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Literature DB >> 24054123

Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics.

Sivakoteswara Rao Mandadapu¹, Mallikarjuna Reddy Gunnam, Anushka C Galasiti Kankanamalage, Roxanne Adeline Z Uy, Kevin R Alliston, Gerald H Lushington, Yunjeong Kim, Kyeong-Ok Chang, William C Groutas.

Abstract

The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity.

Entities: Chemical Disease Gene Species

Keywords: Inhibitors; Norovirus 3CL protease; Transition state mimics; α-Hydroxyphosphonates

Mesh：

Substances：

Year: 2013 PMID： 24054123 PMCID： PMC4916958 DOI： 10.1016/j.bmcl.2013.08.073

Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823

45 in total

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7. Potent norovirus inhibitors based on the acyclic sulfamide scaffold.

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8. alpha-Hydroxy phosphinyl-based inhibitors of human renin.

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9. Structure-based design and synthesis of triazole-based macrocyclic inhibitors of norovirus protease: Structural, biochemical, spectroscopic, and antiviral studies.

Authors: Pathum M Weerawarna; Yunjeong Kim; Anushka C Galasiti Kankanamalage; Vishnu C Damalanka; Gerald H Lushington; Kevin R Alliston; Nurjahan Mehzabeen; Kevin P Battaile; Scott Lovell; Kyeong-Ok Chang; William C Groutas
Journal: Eur J Med Chem Date: 2016-04-25 Impact factor: 6.514

Review 10. Therapeutics and Immunoprophylaxis Against Noroviruses and Rotaviruses: The Past, Present, and Future.

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Journal: Curr Drug Metab Date: 2018 Impact factor: 3.731