Literature DB >> 21896916

Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine.

Nahla B Gadalla1, Ishag Adam, Salah-Eldin Elzaki, Sahar Bashir, Izdihar Mukhtar, Mary Oguike, Amal Gadalla, Fathi Mansour, David Warhurst, Badria B El-Sayed, Colin J Sutherland.   

Abstract

Molecular markers for surveillance of Plasmodium falciparum resistance to current antimalarials are sorely needed. A 28-day efficacy study of artemether-lumefantrine in eastern Sudan identified 5 treatment failures among 100 evaluable patients; 9 further individuals were parasite positive by PCR during follow-up. Polymorphisms in pfatpase6 and pfmdr1 were evaluated by DNA sequencing. One individual carried parasites with a novel pfmdr1 polymorphism (F1044L). pfmdr1 gene amplification in parasites prior to treatment occurred in three individuals who had recurrent infection during follow-up.

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Year:  2011        PMID： 21896916      PMCID： PMC3195064          DOI： 10.1128/AAC.05102-11

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  35 in total

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Journal:  J Infect Dis       Date:  2010-05-15       Impact factor: 5.226

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Journal:  Antimicrob Agents Chemother       Date:  2010-04-26       Impact factor: 5.191

5.  Descriptive study on the efficacy of artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Sudan.

Authors:  Sakina Babikir Elamin; Abdelmoneim Ismail Awad; Idris Babiker Eltayeb; Khalid Abdelmutalab Elmardi; Asma Hashim Al Hassan; AbedlRahim Osman Mohamed; Elfatih Mohammad Malik; Tarig Abedelgadir Mohamad
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6.  Investigations into the role of the Plasmodium falciparum SERCA (PfATP6) L263E mutation in artemisinin action and resistance.

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Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
Journal:  N Engl J Med       Date:  2009-07-30       Impact factor: 91.245

10.  Self-reported fever, treatment actions and malaria infection prevalence in the northern states of Sudan.

Authors:  Khalid A Elmardi; Abdisalan M Noor; Sophie Githinji; Tareg M Abdelgadir; Elfatih M Malik; Robert W Snow
Journal:  Malar J       Date:  2011-05-15       Impact factor: 2.979
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  41 in total

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Journal:  Mol Microbiol       Date:  2012-08-06       Impact factor: 3.501

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Journal:  Antimicrob Agents Chemother       Date:  2016-12-27       Impact factor: 5.191

3.  Molecular surveillance as monitoring tool for drug-resistant Plasmodium falciparum in Suriname.

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Authors:  Edwin Ochong; Patrick K Tumwebaze; Oswald Byaruhanga; Bryan Greenhouse; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2013-06-24       Impact factor: 5.191

6.  Plasmodium falciparum Polymorphisms associated with ex vivo drug susceptibility and clinical effectiveness of artemisinin-based combination therapies in Benin.

Authors:  Sabina Dahlström; Agnès Aubouy; Oumou Maïga-Ascofaré; Jean-François Faucher; Abel Wakpo; Sèm Ezinmègnon; Achille Massougbodji; Pascal Houzé; Eric Kendjo; Philippe Deloron; Jacques Le Bras; Sandrine Houzé
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7.  Molecular Detection of Residual Parasitemia after Pyronaridine-Artesunate or Artemether-Lumefantrine Treatment of Uncomplicated Plasmodium falciparum Malaria in Kenyan Children.

Authors:  Johanna M Roth; Patrick Sawa; George Omweri; Nicodemus Makio; Victor Osoti; Menno D de Jong; Henk D F H Schallig; Pètra F Mens
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8.  Various pfcrt and pfmdr1 genotypes of Plasmodium falciparum cocirculate with P. malariae, P. ovale spp., and P. vivax in northern Angola.

Authors:  Cláudia Fançony; Dina Gamboa; Yuri Sebastião; Rachel Hallett; Colin Sutherland; José Carlos Sousa-Figueiredo; Susana Vaz Nery
Journal:  Antimicrob Agents Chemother       Date:  2012-07-30       Impact factor: 5.191

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10.  Persistent Submicroscopic Plasmodium falciparum Parasitemia 72 Hours after Treatment with Artemether-Lumefantrine Predicts 42-Day Treatment Failure in Mali and Burkina Faso.

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Journal:  Antimicrob Agents Chemother       Date:  2021-07-16       Impact factor: 5.191
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