Literature DB >> 23836177

The polymorphic linker domain of pfmdr1 is associated with resistance-conferring mutations in Plasmodium falciparum populations from East and West Africa.

John Okombo1, Issaka Zongo, Nahla Gadalla, Teun Bousema, Khalid B Beshir, Cally Roper, Rachel Hallett, Lynette Isabella Ochola-Oyier, Colin J Sutherland.   

Abstract

Sequence variation in the asparagine/aspartate-rich domain of pfmdr1 in 215 isolates of Plasmodium falciparum from three African countries was compared with published data. The role of this domain in modulating antimalarial sensitivity has not been established. The pfmdr1 86Y allele was significantly associated with different configurations of the Asn/Asp-rich domain in West and East Africa. In Kenya, a specific form of the Asn/Asp-rich domain was significantly linked to the 86Y, 184Y, and 1246Y haplotype of pfmdr1.

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Year:  2013        PMID： 23836177      PMCID： PMC3754354          DOI： 10.1128/AAC.00455-13

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

1.  Evidence of artemisinin-resistant malaria in western Cambodia.

Authors:  Harald Noedl; Youry Se; Kurt Schaecher; Bryan L Smith; Duong Socheat; Mark M Fukuda
Journal:  N Engl J Med       Date:  2008-12-08       Impact factor: 91.245

2.  The linker region of the ABC-transporter Ste6 mediates ubiquitination and fast turnover of the protein.

Authors:  R Kölling; S Losko
Journal:  EMBO J       Date:  1997-05-01       Impact factor: 11.598

3.  The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisinin.

Authors:  M T Duraisingh; P Jones; I Sambou; L von Seidlein; M Pinder; D C Warhurst
Journal:  Mol Biochem Parasitol       Date:  2000-04-30       Impact factor: 1.759

4.  Asparagine repeat function in a Plasmodium falciparum protein assessed via a regulatable fluorescent affinity tag.

Authors:  Vasant Muralidharan; Anna Oksman; Mari Iwamoto; Thomas J Wandless; Daniel E Goldberg
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-28       Impact factor: 11.205

5.  Artesunate tolerance in transgenic Plasmodium falciparum parasites overexpressing a tryptophan-rich protein.

Authors:  Guillaume Deplaine; Catherine Lavazec; Emmanuel Bischoff; Onguma Natalang; Sylvie Perrot; Micheline Guillotte-Blisnick; Jean-Yves Coppée; Bruno Pradines; Odile Mercereau-Puijalon; Peter H David
Journal:  Antimicrob Agents Chemother       Date:  2011-04-04       Impact factor: 5.191

6.  Artemisinin resistance in Plasmodium falciparum malaria.

Authors:  Arjen M Dondorp; François Nosten; Poravuth Yi; Debashish Das; Aung Phae Phyo; Joel Tarning; Khin Maung Lwin; Frederic Ariey; Warunee Hanpithakpong; Sue J Lee; Pascal Ringwald; Kamolrat Silamut; Mallika Imwong; Kesinee Chotivanich; Pharath Lim; Trent Herdman; Sen Sam An; Shunmay Yeung; Pratap Singhasivanon; Nicholas P J Day; Niklas Lindegardh; Duong Socheat; Nicholas J White
Journal:  N Engl J Med       Date:  2009-07-30       Impact factor: 91.245

7.  Amplification of pfmdr 1 associated with mefloquine and halofantrine resistance in Plasmodium falciparum from Thailand.

Authors:  C M Wilson; S K Volkman; S Thaithong; R K Martin; D E Kyle; W K Milhous; D F Wirth
Journal:  Mol Biochem Parasitol       Date:  1993-01       Impact factor: 1.759

8.  Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast.

Authors:  Steffen Borrmann; Philip Sasi; Leah Mwai; Mahfudh Bashraheil; Ahmed Abdallah; Steven Muriithi; Henrike Frühauf; Barbara Schaub; Johannes Pfeil; Judy Peshu; Warunee Hanpithakpong; Anja Rippert; Elizabeth Juma; Benjamin Tsofa; Moses Mosobo; Brett Lowe; Faith Osier; Greg Fegan; Niklas Lindegårdh; Alexis Nzila; Norbert Peshu; Margaret Mackinnon; Kevin Marsh
Journal:  PLoS One       Date:  2011-11-10       Impact factor: 3.240

9.  Gametocytaemia after drug treatment of asymptomatic Plasmodium falciparum.

Authors:  Samuel Dunyo; Paul Milligan; Tansy Edwards; Colin Sutherland; Geoffrey Targett; Margaret Pinder
Journal:  PLoS Clin Trials       Date:  2006-08-18

10.  Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.

Authors:  Paul Hunt; Ana Afonso; Alison Creasey; Richard Culleton; Amar Bir Singh Sidhu; John Logan; Stephanie G Valderramos; Iain McNae; Sandra Cheesman; Virgilio do Rosario; Richard Carter; David A Fidock; Pedro Cravo
Journal:  Mol Microbiol       Date:  2007-07       Impact factor: 3.501
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  3 in total

1.  Repeat polymorphisms in the low-complexity regions of Plasmodium falciparum ABC transporters and associations with in vitro antimalarial responses.

Authors:  John Okombo; Abdirahman I Abdi; Steven M Kiara; Leah Mwai; Lewa Pole; Colin J Sutherland; Alexis Nzila; Lynette Isabella Ochola-Oyier
Journal:  Antimicrob Agents Chemother       Date:  2013-09-30       Impact factor: 5.191

2.  Mutations in Plasmodium falciparum actin-binding protein coronin confer reduced artemisinin susceptibility.

Authors:  Allison R Demas; Aabha I Sharma; Wesley Wong; Angela M Early; Seth Redmond; Selina Bopp; Daniel E Neafsey; Sarah K Volkman; Daniel L Hartl; Dyann F Wirth
Journal:  Proc Natl Acad Sci U S A       Date:  2018-11-12       Impact factor: 11.205

3.  No evidence of P. falciparum K13 artemisinin conferring mutations over a 24-year analysis in Coastal Kenya, but a near complete reversion to chloroquine wild type parasites.

Authors:  Kevin Wamae; Dorcas Okanda; Leonard Ndwiga; Victor Osoti; Kelvin M Kimenyi; Abdirahman I Abdi; Philip Bejon; Colin Sutherland; Lynette Isabella Ochola-Oyier
Journal:  Antimicrob Agents Chemother       Date:  2019-10-07       Impact factor: 5.191
  3 in total

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