Literature DB >> 21891866

Is TNF a link between aging-related reproductive endocrine dyscrasia and Alzheimer's disease?

Ian A Clark1, Craig S Atwood.   

Abstract

This commentary addresses a novel mechanism by which aging-related changes in reproductive hormones could mediate their action in the brain. It presents the evidence that dyotic endocrine signals modulate the expression of tumor necrosis factor (TNF) and related cytokines, and that these cytokines are a functionally important downstream link mediating neurodegeneration and dysfunction. This convergence of dyotic signaling on TNF-mediated degeneration and dysfunction has important implications for understanding the pathophysiology of AD, stroke, and traumatic brain disease, and also for the treatment of these diseases.

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Year:  2011        PMID： 21891866      PMCID： PMC3753178          DOI： 10.3233/JAD-2011-110887

Source DB:  PubMed          Journal:  J Alzheimers Dis        ISSN： 1387-2877            Impact factor:   4.472


  125 in total

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Review 2.  Aberrancies in signal transduction and cell cycle related events in Alzheimer's disease.

Authors:  T Arendt; M Holzer; U Gärtner; M K Brückner
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Review 3.  The assessment of non-feminizing estrogens for use in neuroprotection.

Authors:  Kun Don Yi; Evelyn Perez; Shaohua Yang; Ran Liu; Douglas F Covey; James W Simpkins
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4.  Inhibitory effect of TNF alpha antibodies on synovial cell interleukin-1 production in rheumatoid arthritis.

Authors:  F M Brennan; D Chantry; A Jackson; R Maini; M Feldmann
Journal:  Lancet       Date:  1989-07-29       Impact factor: 79.321

5.  Inflammatory processes induce beta-amyloid precursor protein changes in mouse brain.

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6.  Cerebrospinal fluid oxytocin, life history of aggression, and personality disorder.

Authors:  Royce Lee; Craig Ferris; L D Van de Kar; Emil F Coccaro
Journal:  Psychoneuroendocrinology       Date:  2009-07-03       Impact factor: 4.905

Review 7.  TNF-alpha inhibition as a treatment strategy for neurodegenerative disorders: new drug candidates and targets.

Authors:  David Tweedie; Kumar Sambamurti; Nigel H Greig
Journal:  Curr Alzheimer Res       Date:  2007-09       Impact factor: 3.498

8.  Differential processing of amyloid-beta precursor protein directs human embryonic stem cell proliferation and differentiation into neuronal precursor cells.

Authors:  Prashob Porayette; Miguel J Gallego; Maria M Kaltcheva; Richard L Bowen; Sivan Vadakkadath Meethal; Craig S Atwood
Journal:  J Biol Chem       Date:  2009-06-19       Impact factor: 5.157

9.  Inhibitory effect of progesterone on inflammatory factors after experimental traumatic brain injury.

Authors:  De-Sheng Pan; Wei-Guo Liu; Xiao-Feng Yang; Fei Cao
Journal:  Biomed Environ Sci       Date:  2007-10       Impact factor: 3.118

10.  Social isolation alters neuroinflammatory response to stroke.

Authors:  Kate Karelina; Greg J Norman; Ning Zhang; John S Morris; Haiyan Peng; A Courtney DeVries
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  9 in total

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2.  Does the degree of endocrine dyscrasia post-reproduction dictate post-reproductive lifespan? Lessons from semelparous and iteroparous species.

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Journal:  Geroscience       Date:  2017-03-07       Impact factor: 7.713

3.  Changes of serum TNF-α, IL-5 and IgE levels in the patients of mycoplasma pneumonia infection with or without bronchial asthma.

Authors:  Lan Wang; Qiang Chen; Cuiqin Shi; Hanjing Lv; Xianghuai Xu; Li Yu
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Review 4.  Microglial priming in neurodegenerative disease.

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5.  Amyloid-β immunization enhances neurogenesis and cognitive ability in neonatal mice.

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Review 6.  The endocrine dyscrasia that accompanies menopause and andropause induces aberrant cell cycle signaling that triggers re-entry of post-mitotic neurons into the cell cycle, neurodysfunction, neurodegeneration and cognitive disease.

Authors:  Craig S Atwood; Richard L Bowen
Journal:  Horm Behav       Date:  2015-07-16       Impact factor: 3.587

Review 7.  A Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease Pathogenesis.

Authors:  Craig S Atwood; Richard L Bowen
Journal:  J Alzheimers Dis       Date:  2015       Impact factor: 4.472

8.  Induction of meiosis by embryonic gonadal somatic cells differentiated from pluripotent stem cells.

Authors:  Haiying Wang; Linlin Liu; Chang Liu; Lingling Wang; Jiyu Chen; Huasong Wang; Dai Heng; Ming Zeng; Chun Liu; Zhongcheng Zhou; Xiaoying Ye; Yajuan Wan; Huiyu Li; Lin Liu
Journal:  Stem Cell Res Ther       Date:  2021-12-20       Impact factor: 6.832

Review 9.  The Impact of Systemic Inflammation on Alzheimer's Disease Pathology.

Authors:  Junhua Xie; Lien Van Hoecke; Roosmarijn E Vandenbroucke
Journal:  Front Immunol       Date:  2022-01-06       Impact factor: 7.561
  9 in total

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