Antonio Renatus1, Jörg Herrmann2, Antje Schönfelder3, Fabian Schwarzenberger4, Holger Jentsch5. 1. Faculty, Department of Cariology, Endodontology and Periodontology, Centre for Periodontology, University Hospital of Leipzig , Leipzig, Germany . 2. Student, Department of Cariology, Endodontology and Periodontology, Centre for Periodontology, University Hospital of Leipzig , Leipzig, Germany . 3. Student, Department of Psychology, Clinical Research Organization , Leipzig, Germany . 4. Professor, Faculty of Informatics/Mathematics, University of Applied Sciences , Dresden, Germany . 5. Professor, Department of Cariology, Endodontology and Periodontology, Centre for Periodontology, University Hospital of Leipzig , Leipzig, Germany .
Abstract
INTRODUCTION: Over the years, numerous trials have sufficiently documented benefits of adjuvant administration of antibiotics in combination to Scaling and Root Planing (SRP) in treatment of periodontitis. Nevertheless there are justified doubts in respect to antibiotics administration with regard to increasing development of resistances. AIM: The aim of this review study and meta-analysis was to verify a possible benefit of Azithromycin (AZM) as an alternative adjuvant antibiotic in combination with SRP. MATERIALS AND METHODS: Electronic databases (Pubmed) were searched from the earliest point of record until May 2015. A hand search was also conducted. The variables considered in this respect were Probing Depth (PD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and SRP. A meta-analysis containing trials comparing SRP as a sole therapy with SRP and administration of AZM was produced once all of the data obtained had been reviewed. RESULTS: Six randomised clinical trials were accepted into the review and the meta-analysis following the process of trial selection. Meta-analysis revealed larger overall effects by the systemic administration of AZM compared with SRP on their own in terms of PD, CAL, BOP, Plaque-Index and total bacterial load reduction after three and six months. CONCLUSION: The data used in this study revealed that the systemic administration of AZM is beneficial compared with SRP on its own for the treatment of chronic periodontitis.
INTRODUCTION: Over the years, numerous trials have sufficiently documented benefits of adjuvant administration of antibiotics in combination to Scaling and Root Planing (SRP) in treatment of periodontitis. Nevertheless there are justified doubts in respect to antibiotics administration with regard to increasing development of resistances. AIM: The aim of this review study and meta-analysis was to verify a possible benefit of Azithromycin (AZM) as an alternative adjuvant antibiotic in combination with SRP. MATERIALS AND METHODS: Electronic databases (Pubmed) were searched from the earliest point of record until May 2015. A hand search was also conducted. The variables considered in this respect were Probing Depth (PD), Clinical Attachment Level (CAL), Bleeding on Probing (BOP) and SRP. A meta-analysis containing trials comparing SRP as a sole therapy with SRP and administration of AZM was produced once all of the data obtained had been reviewed. RESULTS: Six randomised clinical trials were accepted into the review and the meta-analysis following the process of trial selection. Meta-analysis revealed larger overall effects by the systemic administration of AZM compared with SRP on their own in terms of PD, CAL, BOP, Plaque-Index and total bacterial load reduction after three and six months. CONCLUSION: The data used in this study revealed that the systemic administration of AZM is beneficial compared with SRP on its own for the treatment of chronic periodontitis.
Entities:
Keywords:
Antibiotics; Drug therapy; Periodontal debridement
Authors: C Blandizzi; T Malizia; A Lupetti; D Pesce; M Gabriele; M R Giuca; M Campa; M Del Tacca; S Senesi Journal: J Periodontol Date: 1999-09 Impact factor: 6.993
Authors: T Malizia; M R Tejada; E Ghelardi; S Senesi; M Gabriele; M R Giuca; C Blandizzi; R Danesi; M Campa; M Del Tacca Journal: J Periodontol Date: 1997-12 Impact factor: 6.993
Authors: A J van Winkelhoff; D Herrera; E G Winkel; N Dellemijn-Kippuw; C M Vandenbroucke-Grauls; M Sanz Journal: Ned Tijdschr Tandheelkd Date: 1999-08
Authors: Alex N Haas; Gabriel D de Castro; Tatiana Moreno; Cristiano Susin; Jasim M Albandar; Rui V Oppermann; Cassiano K Rösing Journal: J Clin Periodontol Date: 2008-07-09 Impact factor: 8.728
Authors: Nithya Jagannathan; Aneesha Acharya; Ong Yi Farn; Kar Yan Li; Luigi Nibali; George Pelekos Journal: BMC Oral Health Date: 2019-04-27 Impact factor: 2.757
Authors: B Pretzl; S Sälzer; B Ehmke; U Schlagenhauf; B Dannewitz; H Dommisch; P Eickholz; Y Jockel-Schneider Journal: Clin Oral Investig Date: 2018-10-29 Impact factor: 3.573