AIM: To evaluate the effects of systemic azithromycin (AZM) as an adjunct to scaling and root planing (SRP) in the treatment of generalized chronic periodontitis (ChP). METHODS:Forty subjects were randomly assigned to receive SRP alone or combined with AZM (500 mg/day) for 5 days (n=20/group). Clinical and microbiological examinations were performed at baseline, 6 months and 1-year post-SRP. Nine plaque samples per subject were analysed by checkerboard DNA-DNA hybridization for 40 bacterial species. Differences between groups were assessed using the Mann-Whitney test and over time using Friedman and Dunn's tests. RESULTS: No statistically significant differences were observed between groups for any parameters evaluated at 1-year post-treatments. Both therapies equally reduced the mean probing depth (PD) (SRP: 3.83 ± 1.92, AZM: 3.45 ± 1.74) and improved the mean clinical attachment (SRP: 2.35 ± 1.70, AZM: 2.68 ± 1.76) in sites with initial PD7 mm (primary outcome variable) between baseline and 1 year. The mean counts and proportions of several periodontal pathogens were reduced, and those of host-beneficial species were increased after treatments. Nonetheless, an important recolonization with red complex species was observed in both groups over the course of the study. CONCLUSION: The data of the present study suggest no adjunctive benefit of AZM in the treatment of generalized ChP.
RCT Entities:
AIM: To evaluate the effects of systemic azithromycin (AZM) as an adjunct to scaling and root planing (SRP) in the treatment of generalized chronic periodontitis (ChP). METHODS: Forty subjects were randomly assigned to receive SRP alone or combined with AZM (500 mg/day) for 5 days (n=20/group). Clinical and microbiological examinations were performed at baseline, 6 months and 1-year post-SRP. Nine plaque samples per subject were analysed by checkerboard DNA-DNA hybridization for 40 bacterial species. Differences between groups were assessed using the Mann-Whitney test and over time using Friedman and Dunn's tests. RESULTS: No statistically significant differences were observed between groups for any parameters evaluated at 1-year post-treatments. Both therapies equally reduced the mean probing depth (PD) (SRP: 3.83 ± 1.92, AZM: 3.45 ± 1.74) and improved the mean clinical attachment (SRP: 2.35 ± 1.70, AZM: 2.68 ± 1.76) in sites with initial PD7 mm (primary outcome variable) between baseline and 1 year. The mean counts and proportions of several periodontal pathogens were reduced, and those of host-beneficial species were increased after treatments. Nonetheless, an important recolonization with red complex species was observed in both groups over the course of the study. CONCLUSION: The data of the present study suggest no adjunctive benefit of AZM in the treatment of generalized ChP.
Authors: Nithya Jagannathan; Aneesha Acharya; Ong Yi Farn; Kar Yan Li; Luigi Nibali; George Pelekos Journal: BMC Oral Health Date: 2019-04-27 Impact factor: 2.757
Authors: Sigmund S Socransky; Anne D Haffajee; Ricardo Teles; Jan L Wennstrom; Jan Lindhe; Anna Bogren; Hatice Hasturk; Thomas van Dyke; Xiaoshan Wang; Jo Max Goodson Journal: J Clin Periodontol Date: 2013-05-27 Impact factor: 8.728
Authors: Malene Plejdrup Hansen; Anna M Scott; Amanda McCullough; Sarah Thorning; Jeffrey K Aronson; Elaine M Beller; Paul P Glasziou; Tammy C Hoffmann; Justin Clark; Chris B Del Mar Journal: Cochrane Database Syst Rev Date: 2019-01-18