Literature DB >> 17950667

Food-borne trematodiasis: current chemotherapy and advances with artemisinins and synthetic trioxolanes.

Jennifer Keiser1, Jürg Utzinger.   

Abstract

Over 40 million people are infected with food-borne trematodes and 750 million are at risk of food-borne trematodiasis, and yet this tropical disease is neglected. The current arsenal for the treatment and control of food-borne trematodiasis comprises praziquantel and triclabendazole, which were developed 20-30 years ago. The safety, therapeutic profiles and concern about resistance of these two drugs are summarized here. Recent advances with the artemisinins, which are best known for their antimalarial and antischistosomal properties, and the synthetic trioxolanes in different trematode-rodent models are reviewed. Lastly, prospects for the development of a safe, efficacious, inexpensive and broad-spectrum trematocidal drug are considered.

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Year:  2007        PMID： 17950667     DOI： 10.1016/j.pt.2007.07.012

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  43 in total

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Authors:  Qingjie Zhao; Mireille Vargas; Yuxiang Dong; Lin Zhou; Xiaofang Wang; Kamaraj Sriraghavan; Jennifer Keiser; Jonathan L Vennerstrom
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Journal:  Parasitol Res       Date:  2017-01-26       Impact factor: 2.289

3.  The activity of dispiro peroxides against Fasciola hepatica.

Authors:  Xiaofang Wang; Qingjie Zhao; Mireille Vargas; Yuxiang Dong; Kamaraj Sriraghavan; Jennifer Keiser; Jonathan L Vennerstrom
Journal:  Bioorg Med Chem Lett       Date:  2011-07-19       Impact factor: 2.823

Review 4.  New insight into praziquantel against various developmental stages of schistosomes.

Authors:  Wei Wu; Wei Wang; Yi-Xin Huang
Journal:  Parasitol Res       Date:  2011-10-08       Impact factor: 2.289

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Authors:  Leonore Lovis; Tippi K Mak; Khampheng Phongluxa; Phonepasong Soukhathammavong; Somphou Sayasone; Kongsap Akkhavong; Peter Odermatt; Jennifer Keiser; Ingrid Felger
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9.  In vitro and in vivo treatments of echinococcus protoscoleces and metacestodes with artemisinin and artemisinin derivatives.

Authors:  Martin Spicher; Carole Roethlisberger; Catharina Lany; Britta Stadelmann; Jennifer Keiser; Luis M Ortega-Mora; Bruno Gottstein; Andrew Hemphill
Journal:  Antimicrob Agents Chemother       Date:  2008-07-14       Impact factor: 5.191

10.  Rapid identification of paragonimiasis foci by lay informants in Lao People's Democratic Republic.

Authors:  Peter Odermatt; Duong Veasna; Wei Zhang; Nanthasane Vannavong; Souraxay Phrommala; Shigehisa Habe; Hubert Barennes; Michel Strobel
Journal:  PLoS Negl Trop Dis       Date:  2009-09-22
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