PURPOSE: In response to the increased risk of radiological terrorist attack, a network of Centers for Medical Countermeasures against Radiation (CMCR) has been established in the United States, focusing on evaluating animal model responses to uniform, relatively homogenous whole- or partial-body radiation exposures at relatively high dose rates. The success of such studies is dependent not only on robust animal models but on accurate and reproducible dosimetry within and across CMCR. To address this issue, the Education and Training Core of the Duke University School of Medicine CMCR organised a one-day workshop on small animal dosimetry. Topics included accuracy in animal dosimetry accuracy, characteristics and differences of cesium-137 and X-ray irradiators, methods for dose measurement, and design of experimental irradiation geometries for uniform dose distributions. This paper summarises the information presented and discussed. CONCLUSIONS: Without ensuring accurate and reproducible dosimetry the development and assessment of the efficacy of putative countermeasures will not prove successful. Radiation physics support is needed, but is often the weakest link in the small animal dosimetry chain. We recommend: (i) A user training program for new irradiator users, (ii) subsequent training updates, and (iii) the establishment of a national small animal dosimetry center for all CMCR members.
PURPOSE: In response to the increased risk of radiological terrorist attack, a network of Centers for Medical Countermeasures against Radiation (CMCR) has been established in the United States, focusing on evaluating animal model responses to uniform, relatively homogenous whole- or partial-body radiation exposures at relatively high dose rates. The success of such studies is dependent not only on robust animal models but on accurate and reproducible dosimetry within and across CMCR. To address this issue, the Education and Training Core of the Duke University School of Medicine CMCR organised a one-day workshop on small animal dosimetry. Topics included accuracy in animal dosimetry accuracy, characteristics and differences of cesium-137 and X-ray irradiators, methods for dose measurement, and design of experimental irradiation geometries for uniform dose distributions. This paper summarises the information presented and discussed. CONCLUSIONS: Without ensuring accurate and reproducible dosimetry the development and assessment of the efficacy of putative countermeasures will not prove successful. Radiation physics support is needed, but is often the weakest link in the small animal dosimetry chain. We recommend: (i) A user training program for new irradiator users, (ii) subsequent training updates, and (iii) the establishment of a national small animal dosimetry center for all CMCR members.
Authors: Samuel L Brady; Rathnayaka Gunasingha; Terry T Yoshizumi; Calvin R Howell; Alexander S Crowell; Brent Fallin; Anton P Tonchev; Mark W Dewhirst Journal: Phys Med Biol Date: 2010-08-06 Impact factor: 3.609
Authors: C Norman Coleman; Helen B Stone; George A Alexander; Mary Helen Barcellos-Hoff; Joel S Bedford; Robert G Bristow; Joseph R Dynlacht; Zvi Fuks; Lester S Gorelic; Richard P Hill; Michael C Joiner; Fei-Fei Liu; William H McBride; W Gillies McKenna; Simon N Powell; Michael E C Robbins; Sara Rockwell; Peter B Schiff; Edward G Shaw; Dietmar W Siemann; Elizabeth L Travis; Paul E Wallner; Rosemary S L Wong; Elaine M Zeman Journal: Radiat Res Date: 2003-12 Impact factor: 2.841
Authors: Andrew J Leiker; William DeGraff; Rajani Choudhuri; Anastasia L Sowers; Angela Thetford; John A Cook; Carter Van Waes; James B Mitchell Journal: Clin Cancer Res Date: 2015-02-27 Impact factor: 12.531
Authors: J Hartmann; J Wölfelschneider; C Stache; R Buslei; A Derer; M Schwarz; T Bäuerle; R Fietkau; U S Gaipl; C Bert; A Hölsken; B Frey Journal: Strahlenther Onkol Date: 2016-07-11 Impact factor: 3.621
Authors: Thomas M Seed; Shiyun Xiao; Nancy Manley; Janko Nikolich-Zugich; Jason Pugh; Marcel Van den Brink; Yoko Hirabayashi; Koji Yasutomo; Atsushi Iwama; Shigeo Koyasu; Ivo Shterev; Gregory Sempowski; Francesca Macchiarini; Kei Nakachi; Keith C Kunugi; Clifford G Hammer; Lawrence A Dewerd Journal: Int J Radiat Biol Date: 2015-11-17 Impact factor: 2.694
Authors: Matthew D Belley; Chu Wang; Giao Nguyen; Rathnayaka Gunasingha; Nelson J Chao; Benny J Chen; Mark W Dewhirst; Terry T Yoshizumi Journal: Med Phys Date: 2014-03 Impact factor: 4.071
Authors: Noora Ba Sunbul; Ibrahim Oraiqat; Benjamin Rosen; Cameron Miller; Christopher Meert; Martha M Matuszak; Shaun Clarke; Sara Pozzi; Jean M Moran; Issam El Naqa Journal: Med Phys Date: 2021-02-06 Impact factor: 4.071