Holger F R Jentsch1, Andreas Buchmann2, Abel Friedrich2, Sigrun Eick3. 1. Centre for Periodontology, Department of Cariology, Endodontology and Periodontology, University Hospital of Leipzig, Liebigstr. 12, Haus 1, 04103, Leipzig, Germany. jenh@medizin.uni-leipzig.de. 2. Private dental practice, Weiskirchen, Germany. 3. Department of Periodontology, Laboratory of Oral Microbiology, School of Dental Medicine, University of Bern, Bern, Switzerland.
Abstract
OBJECTIVES: The objective of the present study is to compare the effect of systemic adjunctive use of azithromycin with amoxicillin/metronidazole to scaling and root planing (SRP) in a clinical study. MATERIALS AND METHODS: Data from 60 individuals with chronic periodontitis were evaluated after full-mouth SRP. Antibiotics were given from the first day of SRP, in the test group (n = 29), azithromycin for 3 days and, in the control group (n = 31), amoxicillin/metronidazole for7 days. Probing depth (PD), attachment level (AL), and bleeding on probing (BOP) were recorded at baseline and after 3 and 12 months. Gingival crevicular fluid was analyzed for matrix metalloprotease (MMP)-8 and interleukin (IL)-1beta levels. Subgingival plaque was taken for assessment of the major bacteria associated with periodontitis. RESULTS: In both groups, PD, AL, and BOP were significantly reduced (p < 0.001). A few significant differences between the groups were found; AL and BOP were significantly better in the test than in the control group at the end of the study (p = 0.020 and 0.009). Periodontopathogens were reduced most in the test group. CONCLUSIONS: A noninferiority of the treatment with azithromycin in comparison with amoxicillin/metronidazole can be stated. The administration of azithromycin could be an alternative to the use of amoxicillin/metronidazole adjunctive to SRP in patients with moderate or severe chronic periodontitis; however, a randomized placebo-controlled multicenter study is needed. CLINICAL RELEVANCE: Application of azithromycin as a single antibiotic for 3 days might be considered as an additional adjunctive antibiotic to SRP in selected patients.
RCT Entities:
OBJECTIVES: The objective of the present study is to compare the effect of systemic adjunctive use of azithromycin with amoxicillin/metronidazole to scaling and root planing (SRP) in a clinical study. MATERIALS AND METHODS: Data from 60 individuals with chronic periodontitis were evaluated after full-mouth SRP. Antibiotics were given from the first day of SRP, in the test group (n = 29), azithromycin for 3 days and, in the control group (n = 31), amoxicillin/metronidazole for7 days. Probing depth (PD), attachment level (AL), and bleeding on probing (BOP) were recorded at baseline and after 3 and 12 months. Gingival crevicular fluid was analyzed for matrix metalloprotease (MMP)-8 and interleukin (IL)-1beta levels. Subgingival plaque was taken for assessment of the major bacteria associated with periodontitis. RESULTS: In both groups, PD, AL, and BOP were significantly reduced (p < 0.001). A few significant differences between the groups were found; AL and BOP were significantly better in the test than in the control group at the end of the study (p = 0.020 and 0.009). Periodontopathogens were reduced most in the test group. CONCLUSIONS: A noninferiority of the treatment with azithromycin in comparison with amoxicillin/metronidazole can be stated. The administration of azithromycin could be an alternative to the use of amoxicillin/metronidazole adjunctive to SRP in patients with moderate or severe chronic periodontitis; however, a randomized placebo-controlled multicenter study is needed. CLINICAL RELEVANCE: Application of azithromycin as a single antibiotic for 3 days might be considered as an additional adjunctive antibiotic to SRP in selected patients.
Entities:
Keywords:
Antibiotics; Chronic periodontitis; Cytokines; Periodontopathogens; Scaling and root planing
Authors: Alex N Haas; Gabriel D de Castro; Tatiana Moreno; Cristiano Susin; Jasim M Albandar; Rui V Oppermann; Cassiano K Rösing Journal: J Clin Periodontol Date: 2008-07-09 Impact factor: 8.728
Authors: Manuela Kaufmann; Patrik Lenherr; Clemens Walter; Thomas Thurnheer; Thomas Attin; Daniel B Wiedemeier; Patrick R Schmidlin Journal: Dent J (Basel) Date: 2018-10-20
Authors: Raluca Cosgarea; S Eick; S Jepsen; N B Arweiler; R Juncar; R Tristiu; G E Salvi; C Heumann; A Sculean Journal: Sci Rep Date: 2020-10-01 Impact factor: 4.379
Authors: Sarhang Sarwat Gul; Faraedon Mostafa Zardawi; Ali Abbas Abdulkareem; Muhammad Saad Shaikh; Natheer Hashim Al-Rawi; Muhammad Sohail Zafar Journal: Int J Environ Res Public Health Date: 2022-03-07 Impact factor: 4.614