| Literature DB >> 21925312 |
Nidhi Bhutani1, David M Burns, Helen M Blau.
Abstract
The discovery of cytosine hydroxymethylation (5hmC) suggested a simple means of demethylating DNA and activating genes. Further experiments, however, unearthed an unexpectedly complex process, entailing both passive and active mechanisms of DNA demethylation by the ten-eleven translocation (TET) and AID/APOBEC families of enzymes. The consensus emerging from these studies is that removal of cytosine methylation in mammalian cells can occur by DNA repair. These reports highlight that in certain contexts, DNA methylation is not fixed but dynamic, requiring continuous regulation.Entities:
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Year: 2011 PMID： 21925312 PMCID： PMC3236603 DOI： 10.1016/j.cell.2011.08.042
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582