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Literature DB >> 21078816

The essence of senescence.

Thomas Kuilman¹, Chrysiis Michaloglou, Wolter J Mooi, Daniel S Peeper.

Abstract

Almost half a century after the first reports describing the limited replicative potential of primary cells in culture, there is now overwhelming evidence for the existence of "cellular senescence" in vivo. It is being recognized as a critical feature of mammalian cells to suppress tumorigenesis, acting alongside cell death programs. Here, we review the various features of cellular senescence and discuss their contribution to tumor suppression. Additionally, we highlight the power and limitations of the biomarkers currently used to identify senescent cells in vitro and in vivo.

Entities: Disease Species

Mesh：

Substances：
Biomarkers

Year: 2010 PMID： 21078816 PMCID： PMC2975923 DOI： 10.1101/gad.1971610

Source DB: PubMed Journal: Genes Dev ISSN： 0890-9369 Impact factor: 11.361

209 in total

1. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.

Authors: Hui-Kuan Lin; Zhenbang Chen; Guocan Wang; Caterina Nardella; Szu-Wei Lee; Chia-Hsin Chan; Chan-Hsin Chan; Wei-Lei Yang; Jing Wang; Ainara Egia; Keiichi I Nakayama; Carlos Cordon-Cardo; Julie Teruya-Feldstein; Pier Paolo Pandolfi
Journal: Nature Date: 2010-03-18 Impact factor: 49.962

2. Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma.

Authors: David Schrama; Hermann Kneitz; Christoph Willmes; Christian Adam; Roland Houben; Jürgen C Becker
Journal: J Invest Dermatol Date: 2009-10-15 Impact factor: 8.551

Review 3. Telomeres and telomerase in cancer.

Authors: Steven E Artandi; Ronald A DePinho
Journal: Carcinogenesis Date: 2009-11-03 Impact factor: 4.944

4. Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence.

Authors: Agustin Chicas; Xiaowo Wang; Chaolin Zhang; Mila McCurrach; Zhen Zhao; Ozlem Mert; Ross A Dickins; Masashi Narita; Michael Zhang; Scott W Lowe
Journal: Cancer Cell Date: 2010-04-13 Impact factor: 31.743

Review 5. Senescence in tumours: evidence from mice and humans.

Authors: Manuel Collado; Manuel Serrano
Journal: Nat Rev Cancer Date: 2010-01 Impact factor: 60.716

6. Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.

Authors: Maurice Reimann; Soyoung Lee; Christoph Loddenkemper; Jan R Dörr; Vedrana Tabor; Peter Aichele; Harald Stein; Bernd Dörken; Thomas Jenuwein; Clemens A Schmitt
Journal: Cancer Cell Date: 2010-03-16 Impact factor: 31.743

7. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.

Authors: Andrea Alimonti; Caterina Nardella; Zhenbang Chen; John G Clohessy; Arkaitz Carracedo; Lloyd C Trotman; Ke Cheng; Shohreh Varmeh; Sara C Kozma; George Thomas; Erika Rosivatz; Rudiger Woscholski; Francesco Cognetti; Howard I Scher; Pier Paolo Pandolfi
Journal: J Clin Invest Date: 2010-02-08 Impact factor: 14.808

8. Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

Authors: Stefano Campaner; Mirko Doni; Per Hydbring; Alessandro Verrecchia; Lucia Bianchi; Domenico Sardella; Thomas Schleker; Daniele Perna; Susanna Tronnersjö; Matilde Murga; Oscar Fernandez-Capetillo; Mariano Barbacid; Lars-Gunnar Larsson; Bruno Amati
Journal: Nat Cell Biol Date: 2009-12-13 Impact factor: 28.824

9. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo.

Authors: Florence Debacq-Chainiaux; Jorge D Erusalimsky; Judith Campisi; Olivier Toussaint
Journal: Nat Protoc Date: 2009 Impact factor: 13.491

10. Feedback between p21 and reactive oxygen production is necessary for cell senescence.

Authors: João F Passos; Glyn Nelson; Chunfang Wang; Torsten Richter; Cedric Simillion; Carole J Proctor; Satomi Miwa; Sharon Olijslagers; Jennifer Hallinan; Anil Wipat; Gabriele Saretzki; Karl Lenhard Rudolph; Tom B L Kirkwood; Thomas von Zglinicki
Journal: Mol Syst Biol Date: 2010-02-16 Impact factor: 11.429

815 in total

1. Ageing: Old cells under attack.

Authors: Daniel S Peeper
Journal: Nature Date: 2011-11-09 Impact factor: 49.962

2. p63-microRNA feedback in keratinocyte senescence.

Authors: Pia Rivetti di Val Cervo; Anna Maria Lena; Milena Nicoloso; Simona Rossi; Mara Mancini; Huiqing Zhou; Gaelle Saintigny; Elena Dellambra; Teresa Odorisio; Christian Mahé; George Adrian Calin; Eleonora Candi; Gerry Melino
Journal: Proc Natl Acad Sci U S A Date: 2012-01-06 Impact factor: 11.205

3. Growth inhibition by miR-519 via multiple p21-inducing pathways.

Authors: Kotb Abdelmohsen; Subramanya Srikantan; Kumiko Tominaga; Min-Ju Kang; Yael Yaniv; Jennifer L Martindale; Xiaoling Yang; Sung-Soo Park; Kevin G Becker; Murugan Subramanian; Stuart Maudsley; Ashish Lal; Myriam Gorospe
Journal: Mol Cell Biol Date: 2012-04-30 Impact factor: 4.272

The essence of senescence.

1. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence.

2. Lack of correlation between IGFBP7 expression and BRAF mutational status in melanoma.

Review 3. Telomeres and telomerase in cancer.

4. Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence.

Review 5. Senescence in tumours: evidence from mice and humans.

6. Tumor stroma-derived TGF-beta limits myc-driven lymphomagenesis via Suv39h1-dependent senescence.

7. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis.

8. Cdk2 suppresses cellular senescence induced by the c-myc oncogene.

9. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo.

10. Feedback between p21 and reactive oxygen production is necessary for cell senescence.

1. Ageing: Old cells under attack.

2. p63-microRNA feedback in keratinocyte senescence.

3. Growth inhibition by miR-519 via multiple p21-inducing pathways.

4. Oncogene-induced senescence results in marked metabolic and bioenergetic alterations.

5. Signalling the end of the line.

6. Senescence-associated microRNAs linked to tumorigenesis.

7. Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.

8. Techniques to Induce and Quantify Cellular Senescence.

9. Subcellular distribution and activity of mechanistic target of rapamycin in aged retinal pigment epithelium.

Review 10. TGF-β1 Signaling and Tissue Fibrosis.