Nasim Maleki1, Weiying Dai, David C Alsop. 1. Department of Radiology, Children's Hospital Boston, 300 Longwood Ave, Boston, MA 02115, USA. nasim.maleki@childrens.harvard.edu
Abstract
OBJECT: To present an algorithm for optimization of background suppression pulse timing for arterial spin labeling (ASL) perfusion imaging. MATERIALS AND METHODS: An algorithm for optimization of background suppression pulse timing is proposed. Numerical optimization of timing of the background suppression pulses is investigated in both constrained and unconstrained ASL sequences. The performance of the parameters from the algorithm is evaluated in phantom and also in vivo in five human subjects. RESULTS: The background signal is suppressed to less than 1% across a broad range of T1s with a modest number of inversion pulses using the timings acquired from the numerical optimization algorithm proposed in this study. The performance of the parameters from the algorithm is also confirmed in vivo. CONCLUSION: Successful background suppression over a broad range of tissues is achievable. Values for optimal pulse timing in both pulsed and continuous ASL studies are reported to facilitate sequence design with different labeling parameters.
OBJECT: To present an algorithm for optimization of background suppression pulse timing for arterial spin labeling (ASL) perfusion imaging. MATERIALS AND METHODS: An algorithm for optimization of background suppression pulse timing is proposed. Numerical optimization of timing of the background suppression pulses is investigated in both constrained and unconstrained ASL sequences. The performance of the parameters from the algorithm is evaluated in phantom and also in vivo in five human subjects. RESULTS: The background signal is suppressed to less than 1% across a broad range of T1s with a modest number of inversion pulses using the timings acquired from the numerical optimization algorithm proposed in this study. The performance of the parameters from the algorithm is also confirmed in vivo. CONCLUSION: Successful background suppression over a broad range of tissues is achievable. Values for optimal pulse timing in both pulsed and continuous ASL studies are reported to facilitate sequence design with different labeling parameters.
Authors: María A Fernández-Seara; Ze Wang; Jiongjiong Wang; Heng-Yi Rao; Matthias Guenther; David A Feinberg; John A Detre Journal: Magn Reson Med Date: 2005-11 Impact factor: 4.668
Authors: G Lai; A Mahadevan; D Hackney; P C Warnke; F Nigim; E Kasper; E T Wong; B S Carter; C C Chen Journal: AJNR Am J Neuroradiol Date: 2015-10-01 Impact factor: 3.825
Authors: Joshua S Greer; Xinzeng Wang; Yiming Wang; Marco C Pinho; Joseph A Maldjian; Ivan Pedrosa; Ananth J Madhuranthakam Journal: Magn Reson Med Date: 2019-06-23 Impact factor: 4.668
Authors: Sudipto Dolui; Marta Vidorreta; Ze Wang; Ilya M Nasrallah; Abass Alavi; David A Wolk; John A Detre Journal: Hum Brain Mapp Date: 2017-07-24 Impact factor: 5.038