Literature DB >> 21893416

Design and synthesis of inhibitors of noroviruses by scaffold hopping.

Dengfeng Dou1, Sivakoteswara Rao Mandadapu, Kevin R Alliston, Yunjeong Kim, Kyeong-Ok Chang, William C Groutas.   

Abstract

A scaffold hopping strategy was employed to identify new chemotypes that inhibit noroviruses. The replacement of the cyclosulfamide scaffold by an array of heterocyclic scaffolds lead to the identification of additional series of compounds that possessed anti-norovirus activity in a cell-based replicon system.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21893416      PMCID： PMC3199213          DOI： 10.1016/j.bmc.2011.08.032

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  19 in total

1.  Targeting norovirus infection-multivalent entry inhibitor design based on NMR experiments.

Authors:  Christoph Rademacher; Julie Guiard; Pavel I Kitov; Brigitte Fiege; Kevin P Dalton; Francisco Parra; David R Bundle; Thomas Peters
Journal:  Chemistry       Date:  2011-05-12       Impact factor: 5.236

2.  Structure-based design of a general class of mechanism-based inhibitors of the serine proteinases employing a novel amino acid-derived heterocyclic scaffold.

Authors:  W C Groutas; R Kuang; R Venkataraman; J B Epp; S Ruan; O Prakash
Journal:  Biochemistry       Date:  1997-04-22       Impact factor: 3.162

3.  Stable expression of a Norwalk virus RNA replicon in a human hepatoma cell line.

Authors:  Kyeong-Ok Chang; Stanislav V Sosnovtsev; Gaël Belliot; Adriene D King; Kim Y Green
Journal:  Virology       Date:  2006-07-14       Impact factor: 3.616

4.  Role of cholesterol pathways in norovirus replication.

Authors:  Kyeong-Ok Chang
Journal:  J Virol       Date:  2009-06-10       Impact factor: 5.103

5.  Synthesis of triazole-oxazolidinones via a one-pot reaction and evaluation of their antimicrobial activity.

Authors:  Jeffrey A Demaray; Jason E Thuener; Matthew N Dawson; Steven J Sucheck
Journal:  Bioorg Med Chem Lett       Date:  2008-07-24       Impact factor: 2.823

6.  Potent inhibition of human leukocyte elastase by 1,2,5-thiadiazolidin-3-one 1,1 dioxide-based sulfonamide derivatives.

Authors:  Zhong Lai; Xiangdong Gan; Liuqing Wei; Kevin R Alliston; Hongyi Yu; Yue H Li; William C Groutas
Journal:  Arch Biochem Biophys       Date:  2004-09-15       Impact factor: 4.013

7.  Some benzyl-substituted imidazoles, triazoles, tetrazoles, pyridinethiones, and structural relatives as multisubstrate inhibitors of dopamine beta-hydroxylase. 4. Structure-activity relationships at the copper binding site.

Authors:  L I Kruse; C Kaiser; W E DeWolf; J A Finkelstein; J S Frazee; E L Hilbert; S T Ross; K E Flaim; J L Sawyer
Journal:  J Med Chem       Date:  1990-02       Impact factor: 7.446

8.  Interferons and ribavirin effectively inhibit Norwalk virus replication in replicon-bearing cells.

Authors:  Kyeong-Ok Chang; David W George
Journal:  J Virol       Date:  2007-09-12       Impact factor: 5.103

Review 9.  Norovirus gastroenteritis, increased understanding and future antiviral options.

Authors:  Ming Tan; Xi Jiang
Journal:  Curr Opin Investig Drugs       Date:  2008-02

10.  Histone deacetylase inhibitors through click chemistry.

Authors:  Jie Shen; Robert Woodward; James Patrick Kedenburg; Xianwei Liu; Min Chen; Lanyan Fang; Duxin Sun; Peng George Wang
Journal:  J Med Chem       Date:  2008-12-11       Impact factor: 7.446
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  15 in total

1.  Cyclosulfamide-based derivatives as inhibitors of noroviruses.

Authors:  Dengfeng Dou; Sivakoteswara R Mandadapu; Kevin R Alliston; Yunjeong Kim; Kyeong-Ok Chang; William C Groutas
Journal:  Eur J Med Chem       Date:  2011-10-20       Impact factor: 6.514

2.  Structural and inhibitor studies of norovirus 3C-like proteases.

Authors:  Daisuke Takahashi; Yunjeong Kim; Scott Lovell; Om Prakash; William C Groutas; Kyeong-Ok Chang
Journal:  Virus Res       Date:  2013-09-17       Impact factor: 3.303

3.  Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics.

Authors:  Sivakoteswara Rao Mandadapu; Mallikarjuna Reddy Gunnam; Anushka C Galasiti Kankanamalage; Roxanne Adeline Z Uy; Kevin R Alliston; Gerald H Lushington; Yunjeong Kim; Kyeong-Ok Chang; William C Groutas
Journal:  Bioorg Med Chem Lett       Date:  2013-08-22       Impact factor: 2.823

4.  Inhibition of noroviruses by piperazine derivatives.

Authors:  Dengfeng Dou; Guijia He; Sivakoteswara Rao Mandadapu; Sridhar Aravapalli; Yunjeong Kim; Kyeong-Ok Chang; William C Groutas
Journal:  Bioorg Med Chem Lett       Date:  2011-11-15       Impact factor: 2.823

5.  Identification of RNA-protein interaction networks involved in the norovirus life cycle.

Authors:  Surender Vashist; Luis Urena; Yasmin Chaudhry; Ian Goodfellow
Journal:  J Virol       Date:  2012-08-29       Impact factor: 5.103

Review 6.  Treatment of norovirus infections: moving antivirals from the bench to the bedside.

Authors:  Stuart S Kaufman; Kim Y Green; Brent E Korba
Journal:  Antiviral Res       Date:  2014-02-25       Impact factor: 5.970

7.  Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies.

Authors:  Anushka C Galasiti Kankanamalage; Yunjeong Kim; Pathum M Weerawarna; Roxanne Adeline Z Uy; Vishnu C Damalanka; Sivakoteswara Rao Mandadapu; Kevin R Alliston; Nurjahan Mehzabeen; Kevin P Battaile; Scott Lovell; Kyeong-Ok Chang; William C Groutas
Journal:  J Med Chem       Date:  2015-03-19       Impact factor: 7.446

Review 8.  Recent Advances in the Discovery of Norovirus Therapeutics.

Authors:  Yunjeong Kim; Anushka C Galasiti Kankanamalage; Kyeong-Ok Chang; William C Groutas
Journal:  J Med Chem       Date:  2015-08-17       Impact factor: 7.446

9.  Inhibition of norovirus 3CL protease by bisulfite adducts of transition state inhibitors.

Authors:  Sivakoteswara Rao Mandadapu; Mallikarjuna Reddy Gunnam; Kok-Chuan Tiew; Roxanne Adeline Z Uy; Allan M Prior; Kevin R Alliston; Duy H Hua; Yunjeong Kim; Kyeong-Ok Chang; William C Groutas
Journal:  Bioorg Med Chem Lett       Date:  2012-11-21       Impact factor: 2.823

Review 10.  Anti-norovirus therapeutics: a patent review (2010-2015).

Authors:  Anushka C Galasiti Kankanamalage; Pathum M Weerawarna; Yunjeong Kim; Kyeong-Ok Chang; William C Groutas
Journal:  Expert Opin Ther Pat       Date:  2016       Impact factor: 6.674
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