Literature DB >> 18678487

Synthesis of triazole-oxazolidinones via a one-pot reaction and evaluation of their antimicrobial activity.

Jeffrey A Demaray1, Jason E Thuener, Matthew N Dawson, Steven J Sucheck.   

Abstract

C-5-substituted triazole-oxazolidinones were synthesized using a bromide catalyzed cycloaddition between aryl isocyanates and epibromohydrin followed by a three-component Huisgen cycloaddition. The library of compounds was screened for antibacterial activity against Mycobacterium smegmatis ATCC 14468, Bacillus subtilis ATCC 6633, and Enterococcus faecalis ATCC 29212. Notably, the 3-(4-acetyl-phenyl)-5-(1H-1,2,3-triazol-1-yl)methyl)-oxazolidin-2-one (18) showed an MIC of 1 microg/mL against M. smegmatis ATCC 14468, fourfold lower than the MIC measured for isoniazid.

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Year:  2008        PMID： 18678487     DOI： 10.1016/j.bmcl.2008.07.087

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

1.  Design and synthesis of inhibitors of noroviruses by scaffold hopping.

Authors:  Dengfeng Dou; Sivakoteswara Rao Mandadapu; Kevin R Alliston; Yunjeong Kim; Kyeong-Ok Chang; William C Groutas
Journal:  Bioorg Med Chem       Date:  2011-08-22       Impact factor: 3.641

2.  Design and synthesis of 3,3'-triazolyl biisoquinoline N,N'-dioxides via Hiyama cross-coupling of 4-trimethylsilyl-1,2,3-triazoles.

Authors:  Shiyu Sun; Carlyn Reep; Chenrui Zhang; Burjor Captain; Roberto Peverati; Norito Takenaka
Journal:  Tetrahedron Lett       Date:  2021-08-21       Impact factor: 2.032

3.  Synthesis and antifungal activity of novel oxazolidin-2-one-linked 1,2,3-triazole derivatives.

Authors:  Alejandra Ramírez-Villalva; Davir González-Calderón; Roxana I Rojas-García; Carlos González-Romero; Joaquín Tamaríz-Mascarúa; Macario Morales-Rodríguez; Nieves Zavala-Segovia; Aydeé Fuentes-Benítes
Journal:  Medchemcomm       Date:  2017-10-17       Impact factor: 3.597

4.  Crystal structure analysis of [5-(4-meth-oxy-phen-yl)-2-methyl-2H-1,2,3-triazol-4-yl](thio-phen-2-yl)methanone.

Authors:  Subhrajyoti Bhandary; Yarabhally R Girish; Katharigatta N Venugopala; Deepak Chopra
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-07-31

Review 5.  Current updates on oxazolidinone and its significance.

Authors:  Neha Pandit; Rajeev K Singla; Birendra Shrivastava
Journal:  Int J Med Chem       Date:  2012-02-26

6.  Theoretical calculations of molecular descriptors for anticancer activities of 1, 2, 3-triazole-pyrimidine derivatives against gastric cancer cell line (MGC-803): DFT, QSAR and docking approaches.

Authors:  Rhoda Oyeladun Oyewole; Abel Kolawole Oyebamiji; Banjo Semire
Journal:  Heliyon       Date:  2020-05-21

7.  Novel Triazole Hybrids of Betulin: Synthesis and Biological Activity Profile.

Authors:  Ewa Bębenek; Maria Jastrzębska; Monika Kadela-Tomanek; Elwira Chrobak; Beata Orzechowska; Katarzyna Zwolińska; Małgorzata Latocha; Anna Mertas; Zenon Czuba; Stanisław Boryczka
Journal:  Molecules       Date:  2017-11-01       Impact factor: 4.411

8.  The synthesis, antiviral, cytostatic and cytotoxic evaluation of a new series of acyclonucleotide analogues with a 1,2,3-triazole linker.

Authors:  Iwona E Głowacka; Jan Balzarini; Andrzej E Wróblewski
Journal:  Eur J Med Chem       Date:  2013-10-30       Impact factor: 6.514
  8 in total

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