Literature DB >> 2297398

Vasoactive intestinal peptide stimulates melatonin release from perifused pineal glands of rats.

V Simonneaux1, A Ouichou, P Pévet.   

Abstract

The rat pineal gland is known to release melatonin in response to noradrenergic stimulation. The effect of vasoactive intestinal peptide (VIP), one of the neuropeptides present in the pineal, was examined on perifused rat pineal glands. VIP stimulated melatonin release with a dose-dependent effect above 10(-7) M. In regard of kinetic characteristics, the pattern of melatonin release after VIP stimulation was similar to that after isoproterenol stimulation. 10(-6) M VIP-stimulated melatonin release was not altered when the pineal glands were treated with 10(-5) M propranolol (a beta-adrenergic antagonist) or 10(-5) M prazosin (an alpha 1-adrenergic antagonist). Thus VIP has a noradrenergic-independent effect on melatonin secretion. Conversely, this VIP effect is greatly inhibited by the specific action of a VIPergic antagonist. This suggests that VIP acts on melatonin synthesis through its own binding sites. This study demonstrates that melatonin secretion from rat pineal glands may be elicited through a VIPergic system which is independent of the well-known noradrenergic system.

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Year:  1990        PMID： 2297398     DOI： 10.1007/bf01251002

Source DB:  PubMed          Journal:  J Neural Transm Gen Sect


  27 in total

1.  Distribution and origins of substance P (SP)-, calcitonin gene-related peptide (CGRP)-, vasoactive intestinal polypeptide (VIP)- and neuropeptide Y (NPY)-containing nerve fibers in the pineal gland of gerbils.

Authors:  Y Shiotani; M Yamano; S Shiosaka; P C Emson; C J Hillyard; S Girgis; I MacIntyre
Journal:  Neurosci Lett       Date:  1986-10-08       Impact factor: 3.046

2.  Vasoactive intestinal polypeptide: specific binding to rat brain membranes.

Authors:  D P Taylor; C B Pert
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

3.  Melatonin metabolism: neural regulation of pineal serotonin: acetyl coenzyme A N-acetyltransferase activity.

Authors:  D C Klein; J L Weller; R Y Moore
Journal:  Proc Natl Acad Sci U S A       Date:  1971-12       Impact factor: 11.205

4.  Isolation from porcine-intestinal wall of a vasoactive octacosapeptide related to secretin and to glucagon.

Authors:  S I Said; V Mutt
Journal:  Eur J Biochem       Date:  1972-07-13

5.  Direct radioimmunoassay for melatonin in plasma.

Authors:  S Fraser; P Cowen; M Franklin; C Franey; J Arendt
Journal:  Clin Chem       Date:  1983-02       Impact factor: 8.327

Review 6.  The pineal gland: a neurochemical transducer.

Authors:  J Axelrod
Journal:  Science       Date:  1974-06-28       Impact factor: 47.728

7.  Oxytocin- and vasopressin-immunoreactive nerve fibers in the pineal gland of the hedgehog, Erinaceus europaeus L.

Authors:  F Nürnberger; H W Korf
Journal:  Cell Tissue Res       Date:  1981       Impact factor: 5.249

8.  Vasopressin- and oxytocin-containing fibres in the pineal gland and subcommissural organ of the rat.

Authors:  R M Buijs; P Pévet
Journal:  Cell Tissue Res       Date:  1980       Impact factor: 5.249

9.  Light and agonists alter pineal N-acetyltransferase induction by vasoactive intestinal polypeptide.

Authors:  A Yuwiler
Journal:  Science       Date:  1983-06-03       Impact factor: 47.728

10.  Catecholaminergic control of alpha-melanocyte-stimulating hormone (alpha MSH) release by frog neurointermediate lobe in vitro: evidence for direct stimulation of alpha MSH release by thyrotropin-releasing hormone.

Authors:  M C Tonon; P Leroux; M E Stoeckel; S Jegou; G Pelletier; H Vaudry
Journal:  Endocrinology       Date:  1983-01       Impact factor: 4.736
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  6 in total

1.  Immunocytochemical and circadian biochemical analysis of neuroactive amino acids in the pineal gland of the rat: effect of superior cervical ganglionectomy.

Authors:  J A McNulty; L Kus; O P Ottersen
Journal:  Cell Tissue Res       Date:  1992-09       Impact factor: 5.249

2.  Effects of melatonin administration on intestinal adaptive response after massive bowel resection in rats.

Authors:  Hulya Ozturk; Hayrettin Oztürk; Yusuf Yagmur; Ali Kemal Uzunlar
Journal:  Dig Dis Sci       Date:  2006-02       Impact factor: 3.199

3.  In vitro effects of putative neurotransmitters on synaptic ribbon numbers and N-acetyltransferase activity in the rat pineal gland.

Authors:  B B Gupta; A Seidel; R Spessert; W Büttner; N Klauke; J Spanier; A Weber; D Ziemer; L Vollrath
Journal:  J Neural Transm Gen Sect       Date:  1992

Review 4.  Melatonin and the skeleton.

Authors:  A K Amstrup; T Sikjaer; L Mosekilde; L Rejnmark
Journal:  Osteoporos Int       Date:  2013-05-29       Impact factor: 4.507

5.  The presence of opioidergic pinealocytes in the pineal gland of the European hamster (Cricetus cricetus): an immunocytochemical study.

Authors:  A Coto-Montes; M Masson-Pévet; P Pévet; M Møller
Journal:  Cell Tissue Res       Date:  1994-12       Impact factor: 5.249

6.  Adrenergic and peptidergic control of the regulation of cAMP efflux and melatonin secretion from perifused rat pineal gland.

Authors:  Z Rekasi; N Sule; V Csernus; B Mess
Journal:  Endocrine       Date:  1998-08       Impact factor: 3.925
  6 in total

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