Literature DB >> 26666940

Emergence of cfr-Mediated Linezolid Resistance in a Methicillin-Resistant Staphylococcus aureus Epidemic Clone Isolated from Patients with Cystic Fibrosis.

Juan de Dios Caballero1, María Dolores Pastor2, Ana Vindel3, Luis Máiz4, Genoveva Yagüe5, Carme Salvador5, Marta Cobo6, María-Isabel Morosini1, Rosa del Campo7, Rafael Cantón1.   

Abstract

Resistance to linezolid (LZD) in methicillin-resistant Staphylococcus aureus (MRSA) isolates from patients with cystic fibrosis (CF) is due mainly to ribosomal mutations. We report on four CF patients with LZD-resistant MRSA bronchopulmonary infections by strains carrying the cfr gene. Strains from one patient also harbored the G2576U mutation (23S rRNA) and the G139R substitution (L3 protein). All strains belonged to the epidemic clone ST125 MRSA IVc. Our results support the monitoring of LZD resistance emergence in CF and non-CF MRSA isolates.
Copyright © 2016, American Society for Microbiology. All Rights Reserved.

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Year:  2015        PMID： 26666940      PMCID： PMC4775957          DOI： 10.1128/AAC.02067-15

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  27 in total

Review 1.  Resistance to linezolid caused by modifications at its binding site on the ribosome.

Authors:  Katherine S Long; Birte Vester
Journal:  Antimicrob Agents Chemother       Date:  2011-12-05       Impact factor: 5.191

2.  Emergence of a mutL mutation causing multilocus sequence typing-pulsed-field gel electrophoresis discrepancy among Pseudomonas aeruginosa isolates from a cystic fibrosis patient.

Authors:  María García-Castillo; Luis Máiz; María-Isabel Morosini; Mercedes Rodríguez-Baños; Lucrecia Suarez; Ana Fernández-Olmos; Fernando Baquero; Rafael Cantón; Rosa del Campo
Journal:  J Clin Microbiol       Date:  2012-02-08       Impact factor: 5.948

3.  Linezolid-resistant Staphylococcus aureus strain 1128105, the first known clinical isolate possessing the cfr multidrug resistance gene.

Authors:  Jeffrey B Locke; Douglas E Zuill; Caitlyn R Scharn; Jennifer Deane; Daniel F Sahm; Gerald A Denys; Richard V Goering; Karen J Shaw
Journal:  Antimicrob Agents Chemother       Date:  2014-08-25       Impact factor: 5.191

4.  Detection of linezolid-resistant Staphylococcus aureus with 23S rRNA and novel L4 riboprotein mutations in a cystic fibrosis patient in Spain.

Authors:  Federico Román; Carolina Roldán; Pilar Trincado; Carmen Ballesteros; Concepción Carazo; Ana Vindel
Journal:  Antimicrob Agents Chemother       Date:  2013-03-04       Impact factor: 5.191

Review 5.  Update on methicillin-resistant Staphylococcus aureus in cystic fibrosis.

Authors:  Elliott C Dasenbrook
Journal:  Curr Opin Pulm Med       Date:  2011-11       Impact factor: 3.155

6.  Association between respiratory tract methicillin-resistant Staphylococcus aureus and survival in cystic fibrosis.

Authors:  Elliott C Dasenbrook; William Checkley; Christian A Merlo; Michael W Konstan; Noah Lechtzin; Michael P Boyle
Journal:  JAMA       Date:  2010-06-16       Impact factor: 56.272

7.  Presence of methicillin resistant Staphylococcus aureus in respiratory cultures from cystic fibrosis patients is associated with lower lung function.

Authors:  Clement L Ren; Wayne J Morgan; Michael W Konstan; Michael S Schechter; Jeffrey S Wagener; Kathryn A Fisher; Warren E Regelmann
Journal:  Pediatr Pulmonol       Date:  2007-06

8.  Spread of invasive Spanish Staphylococcus aureus spa-type t067 associated with a high prevalence of the aminoglycoside-modifying enzyme gene ant(4')-Ia and the efflux pump genes msrA/msrB.

Authors:  María Pérez-Vázquez; Ana Vindel; Carmen Marcos; Jesús Oteo; Oscar Cuevas; Pilar Trincado; Verónica Bautista; Hajo Grundmann; José Campos
Journal:  J Antimicrob Chemother       Date:  2008-10-23       Impact factor: 5.790

9.  Emergence of linezolid-resistant Staphylococcus aureus during treatment of pulmonary infection in a patient with cystic fibrosis.

Authors:  Ana C Gales; Hélio S Sader; Soraya S Andrade; Larissa Lutz; Adão Machado; Afonso L Barth
Journal:  Int J Antimicrob Agents       Date:  2006-03-09       Impact factor: 5.283

10.  Resistance to linezolid in a methicillin-susceptible Staphylococcus aureus clinical isolate without previous exposure to oxazolidinones.

Authors:  Immaculada Quiles-Melero; Adela García-Perea; Manuela de Pablos; Rosa Gómez-Gil; Jesús Mingorance
Journal:  Int J Med Microbiol       Date:  2012-05-09       Impact factor: 3.473
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  12 in total

1.  Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus.

Authors:  Kwaku Kyei-Baffour; Haroon Mohammad; Mohamed N Seleem; Mingji Dai
Journal:  Bioorg Med Chem       Date:  2019-03-19       Impact factor: 3.641

2.  Pharmacokinetics of Telavancin in Adult Patients with Cystic Fibrosis during Acute Pulmonary Exacerbation.

Authors:  James M Kidd; Colleen M Sakon; Louise-Marie Oleksiuk; Jeffrey J Cies; Rebecca S Pettit; David P Nicolau; Joseph L Kuti
Journal:  Antimicrob Agents Chemother       Date:  2019-12-20       Impact factor: 5.191

3.  An aryl isonitrile compound with an improved physicochemical profile that is effective in two mouse models of multidrug-resistant Staphylococcus aureus infection.

Authors:  Haroon Mohammad; Kwaku Kyei-Baffour; Nader S Abutaleb; Mingji Dai; Mohamed N Seleem
Journal:  J Glob Antimicrob Resist       Date:  2019-04-30       Impact factor: 4.035

4.  In-Host Emergence of Linezolid Resistance in a Complex Pattern of Toxic Shock Syndrome Toxin-1-Positive Methicillin-Resistant Staphylococcus aureus Colonization in Siblings with Cystic Fibrosis.

Authors:  Agathe Boudet; Alexandre Jay; Catherine Dunyach-Remy; Raphaël Chiron; Jean-Philippe Lavigne; Hélène Marchandin
Journal:  Toxins (Basel)       Date:  2021-04-28       Impact factor: 4.546

Review 5.  Streptomyces as a Prominent Resource of Future Anti-MRSA Drugs.

Authors:  Hefa Mangzira Kemung; Loh Teng-Hern Tan; Tahir Mehmood Khan; Kok-Gan Chan; Priyia Pusparajah; Bey-Hing Goh; Learn-Han Lee
Journal:  Front Microbiol       Date:  2018-09-24       Impact factor: 5.640

6.  Induction of Phage-Specific Antibodies by Two Therapeutic Staphylococcal Bacteriophages Administered per os.

Authors:  Joanna Majewska; Zuzanna Kaźmierczak; Karolina Lahutta; Dorota Lecion; Aleksander Szymczak; Paulina Miernikiewicz; Jarosław Drapała; Marek Harhala; Karolina Marek-Bukowiec; Natalia Jędruchniewicz; Barbara Owczarek; Andrzej Górski; Krystyna Dąbrowska
Journal:  Front Immunol       Date:  2019-11-14       Impact factor: 7.561

7.  Mobile Oxazolidinone Resistance Genes in Gram-Positive and Gram-Negative Bacteria.

Authors:  Stefan Schwarz; Wanjiang Zhang; Xiang-Dang Du; Henrike Krüger; Andrea T Feßler; Shizhen Ma; Yao Zhu; Congming Wu; Jianzhong Shen; Yang Wang
Journal:  Clin Microbiol Rev       Date:  2021-06-02       Impact factor: 50.129

Review 8.  New Is Old, and Old Is New: Recent Advances in Antibiotic-Based, Antibiotic-Free and Ethnomedical Treatments against Methicillin-Resistant Staphylococcus aureus Wound Infections.

Authors:  Jian-Lin Dou; Yi-Wei Jiang; Jun-Qiu Xie; Xiao-Gang Zhang
Journal:  Int J Mol Sci       Date:  2016-04-25       Impact factor: 5.923

9.  Real-world daptomycin use across wide geographical regions: results from a pooled analysis of CORE and EU-CORE.

Authors:  R Andrew Seaton; Armando Gonzalez-Ruiz; Kerry O Cleveland; Kimberly A Couch; Rashidkhan Pathan; Kamal Hamed
Journal:  Ann Clin Microbiol Antimicrob       Date:  2016-03-15       Impact factor: 3.944

10.  First Case of Staphylococci Carrying Linezolid Resistance Genes from Laryngological Infections in Poland.

Authors:  Michał Michalik; Maja Kosecka-Strojek; Mariola Wolska; Alfred Samet; Adrianna Podbielska-Kubera; Jacek Międzobrodzki
Journal:  Pathogens       Date:  2021-03-13
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