Literature DB >> 20668121

pfmdr1 amplification associated with clinical resistance to mefloquine in West Africa: implications for efficacy of artemisinin combination therapies.

Benoit Witkowski1, Xavier Iriart, Patrice Njomnang Soh, Sandie Menard, Muriel Alvarez, Veronique Naneix-Laroche, Bruno Marchou, Jean-François Magnaval, Françoise Benoit-Vical, Antoine Berry.   

Abstract

We describe here a clinical failure in the treatment with mefloquine of acute falciparum malaria contracted in Africa and associated with in vitro mefloquine resistance and pfmdr1 copy number amplification. This case raises the question of the presence and the evolution of this genotype in Africa, which is also known to alter the susceptibility to artemisinin combination therapy (ACT).

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Year:  2010        PMID： 20668121      PMCID： PMC2953132          DOI： 10.1128/JCM.01057-10

Source DB:  PubMed          Journal:  J Clin Microbiol        ISSN： 0095-1137            Impact factor:   5.948


  25 in total

1.  Amplification of Plasmodium falciparum multidrug resistance gene 1 in isolates from Gabon.

Authors:  Anne-Catrin Uhlemann; Michael Ramharter; Bertrand Lell; Peter G Kremsner; Sanjeev Krishna
Journal:  J Infect Dis       Date:  2005-10-07       Impact factor: 5.226

2.  Amodiaquine resistance is not related to rare findings of pfmdr1 gene amplifications in Kenya.

Authors:  Gabrielle Holmgren; Anders Björkman; José Pedro Gil
Journal:  Trop Med Int Health       Date:  2006-12       Impact factor: 2.622

3.  pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparum.

Authors:  Amar Bir Singh Sidhu; Stephanie Gaw Valderramos; David A Fidock
Journal:  Mol Microbiol       Date:  2005-08       Impact factor: 3.501

4.  Trioxaquines are new antimalarial agents active on all erythrocytic forms, including gametocytes.

Authors:  Françoise Benoit-Vical; Joël Lelièvre; Antoine Berry; Caroline Deymier; Odile Dechy-Cabaret; Jérôme Cazelles; Christophe Loup; Anne Robert; Jean-François Magnaval; Bernard Meunier
Journal:  Antimicrob Agents Chemother       Date:  2007-01-22       Impact factor: 5.191

5.  Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand.

Authors:  Anne-Catrin Uhlemann; Rose McGready; Elizabeth A Ashley; Alan Brockman; Pratap Singhasivanon; Sanjeev Krishna; Nicholas J White; Francois Nosten; Ric N Price
Journal:  J Infect Dis       Date:  2006-11-21       Impact factor: 5.226

6.  Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malaria.

Authors:  Ric N Price; Anne-Catrin Uhlemann; Michele van Vugt; Al Brockman; Robert Hutagalung; Shalini Nair; Denae Nash; Pratap Singhasivanon; Tim J C Anderson; Sanjeev Krishna; Nicholas J White; François Nosten
Journal:  Clin Infect Dis       Date:  2006-04-26       Impact factor: 9.079

7.  Plasmodium falciparum pfmdr1 amplification, mefloquine resistance, and parasite fitness.

Authors:  Piyanuch Preechapornkul; Mallika Imwong; Kesinee Chotivanich; Wirichada Pongtavornpinyo; Arjen M Dondorp; Nicholas P J Day; Nicholas J White; Sasithon Pukrittayakamee
Journal:  Antimicrob Agents Chemother       Date:  2009-01-21       Impact factor: 5.191

8.  Pfmdr1 copy number and arteminisin derivatives combination therapy failure in falciparum malaria in Cambodia.

Authors:  Pharath Lim; Alisa P Alker; Nimol Khim; Naman K Shah; Sandra Incardona; Socheat Doung; Poravuth Yi; Denis Mey Bouth; Christiane Bouchier; Odile Mercereau Puijalon; Steven R Meshnick; Chansuda Wongsrichanalai; Thierry Fandeur; Jacques Le Bras; Pascal Ringwald; Frédéric Ariey
Journal:  Malar J       Date:  2009-01-12       Impact factor: 2.979

9.  Changes in the treatment responses to artesunate-mefloquine on the northwestern border of Thailand during 13 years of continuous deployment.

Authors:  Verena Ilona Carrara; Julien Zwang; Elizabeth A Ashley; Ric N Price; Kasia Stepniewska; Marion Barends; Alan Brockman; Tim Anderson; Rose McGready; Lucy Phaiphun; Stephane Proux; Michele van Vugt; Robert Hutagalung; Khin Maung Lwin; Aung Pyae Phyo; Piyanuch Preechapornkul; Mallika Imwong; Sasithon Pukrittayakamee; Pratap Singhasivanon; Nicholas J White; François Nosten
Journal:  PLoS One       Date:  2009-02-23       Impact factor: 3.240

10.  Antimalarial drug prescribing practice in private and public health facilities in South-east Nigeria: a descriptive study.

Authors:  Martin Meremikwu; Uduak Okomo; Chukwuemeka Nwachukwu; Angela Oyo-Ita; John Eke-Njoku; Joseph Okebe; Esu Oyo-Ita; Paul Garner
Journal:  Malar J       Date:  2007-05-04       Impact factor: 2.979
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  11 in total

1.  Limited ability of Plasmodium falciparum pfcrt, pfmdr1, and pfnhe1 polymorphisms to predict quinine in vitro sensitivity or clinical effectiveness in Uganda.

Authors:  Frederick N Baliraine; Samuel L Nsobya; Jane Achan; James K Tibenderana; Ambrose O Talisuna; Bryan Greenhouse; Philip J Rosenthal
Journal:  Antimicrob Agents Chemother       Date:  2010-11-15       Impact factor: 5.191

2.  Increased pfmdr1 copy number and sequence polymorphisms in Plasmodium falciparum isolates from Sudanese malaria patients treated with artemether-lumefantrine.

Authors:  Nahla B Gadalla; Ishag Adam; Salah-Eldin Elzaki; Sahar Bashir; Izdihar Mukhtar; Mary Oguike; Amal Gadalla; Fathi Mansour; David Warhurst; Badria B El-Sayed; Colin J Sutherland
Journal:  Antimicrob Agents Chemother       Date:  2011-09-06       Impact factor: 5.191

3.  A malaria gametocytocidal assay using oxidoreduction indicator, alamarBlue.

Authors:  Takeshi Q Tanaka; Kim C Williamson
Journal:  Mol Biochem Parasitol       Date:  2011-02-18       Impact factor: 1.759

4.  Polymorphisms of molecular markers of antimalarial drug resistance and relationship with artesunate-mefloquine combination therapy in patients with uncomplicated Plasmodium falciparum malaria in Thailand.

Authors:  Poonuch Muhamad; Papichaya Phompradit; Wannapa Sornjai; Thunyaluk Maensathian; Wanna Chaijaroenkul; Ronnatrai Rueangweerayut; Kesara Na-Bangchang
Journal:  Am J Trop Med Hyg       Date:  2011-09       Impact factor: 2.345

5.  Polymorphic patterns of pfcrt and pfmdr1 in Plasmodium falciparum isolates along the Thai-Myanmar border.

Authors:  Phunuch Muhamad; Wanna Chaijaroenkul; Papichaya Phompradit; Ronnatrai Rueangweerayut; Pongsri Tippawangkosol; Kesara Na-Bangchang
Journal:  Asian Pac J Trop Biomed       Date:  2013-12

6.  A quantitative high throughput assay for identifying gametocytocidal compounds.

Authors:  Takeshi Q Tanaka; Seameen J Dehdashti; Dac-Trung Nguyen; John C McKew; Wei Zheng; Kim C Williamson
Journal:  Mol Biochem Parasitol       Date:  2013-02-27       Impact factor: 1.759

7.  Prevalence of molecular markers of Plasmodium falciparum drug resistance in Dakar, Senegal.

Authors:  Nathalie Wurtz; Bécaye Fall; Aurélie Pascual; Silmane Diawara; Kowry Sow; Eric Baret; Bakary Diatta; Khadidiatou B Fall; Pape S Mbaye; Fatou Fall; Yaya Diémé; Christophe Rogier; Raymond Bercion; Sébastien Briolant; Boubacar Wade; Bruno Pradines
Journal:  Malar J       Date:  2012-06-13       Impact factor: 2.979

8.  Increased pfmdr1 gene copy number and the decline in pfcrt and pfmdr1 resistance alleles in Ghanaian Plasmodium falciparum isolates after the change of anti-malarial drug treatment policy.

Authors:  Nancy O Duah; Sena A Matrevi; Dziedzom K de Souza; Daniel D Binnah; Mary M Tamakloe; Vera S Opoku; Christiana O Onwona; Charles A Narh; Neils B Quashie; Benjamin Abuaku; Christopher Duplessis; Karl C Kronmann; Kwadwo A Koram
Journal:  Malar J       Date:  2013-10-30       Impact factor: 2.979

9.  Analysis of major genome loci underlying artemisinin resistance and pfmdr1 copy number in pre- and post-ACTs in western Kenya.

Authors:  Bidii S Ngalah; Luiser A Ingasia; Agnes C Cheruiyot; Lorna J Chebon; Dennis W Juma; Peninah Muiruri; Irene Onyango; Jack Ogony; Redemptah A Yeda; Jelagat Cheruiyot; Emmanuel Mbuba; Grace Mwangoka; Angela O Achieng; Zipporah Ng'ang'a; Ben Andagalu; Hoseah M Akala; Edwin Kamau
Journal:  Sci Rep       Date:  2015-02-06       Impact factor: 4.379

10.  Plasmodium falciparum with multidrug resistance 1 gene duplications, Senegal.

Authors:  Aurélie Pascual; Bécaye Fall; Nathalie Wurtz; Mansour Fall; Cheikhou Camara; Aminata Nakoulima; Eric Baret; Bakary Diatta; Boubacar Wade; Sébastien Briolant; Bruno Pradines
Journal:  Emerg Infect Dis       Date:  2013-05       Impact factor: 6.883
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