BACKGROUND: Only a few studies have used in/opposed phase method for a quantitative evaluation of fat fraction in the spine. PURPOSE: To compare multivoxel proton MR spectroscopy and chemical-shift gradient-echo MR imaging for bone marrow fat quantification in vertebral compression fractures (VCF). MATERIAL AND METHODS: Vertebral marrow fat quantification in fifteen patients was measured at 3.0-T. Multi-voxel proton spectroscopy (MRS) and in/opposed-phase MR imaging using a fat map build with a triple-echo gradient-echo sequence was used. All the patients had benign vertebral collapse. Bone marrow fat content was evaluated by both techniques in compressed (acute or chronic) and in non-compressed vertebrae. RESULTS: The percentage of fat fraction measured by the triple-echo sequence was well correlated with those calculated by MRS (r(2) = 0.85; P < 10(-4)). There was a significant decrease of fat fraction in acute VCF versus both chronic VCF (P < 10(-9)) and non-fractured vertebrae (P < 10(-7)). There was no significant difference in fat fraction evaluated by both techniques between non-fractured vertebrae and chronic VCF. CONCLUSION: We have validated the in/opposed phase method compared with MRS for vertebral bone marrow fat quantification. The fat mapping using a triple-echo gradient-echo sequence allows distinguishing acute and chronic benign VCF.
BACKGROUND: Only a few studies have used in/opposed phase method for a quantitative evaluation of fat fraction in the spine. PURPOSE: To compare multivoxel proton MR spectroscopy and chemical-shift gradient-echo MR imaging for bone marrow fat quantification in vertebral compression fractures (VCF). MATERIAL AND METHODS: Vertebral marrow fat quantification in fifteen patients was measured at 3.0-T. Multi-voxel proton spectroscopy (MRS) and in/opposed-phase MR imaging using a fat map build with a triple-echo gradient-echo sequence was used. All the patients had benign vertebral collapse. Bone marrow fat content was evaluated by both techniques in compressed (acute or chronic) and in non-compressed vertebrae. RESULTS: The percentage of fat fraction measured by the triple-echo sequence was well correlated with those calculated by MRS (r(2) = 0.85; P < 10(-4)). There was a significant decrease of fat fraction in acute VCF versus both chronic VCF (P < 10(-9)) and non-fractured vertebrae (P < 10(-7)). There was no significant difference in fat fraction evaluated by both techniques between non-fractured vertebrae and chronic VCF. CONCLUSION: We have validated the in/opposed phase method compared with MRS for vertebral bone marrow fat quantification. The fat mapping using a triple-echo gradient-echo sequence allows distinguishing acute and chronic benign VCF.
Authors: X Ojanen; R J H Borra; M Havu; S M Cheng; R Parkkola; P Nuutila; M Alen; S Cheng Journal: Osteoporos Int Date: 2013-08-14 Impact factor: 4.507
Authors: Erica L Scheller; Nancy Troiano; Joshua N Vanhoutan; Mary A Bouxsein; Jackie A Fretz; Yougen Xi; Tracy Nelson; Griffin Katz; Ryan Berry; Christopher D Church; Casey R Doucette; Matthew S Rodeheffer; Ormond A Macdougald; Clifford J Rosen; Mark C Horowitz Journal: Methods Enzymol Date: 2014 Impact factor: 1.600
Authors: Fahad H Abduljabbar; Abdulaziz Al-Jurayyan; Saad Alqahtani; Zeeshan M Sardar; Rajeet Singh Saluja; Jean Ouellet; Michael Weber; Thomas Steffen; Lorne Beckman; Peter Jarzem Journal: Global Spine J Date: 2015-02-26
Authors: Akash Swamy; Gustav Burström; Jarich W Spliethoff; Drazenko Babic; Christian Reich; Joanneke Groen; Erik Edström; Adrian Elmi Terander; John M Racadio; Jenny Dankelman; Benno H W Hendriks Journal: J Biomed Opt Date: 2019-01 Impact factor: 3.170