Literature DB >> 11320328

Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur.

C S Bond1, M P Shaw, M S Alphey, W N Hunter.   

Abstract

The structure of a tetragonal crystal form of thiostrepton has been solved using the anomalous dispersive effects of five S atoms from high-redundancy data collected to 1.33 A resolution at the Cu Kalpha wavelength. Data measured to 1.02 A resolution with a synchrotron source were used for refinement. Details of the molecular structure, intramolecular and intermolecular interactions are given.

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Year:  2001        PMID： 11320328     DOI： 10.1107/s0907444901003134

Source DB:  PubMed          Journal:  Acta Crystallogr D Biol Crystallogr        ISSN： 0907-4449


  13 in total

1.  Manipulation of thiocillin variants by prepeptide gene replacement: structure, conformation, and activity of heterocycle substitution mutants.

Authors:  Albert A Bowers; Michael G Acker; Alexander Koglin; Christopher T Walsh
Journal:  J Am Chem Soc       Date:  2010-06-02       Impact factor: 15.419

2.  Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and function.

Authors:  Chaoxuan Li; Feifei Zhang; Wendy L Kelly
Journal:  Chem Commun (Camb)       Date:  2011-11-08       Impact factor: 6.222

Review 3.  How thiostrepton was made in the laboratory.

Authors:  K C Nicolaou
Journal:  Angew Chem Int Ed Engl       Date:  2012-12-03       Impact factor: 15.336

4.  Structural basis for antibiotic recognition by the TipA class of multidrug-resistance transcriptional regulators.

Authors:  Jan D Kahmann; Hans-Jürgen Sass; Martin G Allan; Haruo Seto; Charles J Thompson; Stephan Grzesiek
Journal:  EMBO J       Date:  2003-04-15       Impact factor: 11.598

5.  Structure-activity relationships of thiostrepton derivatives: implications for rational drug design.

Authors:  Antje Wolf; Sebastian Schoof; Sascha Baumann; Hans-Dieter Arndt; Karl N Kirschner
Journal:  J Comput Aided Mol Des       Date:  2014-10-04       Impact factor: 3.686

6.  Saturation mutagenesis of TsrA Ala4 unveils a highly mutable residue of thiostrepton A.

Authors:  Feifei Zhang; Wendy L Kelly
Journal:  ACS Chem Biol       Date:  2015-01-20       Impact factor: 5.100

7.  Structural basis and dynamics of multidrug recognition in a minimal bacterial multidrug resistance system.

Authors:  Judith Habazettl; Martin Allan; Pernille Rose Jensen; Hans-Jürgen Sass; Charles J Thompson; Stephan Grzesiek
Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-08       Impact factor: 11.205

8.  Thiostrepton-resistant mutants of Thermus thermophilus.

Authors:  Dale M Cameron; Jill Thompson; Steven T Gregory; Paul E March; Albert E Dahlberg
Journal:  Nucleic Acids Res       Date:  2004-06-15       Impact factor: 16.971

9.  L11 domain rearrangement upon binding to RNA and thiostrepton studied by NMR spectroscopy.

Authors:  Hendrik R A Jonker; Serge Ilin; S Kaspar Grimm; Jens Wöhnert; Harald Schwalbe
Journal:  Nucleic Acids Res       Date:  2006-12-14       Impact factor: 16.971

10.  A Multiplexed Cell-Based Assay for the Identification of Modulators of Pre-Membrane Processing as a Target against Dengue Virus.

Authors:  Zachary D Stolp; Cameron A Smurthwaite; Connor Reed; Wesley Williams; Andre Dharmawan; Hakim Djaballah; Roland Wolkowicz
Journal:  J Biomol Screen       Date:  2015-02-27
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