Literature DB >> 28752412

Oxytocin participates on the effects of vasoactive intestinal peptide on food intake and plasma parameters.

Andressa B Martins1, Marcela C Garnica-Siqueira1, Dimas A M Zaia2, Cássia Thaïs B V Zaia3, Ernane T Uchôa4.   

Abstract

Vasoactive intestinal peptide (VIP) is a neurotransmitter with anorectic effect that acts in the hypothalamus to regulate food intake. Oxytocin is a neuropeptide produced in the hypothalamus that controls energy homeostasis and has an inhibitory role on food intake. Thus, the present study aims at verifying the role of oxytocin as a mediator of VIP on energy homeostasis. For this purpose, intracerebroventricular microinjection of oxytocin receptor antagonist (vasotocin, OVT) or vehicle (NaCl 0.9%) was carried out in male rats, and after 15 min, VIP or saline was microinjected. After 15 min of the second microinjection, food intake was evaluated or euthanasia was undertaken for blood collection. There was a reduction on food intake after VIP microinjection and the pretreatment with OVT partially reversed this effect. Hyperglycemia was observed after VIP microinjection, and pretreatment with OVT partially blocked this effect. Plasma corticosterone concentration was significantly increased after VIP or OVT. Plasma levels of free fatty acids were decreased by VIP, but not when VIP was microinjected after OVT. Thus, OVT partially reversed VIP-induced hypophagia and changes on plasma metabolic parameters, suggesting a role for oxytocin as a mediator of VIP effects on energy homeostasis.

Entities:  

Keywords:  Corticosterone; Free fatty acids; Glycemia; VIP; Vasotocin

Mesh：

Substances：

Year:  2017        PMID： 28752412     DOI： 10.1007/s11010-017-3106-x

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  40 in total

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Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-03-24       Impact factor: 3.619

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Journal:  Endocrinology       Date:  1991-08       Impact factor: 4.736

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Journal:  Neurosci Lett       Date:  1985-05-14       Impact factor: 3.046

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Journal:  Physiol Behav       Date:  1990-12

6.  Mechanisms involved in the regulation of free fatty acid release from isolated human fat cells by acylation-stimulating protein and insulin.

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Journal:  J Biol Chem       Date:  1999-06-25       Impact factor: 5.157

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Journal:  Peptides       Date:  1989 Mar-Apr       Impact factor: 3.750

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Authors:  Greisa Vila; Michaela Riedl; Michael Resl; Aart Jan van der Lely; Leo J Hofland; Martin Clodi; Anton Luger
Journal:  J Endocrinol       Date:  2009-07-08       Impact factor: 4.286

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Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

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Authors:  Yuko Maejima; Yusaku Iwasaki; Yui Yamahara; Misato Kodaira; Udval Sedbazar; Toshihiko Yada
Journal:  Aging (Albany NY)       Date:  2011-12       Impact factor: 5.682
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  1 in total

1.  Adrenalectomy impairs vasoactive intestinal peptide-induced changes in food intake and plasma parameters.

Authors:  Marcela Cristina Garnica-Siqueira; Andressa Bussetti Martins; Larissa Rugila Dos Stopa; Camila Franciele de Souza; Dimas Augusto Morozin Zaia; Cristiane Mota Leite; Cássia Thaïs Bussamra Vieira Zaia; Ernane Torres Uchôa
Journal:  Endocrine       Date:  2019-07-19       Impact factor: 3.633
  1 in total

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