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Literature DB >> 23446952

Antibacterial and immunomodulatory properties of azithromycin treatment implications for periodontitis.

P M Bartold¹, A H du Bois, S Gannon, D R Haynes, R S Hirsch.

Abstract

Macrolide antibiotics have been found to possess not only antimicrobial properties, but also modulate inflammation. In this review the multi-faceted properties of azithromycin are discussed. Due to the unique anti-inflammatory and antimicrobial properties, macrolides, and especially azithromycin, are currently used for a number of conditions which have both an inflammatory and microbial component. For the same reason, azithromycin may be of value as an adjunct in the management of periodontitis which, although driven by an infectious component, is largely a result of uncontrolled chronic inflammation.

Entities: Chemical Disease

Mesh：

Substances：

Year: 2013 PMID： 23446952 DOI： 10.1007/s10787-012-0165-1

Source DB: PubMed Journal: Inflammopharmacology ISSN： 0925-4692 Impact factor: 4.473

159 in total

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Authors: W Lee Hand; Debra L Hand; Yvonne Vasquez
Journal: Diabetes Res Clin Pract Date: 2006-09-07 Impact factor: 5.602

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Authors: Nidhi Jain; Pin-Chuang Lai; John D Walters
Journal: J Periodontol Date: 2012-02-14 Impact factor: 6.993

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Authors: Masaharu Shinkai; Markus O Henke; Bruce K Rubin
Journal: Pharmacol Ther Date: 2007-12-15 Impact factor: 12.310

9. Subinhibitory concentrations of azithromycin decrease nontypeable Haemophilus influenzae biofilm formation and Diminish established biofilms.

Authors: Timothy D Starner; Joshua D Shrout; Matthew R Parsek; Peter C Appelbaum; GunHee Kim
Journal: Antimicrob Agents Chemother Date: 2007-10-22 Impact factor: 5.191

10. Azithromycin blocks quorum sensing and alginate polymer formation and increases the sensitivity to serum and stationary-growth-phase killing of Pseudomonas aeruginosa and attenuates chronic P. aeruginosa lung infection in Cftr(-/-) mice.

Authors: Nadine Hoffmann; Baoleri Lee; Morten Hentzer; Thomas Bovbjerg Rasmussen; Zhijun Song; Helle Krogh Johansen; Michael Givskov; Niels Høiby
Journal: Antimicrob Agents Chemother Date: 2007-07-09 Impact factor: 5.191

11 in total

1. Disease severity, debridement approach and timing of drug modify outcomes of adjunctive azithromycin in non-surgical management of chronic periodontitis: a multivariate meta-analysis.

Authors: Nithya Jagannathan; Aneesha Acharya; Ong Yi Farn; Kar Yan Li; Luigi Nibali; George Pelekos
Journal: BMC Oral Health Date: 2019-04-27 Impact factor: 2.757

Review 2. Non-surgical periodontal therapy supplemented with systemically administered azithromycin: a systematic review of RCTs.

Authors: Sabrina L Buset; Nicola U Zitzmann; Roland Weiger; Clemens Walter
Journal: Clin Oral Investig Date: 2015-06-12 Impact factor: 3.573

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Authors: Sandra Pacios; Oelisoa Andriankaja; Jun Kang; Maher Alnammary; Jason Bae; Beatriz de Brito Bezerra; Helen Schreiner; Daniel H Fine; Dana T Graves
Journal: Am J Pathol Date: 2013-10-08 Impact factor: 4.307

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Authors: Li-Chao Fan; Jin-Fu Xu
Journal: J Thorac Dis Date: 2014-07 Impact factor: 2.895

5. Azithromycin suppresses P. gingivalis LPS-induced pro-inflammatory cytokine and chemokine production by human gingival fibroblasts in vitro.

Authors: C J Doyle; T R Fitzsimmons; C Marchant; A A S S K Dharmapatni; R Hirsch; P M Bartold
Journal: Clin Oral Investig Date: 2014-05-08 Impact factor: 3.573

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Authors: B Chee; B Park; T Fitzsimmons; A M Coates; P M Bartold
Journal: Clin Oral Investig Date: 2016-02-17 Impact factor: 3.573

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Authors: Mohammad Rafi Khezri; Naime Majidi Zolbanin; Morteza Ghasemnejad-Berenji; Reza Jafari
Journal: Eur J Pharmacol Date: 2021-05-17 Impact factor: 5.195

8. Effects of long-term use of macrolides in patients with non-cystic fibrosis bronchiectasis: a meta-analysis of randomized controlled trials.

Authors: Li-Chao Fan; Hai-Wen Lu; Ping Wei; Xiao-Bin Ji; Shuo Liang; Jin-Fu Xu
Journal: BMC Infect Dis Date: 2015-03-27 Impact factor: 3.090

9. Effect of azithromycin on a red complex polymicrobial biofilm.

Authors: Hwei Sze Ong; Orit Oettinger-Barak; Stuart G Dashper; Ivan B Darby; Kheng H Tan; Eric C Reynolds
Journal: J Oral Microbiol Date: 2017-06-16 Impact factor: 5.474

Review 10. Comparing the Antimicrobial In Vitro Efficacy of Amoxicillin/Metronidazole against Azithromycin-A Systematic Review.

Authors: Manuela Kaufmann; Patrik Lenherr; Clemens Walter; Thomas Thurnheer; Thomas Attin; Daniel B Wiedemeier; Patrick R Schmidlin
Journal: Dent J (Basel) Date: 2018-10-20