Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Vasoactive intestinal polypeptide: specific binding to rat brain membranes.

Literature DB >> 218214

Vasoactive intestinal polypeptide: specific binding to rat brain membranes.

Abstract

The binding of radiolabeled vasoactive intestinal polypeptide (VIP) to rat brain membranes was investigated. Specific binding of 125I-labeled VIP was reversible and saturable (Bmax = 2.2 pmol/g of wet tissue). Brain membranes exhibited a high affinity for 125I-labeled VIP (KD = 1 nM) at a single class of noninteracting sites. Binding of 125I-labeled VIP paralleled its immunohistochemical localization, being enriched in cerebral cortex, hippocampus, striatum, and thalamus, with the notable exception of the hypothalamus, which had low levels of binding. The density of sites was greater in synaptosomal fractions relative to mitochondrial or nuclear fractions. Secretin and partial sequences of it and VIP inhibited binding to brain membranes with an order of potency similar to that found in other systems. The findings suggest the existence of a unique new class of brain receptors.

Entities: Chemical Disease Gene Species

Mesh：

Substances：

Year: 1979 PMID： 218214 PMCID： PMC383009 DOI： 10.1073/pnas.76.2.660

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

44 in total

1. Alteration of large intestinal electrolyte transport by vasoactive intestinal polypeptide in the rat.

Authors: L C Racusen; H J Binder
Journal: Gastroenterology Date: 1977-10 Impact factor: 22.682

Review 2. Regulatory peptides of the hypothalamus.

Authors: W Vale; C Rivier; M Brown
Journal: Annu Rev Physiol Date: 1977 Impact factor: 19.318

3. The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

Authors: E G GRAY; V P WHITTAKER
Journal: J Anat Date: 1962-01 Impact factor: 2.610

4. Specific binding of vasoactive intestinal peptide to brain membranes from the guinea pig.

Authors: P Robberecht; P De Neef; M Lammens; M Deschodt-Lanckman; J P Christophe
Journal: Eur J Biochem Date: 1978-09-15

5. Protein measurement with the Folin phenol reagent.

Authors: O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal: J Biol Chem Date: 1951-11 Impact factor: 5.157

6. [Receptors for vasoactic intestinal peptide (VIP) in human colonic adenocarcinoma membranes: specific binding and stimulation of adenylate cyclase].

Authors: C Dupont; B Amiranoff; M Laburthe; G Rosselin
Journal: C R Acad Hebd Seances Acad Sci D Date: 1978-01-16

7. Vasoactive intestinal peptide: a potent stimulator of adenosine 3':5'-cyclic monophosphate accumulation in gut carcinoma cell lines in culture.

Authors: M Laburthe; M Rousset; C Boissard; G Chevalier; A Zweibaum; G Rosselin
Journal: Proc Natl Acad Sci U S A Date: 1978-06 Impact factor: 11.205

8. Characterization of VIP-sensitive adenylate cyclase in guinea pig brain.

Authors: M Deschodt-Lanckman; P Robberecht; J Christophe
Journal: FEBS Lett Date: 1977-11-01 Impact factor: 4.124

9. Ligand binding studies in the mouse olfactory bulb: identification and characterization of a L-[3H]carnosine binding site.

Authors: J D Hirsch; M Grillo; F L Margolis
Journal: Brain Res Date: 1978-12-15 Impact factor: 3.252

10. Specific benzodiazepine receptors in rat brain characterized by high-affinity (3H)diazepam binding.

Authors: C Braestrup; R F Squires
Journal: Proc Natl Acad Sci U S A Date: 1977-09 Impact factor: 11.205

18 in total

1. Dosage sensitivity intolerance of VIPR2 microduplication is disease causative to manifest schizophrenia-like phenotypes in a novel BAC transgenic mouse model.

Authors: Xinli Tian; Adam Richard; Madison Wynne El-Saadi; Aakriti Bhandari; Brian Latimer; Isabella Van Savage; Kevlyn Holmes; Ronald L Klein; Donard Dwyer; Nicholas E Goeders; X William Yang; Xiao-Hong Lu
Journal: Mol Psychiatry Date: 2019-08-23 Impact factor: 15.992

2. Oxytocin participates on the effects of vasoactive intestinal peptide on food intake and plasma parameters.

Authors: Andressa B Martins; Marcela C Garnica-Siqueira; Dimas A M Zaia; Cássia Thaïs B V Zaia; Ernane T Uchôa
Journal: Mol Cell Biochem Date: 2017-07-27 Impact factor: 3.396

3. Vasoactive intestinal peptide increases intracellular calcium in astroglia: synergism with alpha-adrenergic receptors.

Authors: A Fatatis; L A Holtzclaw; R Avidor; D E Brenneman; J T Russell
Journal: Proc Natl Acad Sci U S A Date: 1994-03-15 Impact factor: 11.205

4. Proceedings of the joint meeting of the Scandinavian and British Pharmacological Societies. Stockholm--Sweden. 5th and 6th July, 1982.

Authors:
Journal: Br J Pharmacol Date: 1982-09 Impact factor: 8.739

5. Functional role for vasoactive intestinal polypeptide in the caudate nucleus: a 2-deoxy[14C]glucose investigation.

Authors: J McCulloch; P A Kelly; R Uddman; L Edvinsson
Journal: Proc Natl Acad Sci U S A Date: 1983-03 Impact factor: 11.205

6. Vasoactive intestinal polypeptide induces glycogenolysis in mouse cortical slices: a possible regulatory mechanism for the local control of energy metabolism.

Authors: P J Magistretti; J H Morrison; W J Shoemaker; V Sapin; F E Bloom
Journal: Proc Natl Acad Sci U S A Date: 1981-10 Impact factor: 11.205

10. Vasoactive intestinal polypeptide acts synergistically with norepinephrine to depress spontaneous discharge rate in cerebral cortical neurons.

Authors: A Ferron; G R Siggins; F E Bloom
Journal: Proc Natl Acad Sci U S A Date: 1985-12 Impact factor: 11.205