BACKGROUND: Anastomotic complications after low anterior resection are associated with perianastomotic ischemia. Smoking is one of the main causes of microvascular disease that is correlated with tissue ischemia. The purpose of the present study was to assess the impact of smoking on anastomotic complications after low anterior resection in rectal cancer patients. METHODS: Between January 2005 and December 2008, 412 patients underwent low anterior resection for rectal cancers by a single surgeon at Seoul National University Hospital. Excluded from this series were 197 patients with postoperative radiation therapy, cancers that were located above 10 cm from the anal verge, or lack of medical records, and the remaining 215 patients were included for analysis. Significant variables in the univariate analysis were subsequently subject to multivariate analysis for identification of risk factors for complications. RESULTS: The rate of anastomotic complications was 10.7% (23 of 215 patients). Univariate analysis showed that male gender, body mass index higher than 25 kg/m(2), smoking history, smoking amount, type of operation, and presence of a protective stoma were associated with anastomotic complications. In multivariate analysis, a history of heavy smoking was a significant risk factor for anastomotic complications. CONCLUSIONS: A history of heavy smoking (more than 40 pack-years) is an independently significant risk factor for anastomotic complications after low anterior resection in rectal cancer patients.
BACKGROUND:Anastomotic complications after low anterior resection are associated with perianastomotic ischemia. Smoking is one of the main causes of microvascular disease that is correlated with tissue ischemia. The purpose of the present study was to assess the impact of smoking on anastomotic complications after low anterior resection in rectal cancerpatients. METHODS: Between January 2005 and December 2008, 412 patients underwent low anterior resection for rectal cancers by a single surgeon at Seoul National University Hospital. Excluded from this series were 197 patients with postoperative radiation therapy, cancers that were located above 10 cm from the anal verge, or lack of medical records, and the remaining 215 patients were included for analysis. Significant variables in the univariate analysis were subsequently subject to multivariate analysis for identification of risk factors for complications. RESULTS: The rate of anastomotic complications was 10.7% (23 of 215 patients). Univariate analysis showed that male gender, body mass index higher than 25 kg/m(2), smoking history, smoking amount, type of operation, and presence of a protective stoma were associated with anastomotic complications. In multivariate analysis, a history of heavy smoking was a significant risk factor for anastomotic complications. CONCLUSIONS: A history of heavy smoking (more than 40 pack-years) is an independently significant risk factor for anastomotic complications after low anterior resection in rectal cancerpatients.
Authors: Guillaume Martel; Youssuf Al-Suhaibani; Husein Moloo; Fatima Haggar; Martin Friedlich; Joseph Mamazza; Eric C Poulin; Hartley Stern; Robin P Boushey Journal: Dis Colon Rectum Date: 2008-06-04 Impact factor: 4.585
Authors: Johannes Klose; Ignazio Tarantino; Armin von Fournier; Moritz J Stowitzki; Yakup Kulu; Thomas Bruckner; Claudia Volz; Thomas Schmidt; Martin Schneider; Markus W Büchler; Alexis Ulrich Journal: J Gastrointest Surg Date: 2018-05-18 Impact factor: 3.452
Authors: A Arezzo; M Migliore; P Chiaro; S Arolfo; C Filippini; D Di Cuonzo; R Cirocchi; M Morino Journal: Tech Coloproctol Date: 2019-06-25 Impact factor: 3.781
Authors: Jeonghyun Kang; Han Beom Lee; Jang Ho Cha; Hyuk Hur; Byung Soh Min; Seung Hyuk Baik; Nam Kyu Kim; Seung Kook Sohn; Kang Young Lee Journal: J Gastrointest Surg Date: 2013-01-04 Impact factor: 3.452