Literature DB >> 3143353

Kinetic characterization of the acyl-enzyme mechanism for beta-lactamase I.

M T Martin1, S G Waley.   

Abstract

beta-Lactamase I catalyses the hydrolysis of penicillins by an acyl-enzyme mechanism. A procedure was developed for determining the rate constants for the acylation and deacylation steps for the good substrates benzylpenicillin and phenoxymethylpenicillin; this depends on determining the fraction of enzyme that is present as acyl-enzyme in the steady state.

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Year:  1988        PMID： 3143353      PMCID： PMC1135174          DOI： 10.1042/bj2540923

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  14 in total

1.  Diffusion-limited component of reactions catalyzed by Bacillus cereus beta-lactamase I.

Authors:  L W Hardy; J F Kirsch
Journal:  Biochemistry       Date:  1984-03       Impact factor: 3.162

2.  6 beta-Bromopenicillanic acid inactivates beta-lactamase I.

Authors:  V Knott-Hunziker; B S Orlek; P G Sammes; S G Waley
Journal:  Biochem J       Date:  1979-01-01       Impact factor: 3.857

3.  A spectrophotometric assay of beta-lactamase action on penicillins.

Authors:  S G Waley
Journal:  Biochem J       Date:  1974-06       Impact factor: 3.857

4.  Single-turnover and steady-state kinetics of hydrolysis of cephalosporins by beta-lactamase I from Bacillus cereus.

Authors:  R Bicknell; S G Waley
Journal:  Biochem J       Date:  1985-10-01       Impact factor: 3.857

5.  A direct spectrophotometric assay and determination of Michaelis constants for the beta-lactamase reaction.

Authors:  A Samuni
Journal:  Anal Biochem       Date:  1975-01       Impact factor: 3.365

6.  Production of a variant of beta-lactamase II with selectively decreased cephalosporinase activity by a mutant of Bacillus cereus 569/H/9.

Authors:  G S Baldwin; G F Edwards; P A Kiener; M J Tully; S G Waley; E P Abraham
Journal:  Biochem J       Date:  1980-10-01       Impact factor: 3.857

7.  Direct determination of acetyl-enzyme intermediate in the acetylcholinesterase-catalyzed hydrolysis of acetylcholine and acetylthiocholine.

Authors:  H C Froede; I B Wilson
Journal:  J Biol Chem       Date:  1984-09-10       Impact factor: 5.157

8.  Tertiary structural similarity between a class A beta-lactamase and a penicillin-sensitive D-alanyl carboxypeptidase-transpeptidase.

Authors:  B Samraoui; B J Sutton; R J Todd; P J Artymiuk; S G Waley; D C Phillips
Journal:  Nature       Date:  1986 Mar 27-Apr 2       Impact factor: 49.962

9.  Separation, purification and properties of beta-lactamase I and beta-lactamase II from Bacillus cereus 569/H/9.

Authors:  R B Davies; E P Abraham
Journal:  Biochem J       Date:  1974-10       Impact factor: 3.857

10.  The preparation and some properties of penicillenic acid derivatives relevant to penicillin hypersensitivity.

Authors:  C W PARKER; A L DEWECK; M KERN; H N EISEN
Journal:  J Exp Med       Date:  1962-04-01       Impact factor: 14.307
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  10 in total

1.  The bimodular G57-V577 polypeptide chain of the class B penicillin-binding protein 3 of Escherichia coli catalyzes peptide bond formation from thiolesters and does not catalyze glycan chain polymerization from the lipid II intermediate.

Authors:  M Adam; C Fraipont; N Rhazi; M Nguyen-Distèche; B Lakaye; J M Frère; B Devreese; J Van Beeumen; Y van Heijenoort; J van Heijenoort; J M Ghuysen
Journal:  J Bacteriol       Date:  1997-10       Impact factor: 3.490

2.  Interaction of beta-lactamases I and II from Bacillus cereus with semisynthetic cephamycins. Kinetic studies.

Authors:  J Martin Villacorta; P Arriaga; J Laynez; M Menendez
Journal:  Biochem J       Date:  1991-10-01       Impact factor: 3.857

3.  The diversity of the catalytic properties of class A beta-lactamases.

Authors:  A Matagne; A M Misselyn-Bauduin; B Joris; T Erpicum; B Granier; J M Frère
Journal:  Biochem J       Date:  1990-01-01       Impact factor: 3.857

4.  Beta-lactamases as fully efficient enzymes. Determination of all the rate constants in the acyl-enzyme mechanism.

Authors:  H Christensen; M T Martin; S G Waley
Journal:  Biochem J       Date:  1990-03-15       Impact factor: 3.857

5.  A point mutation leads to altered product specificity in beta-lactamase catalysis.

Authors:  E R Lewis; K M Winterberg; A L Fink
Journal:  Proc Natl Acad Sci U S A       Date:  1997-01-21       Impact factor: 11.205

6.  Trapping the acyl-enzyme intermediate in beta-lactamase I catalysis.

Authors:  S J Cartwright; A K Tan; A L Fink
Journal:  Biochem J       Date:  1989-11-01       Impact factor: 3.857

7.  Kinetic properties of the Bacillus licheniformis penicillin-binding proteins.

Authors:  S Lepage; M Galleni; B Lakaye; B Joris; I Thamm; J M Frere
Journal:  Biochem J       Date:  1995-07-01       Impact factor: 3.857

8.  Mutations in ponA, the gene encoding penicillin-binding protein 1, and a novel locus, penC, are required for high-level chromosomally mediated penicillin resistance in Neisseria gonorrhoeae.

Authors:  Patricia A Ropp; Mei Hu; Melanie Olesky; Robert A Nicholas
Journal:  Antimicrob Agents Chemother       Date:  2002-03       Impact factor: 5.191

9.  Penicillin-binding protein 2x of Streptococcus pneumoniae: enzymic activities and interactions with beta-lactams.

Authors:  M Jamin; C Damblon; S Millier; R Hakenbeck; J M Frère
Journal:  Biochem J       Date:  1993-06-15       Impact factor: 3.857

10.  Site-directed mutagenesis of beta-lactamase I. Single and double mutants of Glu-166 and Lys-73.

Authors:  R M Gibson; H Christensen; S G Waley
Journal:  Biochem J       Date:  1990-12-15       Impact factor: 3.857
  10 in total

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