OBJECTIVE: This study aimed to investigate the changes of serum levels of TNF-α, IL-5 and IgE in mycoplasma pneumonia (MP) infection patients with or without bronchial asthma and explore its clinical importance. METHODS: ELISA and Western blot assay were performed to detect the serum levels of TNF-α, IL-5 and IgE in 35 healthy subjects, 45 patients with MP infection and 40 bronchial asthma patients with MP infection. RESULTS: The serum levels of TNF-α, IL-5 and IgE in MP infection patients and asthma patients with MP infection were significantly higher than those in healthy subjects (P<0.01). Moreover, the serum levels of TNF-α, IL-5 and IgE in asthma patients with MP infection was markedly higher than those in MP infection patients (P<0.05). Correlation analysis showed serum TNF-α was positively associated with serum IL-5 (r=0.9636, P<0.01), serum TNF-α positively related to IgE (r=0.9841, P<0.01) and serum IgE positively relevant with serum IL-5 (r=0.9572, P<0.01) in asthma patients with MP infection. CONCLUSION: Our findings indicate that serum levels of TNF-α, IL-5 and IgE may play important roles in the pathogenesis of MP infection, especially in asthma patients.
OBJECTIVE: This study aimed to investigate the changes of serum levels of TNF-α, IL-5 and IgE in mycoplasma pneumonia (MP) infectionpatients with or without bronchial asthma and explore its clinical importance. METHODS: ELISA and Western blot assay were performed to detect the serum levels of TNF-α, IL-5 and IgE in 35 healthy subjects, 45 patients with MP infection and 40 bronchial asthmapatients with MP infection. RESULTS: The serum levels of TNF-α, IL-5 and IgE in MP infectionpatients and asthmapatients with MP infection were significantly higher than those in healthy subjects (P<0.01). Moreover, the serum levels of TNF-α, IL-5 and IgE in asthmapatients with MP infection was markedly higher than those in MP infectionpatients (P<0.05). Correlation analysis showed serum TNF-α was positively associated with serum IL-5 (r=0.9636, P<0.01), serum TNF-α positively related to IgE (r=0.9841, P<0.01) and serum IgE positively relevant with serum IL-5 (r=0.9572, P<0.01) in asthmapatients with MP infection. CONCLUSION: Our findings indicate that serum levels of TNF-α, IL-5 and IgE may play important roles in the pathogenesis of MP infection, especially in asthmapatients.
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