Literature DB >> 22094250

The Two Faces of NF-κB Signaling in Cancer Development and Therapy.

Ulf Klein1, Sankar Ghosh.   

Abstract

Constitutive activation of NF-κB signaling can promote oncogenesis, providing a rationale for anticancer strategies that inhibit NF-κB signaling. Two recent publications in Genes & Development provide evidence that, in contexts where prosurvival signals derive from other oncogenes, NF-κB activity instead enhances sensitivity to cytotoxic chemotherapy, thereby exerting a tumor-suppressor function. 2011 Elsevier Inc. All rights reserved.

Entities:  

Year:  2011        PMID： 22094250      PMCID： PMC3245902          DOI： 10.1016/j.ccr.2011.10.026

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

Review 1.  The essence of senescence.

Authors:  Thomas Kuilman; Chrysiis Michaloglou; Wolter J Mooi; Daniel S Peeper
Journal:  Genes Dev       Date:  2010-11-15       Impact factor: 11.361

Review 2.  Shared principles in NF-kappaB signaling.

Authors:  Matthew S Hayden; Sankar Ghosh
Journal:  Cell       Date:  2008-02-08       Impact factor: 41.582

Review 3.  Malignant pirates of the immune system.

Authors:  Lixin Rui; Roland Schmitz; Michele Ceribelli; Louis M Staudt
Journal:  Nat Immunol       Date:  2011-09-20       Impact factor: 25.606

4.  A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy.

Authors:  Clemens A Schmitt; Jordan S Fridman; Meng Yang; Soyoung Lee; Eugene Baranov; Robert M Hoffman; Scott W Lowe
Journal:  Cell       Date:  2002-05-03       Impact factor: 41.582

5.  Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity.

Authors:  Yuchen Chien; Claudio Scuoppo; Xiaowo Wang; Xueping Fang; Brian Balgley; Jessica E Bolden; Prem Premsrirut; Weijun Luo; Agustin Chicas; Cheng S Lee; Scott C Kogan; Scott W Lowe
Journal:  Genes Dev       Date:  2011-10-06       Impact factor: 11.361

6.  Opposing roles of NF-κB in anti-cancer treatment outcome unveiled by cross-species investigations.

Authors:  Hua Jing; Julia Kase; Jan R Dörr; Maja Milanovic; Dido Lenze; Michael Grau; Gregor Beuster; Sujuan Ji; Maurice Reimann; Peter Lenz; Michael Hummel; Bernd Dörken; Georg Lenz; Claus Scheidereit; Clemens A Schmitt; Soyoung Lee
Journal:  Genes Dev       Date:  2011-10-06       Impact factor: 11.361

Review 7.  Inflammation meets cancer, with NF-κB as the matchmaker.

Authors:  Yinon Ben-Neriah; Michael Karin
Journal:  Nat Immunol       Date:  2011-07-19       Impact factor: 25.606

Review 8.  Senescence-messaging secretome: SMS-ing cellular stress.

Authors:  Thomas Kuilman; Daniel S Peeper
Journal:  Nat Rev Cancer       Date:  2009-01-09       Impact factor: 60.716

9.  Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor.

Authors:  Jean-Philippe Coppé; Christopher K Patil; Francis Rodier; Yu Sun; Denise P Muñoz; Joshua Goldstein; Peter S Nelson; Pierre-Yves Desprez; Judith Campisi
Journal:  PLoS Biol       Date:  2008-12-02       Impact factor: 8.029
  9 in total
  13 in total

1.  NF-κB directly regulates Fas transcription to modulate Fas-mediated apoptosis and tumor suppression.

Authors:  Feiyan Liu; Kankana Bardhan; Dafeng Yang; Muthusamy Thangaraju; Vadivel Ganapathy; Jennifer L Waller; Georgia B Liles; Jeffrey R Lee; Kebin Liu
Journal:  J Biol Chem       Date:  2012-06-05       Impact factor: 5.157

2.  Lymphotoxin β receptor mediates caspase-dependent tumor cell apoptosis in vitro and tumor suppression in vivo despite induction of NF-κB activation.

Authors:  Xiaolin Hu; Mary A Zimmerman; Kankana Bardhan; Dafeng Yang; Jennifer L Waller; Georgia B Liles; Jeffrey R Lee; Raphael Pollock; Dina Lev; Carl F Ware; Ellen Garber; Veronique Bailly; Jeffrey L Browning; Kebin Liu
Journal:  Carcinogenesis       Date:  2013-01-24       Impact factor: 4.944

3.  Tumor Suppressor Gene XEDAR Promotes Differentiation and Suppresses Proliferation and Migration of Gastric Cancer Cells Through Upregulating the RELA/LXRα Axis and Deactivating the Wnt/β-Catenin Pathway.

Authors:  Xinwu Zhang; Di Zhang; Xiaoli Sun; Shunle Li; Yun Sun; Hongjun Zhai
Journal:  Cell Transplant       Date:  2021 Jan-Dec       Impact factor: 4.064

4.  Loss of Nfkb1 leads to early onset aging.

Authors:  Giovanna M Bernal; Joshua S Wahlstrom; Clayton D Crawley; Kirk E Cahill; Peter Pytel; Hua Liang; Shijun Kang; Ralph R Weichselbaum; Bakhtiar Yamini
Journal:  Aging (Albany NY)       Date:  2014-11       Impact factor: 5.682

5.  Nuclear factor-kappaB sensitizes to benzyl isothiocyanate-induced antiproliferation in p53-deficient colorectal cancer cells.

Authors:  N Abe; D-X Hou; S Munemasa; Y Murata; Y Nakamura
Journal:  Cell Death Dis       Date:  2014-11-20       Impact factor: 8.469

6.  NF-κB functions as a molecular link between tumor cells and Th1/Tc1 T cells in the tumor microenvironment to exert radiation-mediated tumor suppression.

Authors:  Priscilla S Simon; Kankana Bardhan; May R Chen; Amy V Paschall; Chunwan Lu; Roni J Bollag; Feng-Chong Kong; JianYue Jin; Feng-Ming Kong; Jennifer L Waller; Raphael E Pollock; Kebin Liu
Journal:  Oncotarget       Date:  2016-04-26

7.  Comparative Gene Expression Profiling of Primary and Metastatic Renal Cell Carcinoma Stem Cell-Like Cancer Cells.

Authors:  Mohammed I Khan; Anna M Czarnecka; Sławomir Lewicki; Igor Helbrecht; Klaudia Brodaczewska; Irena Koch; Robert Zdanowski; Magdalena Król; Cezary Szczylik
Journal:  PLoS One       Date:  2016-11-03       Impact factor: 3.240

8.  Nucleophosmin Mutations Induce Chemosensitivity in THP-1 Leukemia Cells by Suppressing NF-κB Activity and Regulating Bax/Bcl-2 Expression.

Authors:  Shuaishuai Zhang; Fengxian Qin; Liyuan Yang; Jingrong Xian; Qin Zou; Hongjun Jin; Lu Wang; Ling Zhang
Journal:  J Cancer       Date:  2016-11-25       Impact factor: 4.207

9.  RelA regulates CXCL1/CXCR2-dependent oncogene-induced senescence in murine Kras-driven pancreatic carcinogenesis.

Authors:  Marina Lesina; Sonja Maria Wörmann; Jennifer Morton; Kalliope Nina Diakopoulos; Olga Korneeva; Margit Wimmer; Henrik Einwächter; Jan Sperveslage; Ihsan Ekin Demir; Timo Kehl; Dieter Saur; Bence Sipos; Mathias Heikenwälder; Jörg Manfred Steiner; Timothy Cragin Wang; Owen J Sansom; Roland Michael Schmid; Hana Algül
Journal:  J Clin Invest       Date:  2016-07-25       Impact factor: 14.808

10.  Loss of the oncogenic phosphatase PRL-3 promotes a TNF-R1 feedback loop that mediates triple-negative breast cancer growth.

Authors:  H H Gari; G D DeGala; M S Lucia; J R Lambert
Journal:  Oncogenesis       Date:  2016-08-15       Impact factor: 7.485
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