Literature DB >> 22068975

Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and function.

Chaoxuan Li1, Feifei Zhang, Wendy L Kelly.   

Abstract

The seventh residue of thiostrepton is predicted to be critical for antibacterial activity. Substitution of Thr7 in the thiostrepton precursor peptide disrupts both biological activity and the successful biosynthesis of analogs. This journal is © The Royal Society of Chemistry 2012

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Year:  2011        PMID： 22068975      PMCID： PMC3849712          DOI： 10.1039/c1cc14281j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  18 in total

1.  Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur.

Authors:  C S Bond; M P Shaw; M S Alphey; W N Hunter
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2001-04-24

Review 2.  Thiopeptide antibiotics.

Authors:  Mark C Bagley; James W Dale; Eleanor A Merritt; Xin Xiong
Journal:  Chem Rev       Date:  2005-02       Impact factor: 60.622

3.  Thirteen posttranslational modifications convert a 14-residue peptide into the antibiotic thiocillin.

Authors:  Laura C Wieland Brown; Michael G Acker; Jon Clardy; Christopher T Walsh; Michael A Fischbach
Journal:  Proc Natl Acad Sci U S A       Date:  2009-02-05       Impact factor: 11.205

4.  Micrococcin, an antibacterial substance formed by a strain of Micrococcus.

Authors:  T L SU
Journal:  Br J Exp Pathol       Date:  1948-10

5.  Streptomyces laurentii, a new species producing thiostrepton.

Authors:  W H Trejo; L D Dean; J Pluscec; E Meyers; W E Brown
Journal:  J Antibiot (Tokyo)       Date:  1977-08       Impact factor: 2.649

6.  Reexamination of the 1H and 13C NMR spectral assignments of thiostrepton.

Authors:  U Mocek; J M Beale; H G Floss
Journal:  J Antibiot (Tokyo)       Date:  1989-11       Impact factor: 2.649

7.  Studies on the biosynthesis of thiostrepton: 4-(1-hydroxyethyl)quinoline-2-carboxylate as a free intermediate on the pathway to the quinaldic acid moiety.

Authors:  N D Priestley; T M Smith; P R Shipley; H G Floss
Journal:  Bioorg Med Chem       Date:  1996-07       Impact factor: 3.641

8.  Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin.

Authors:  Joerg M Harms; Daniel N Wilson; Frank Schluenzen; Sean R Connell; Torsten Stachelhaus; Zaneta Zaborowska; Christian M T Spahn; Paola Fucini
Journal:  Mol Cell       Date:  2008-04-11       Impact factor: 17.970

9.  Inhibition by siomycin and thiostrepton of both aminoacyl-tRNA and factor G binding to ribosomes.

Authors:  J Modolell; B Cabrer; A Parmeggiani; D Vazquez
Journal:  Proc Natl Acad Sci U S A       Date:  1971-08       Impact factor: 11.205

10.  The translation initiation functions of IF2: targets for thiostrepton inhibition.

Authors:  Letizia Brandi; Stefano Marzi; Attilio Fabbretti; Carola Fleischer; Walter E Hill; Claudio O Gualerzi; J Stephen Lodmell
Journal:  J Mol Biol       Date:  2004-01-23       Impact factor: 5.469
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  10 in total

Review 1.  Elucidating and engineering thiopeptide biosynthesis.

Authors:  Philip R Bennallack; Joel S Griffitts
Journal:  World J Microbiol Biotechnol       Date:  2017-05-11       Impact factor: 3.312

2.  In Vitro Biosynthesis and Substrate Tolerance of the Plantazolicin Family of Natural Products.

Authors:  Caitlin D Deane; Brandon J Burkhart; Patricia M Blair; Jonathan I Tietz; Alice Lin; Douglas A Mitchell
Journal:  ACS Chem Biol       Date:  2016-06-16       Impact factor: 5.100

3.  Engineering unnatural variants of plantazolicin through codon reprogramming.

Authors:  Caitlin D Deane; Joel O Melby; Katie J Molohon; Aziz R Susarrey; Douglas A Mitchell
Journal:  ACS Chem Biol       Date:  2013-07-03       Impact factor: 5.100

4.  Biosynthesis of the Thiopeptins and Identification of an F420H2-Dependent Dehydropiperidine Reductase.

Authors:  Hiro Ichikawa; Ghader Bashiri; Wendy L Kelly
Journal:  J Am Chem Soc       Date:  2018-08-17       Impact factor: 15.419

5.  Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.

Authors:  Feifei Zhang; Wendy L Kelly
Journal:  ACS Chem Biol       Date:  2015-01-20       Impact factor: 5.100

6.  Thiostrepton Variants Containing a Contracted Quinaldic Acid Macrocycle Result from Mutagenesis of the Second Residue.

Authors:  Feifei Zhang; Chaoxuan Li; Wendy L Kelly
Journal:  ACS Chem Biol       Date:  2015-12-14       Impact factor: 5.100

7.  Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants.

Authors:  Travis S Young; Pieter C Dorrestein; Christopher T Walsh
Journal:  Chem Biol       Date:  2012-12-21

8.  Ribosomally synthesized and post-translationally modified peptide natural products: new insights into the role of leader and core peptides during biosynthesis.

Authors:  Xiao Yang; Wilfred A van der Donk
Journal:  Chemistry       Date:  2013-05-10       Impact factor: 5.236

Review 9.  YcaO-Dependent Posttranslational Amide Activation: Biosynthesis, Structure, and Function.

Authors:  Brandon J Burkhart; Christopher J Schwalen; Greg Mann; James H Naismith; Douglas A Mitchell
Journal:  Chem Rev       Date:  2017-03-03       Impact factor: 60.622

Review 10.  Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Authors:  Paul G Arnison; Mervyn J Bibb; Gabriele Bierbaum; Albert A Bowers; Tim S Bugni; Grzegorz Bulaj; Julio A Camarero; Dominic J Campopiano; Gregory L Challis; Jon Clardy; Paul D Cotter; David J Craik; Michael Dawson; Elke Dittmann; Stefano Donadio; Pieter C Dorrestein; Karl-Dieter Entian; Michael A Fischbach; John S Garavelli; Ulf Göransson; Christian W Gruber; Daniel H Haft; Thomas K Hemscheidt; Christian Hertweck; Colin Hill; Alexander R Horswill; Marcel Jaspars; Wendy L Kelly; Judith P Klinman; Oscar P Kuipers; A James Link; Wen Liu; Mohamed A Marahiel; Douglas A Mitchell; Gert N Moll; Bradley S Moore; Rolf Müller; Satish K Nair; Ingolf F Nes; Gillian E Norris; Baldomero M Olivera; Hiroyasu Onaka; Mark L Patchett; Joern Piel; Martin J T Reaney; Sylvie Rebuffat; R Paul Ross; Hans-Georg Sahl; Eric W Schmidt; Michael E Selsted; Konstantin Severinov; Ben Shen; Kaarina Sivonen; Leif Smith; Torsten Stein; Roderich D Süssmuth; John R Tagg; Gong-Li Tang; Andrew W Truman; John C Vederas; Christopher T Walsh; Jonathan D Walton; Silke C Wenzel; Joanne M Willey; Wilfred A van der Donk
Journal:  Nat Prod Rep       Date:  2013-01       Impact factor: 13.423
  10 in total

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