| Literature DB >> 2569055 |
F M Brennan1, D Chantry, A Jackson, R Maini, M Feldmann.
Abstract
The effect of tumour necrosis factor (TNF alpha) antibodies on synovial cell interleukin-1 (IL-1) production was investigated in 7 patients with rheumatoid arthritis and in 7 with osteoarthritis. Synovial cell IL-1 production was significantly reduced by anti-TNF alpha antibody in cultures from patients with rheumatoid arthritis, but antilymphotoxin antibody did not have this effect (except in 1 culture). In cultures from patients with osteoarthritis spontaneous IL-1 production was low, despite high concentrations of TNF alpha, and IL-1 production was not inhibited by anti-TNF alpha antibody. In rheumatoid arthritis, TNF alpha may be the main inducer of IL-1, and anti-TNF alpha agents may be useful in treatment.Entities:
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Year: 1989 PMID： 2569055 DOI： 10.1016/s0140-6736(89)90430-3
Source DB: PubMed Journal: Lancet ISSN： 0140-6736 Impact factor: 79.321