date: 2016-07-27 Impact factor: 60.622

9. Antischistosomal activity of trioxaquines: in vivo efficacy and mechanism of action on Schistosoma mansoni.

Authors: Julien Portela; Jérôme Boissier; Benjamin Gourbal; Vincent Pradines; Vincent Collière; Frédéric Coslédan; Bernard Meunier; Anne Robert
Journal: PLoS Negl Trop Dis Date: 2012-02-14

10. Evidence for the contribution of the hemozoin synthesis pathway of the murine Plasmodium yoelii to the resistance to artemisinin-related drugs.

Authors: Benoit Witkowski; Joel Lelièvre; Marie-Laure Nicolau-Travers; Xavier Iriart; Patrice Njomnang Soh; Fatima Bousejra-Elgarah; Bernard Meunier; Antoine Berry; Françoise Benoit-Vical
Journal: PLoS One Date: 2012-03-05 Impact factor: 3.240