Literature DB >> 21769163

Highlighting the Versatility of the Tracerlab Synthesis Modules. Part 1: Fully Automated Production of [F]Labelled Radiopharmaceuticals using a Tracerlab FX(FN).

Xia Shao1, Raphaël Hoareau, Brian G Hockley, Louis J M Tluczek, Bradford D Henderson, Henry C Padgett, Peter J H Scott.   

Abstract

The field of radiochemistry is moving towards exclusive use of automated synthesis modules for production of clinical radiopharmaceutical doses. Such a move comes with many advantages, but also presents radiochemists with the challenge of re-configuring synthesis modules for production of radiopharmaceuticals that require non-conventional radiochemistry whilst maintaining full automation. This review showcases the versatility of the Tracerlab FX(FN) synthesis module by presenting simple, fully automated methods for producing [(18)F]FLT, [(18)F]FAZA, [(18)F]MPPF, [(18)F]FEOBV, [(18)F]sodium fluoride, [(18)F]fluorocholine and [(18)F]SFB.

Entities:  

Year:  2011        PMID： 21769163      PMCID： PMC3137381          DOI： 10.1002/jlcr.1865

Source DB:  PubMed          Journal:  J Labelled Comp Radiopharm        ISSN： 0362-4803            Impact factor:   1.921


  52 in total

1.  P-[18F]-MPPF: a potential radioligand for PET studies of 5-HT1A receptors in humans.

Authors:  C Y Shiue; G G Shiue; P D Mozley; M P Kung; Z P Zhuang; H J Kim; H F Kung
Journal:  Synapse       Date:  1997-02       Impact factor: 2.562

2.  A new precursor for the radiosynthesis of [18F]FLT.

Authors:  S J Martin; J A Eisenbarth; U Wagner-Utermann; W Mier; M Henze; H Pritzkow; U Haberkorn; M Eisenhut
Journal:  Nucl Med Biol       Date:  2002-02       Impact factor: 2.408

3.  Synthesis and evaluation of 18F-labeled choline as an oncologic tracer for positron emission tomography: initial findings in prostate cancer.

Authors:  T R DeGrado; R E Coleman; S Wang; S W Baldwin; M D Orr; C N Robertson; T J Polascik; D T Price
Journal:  Cancer Res       Date:  2001-01-01       Impact factor: 12.701

4.  Hypoxia-specific tumor imaging with 18F-fluoroazomycin arabinoside.

Authors:  Morand Piert; Hans-Jürgen Machulla; Maria Picchio; Gerald Reischl; Sybille Ziegler; Piyush Kumar; Hans-Jürgen Wester; Roswitha Beck; Alexander J B McEwan; Leonard I Wiebe; Markus Schwaiger
Journal:  J Nucl Med       Date:  2005-01       Impact factor: 10.057

5.  [18F]fluoromethyl triflate, a novel and reactive [18F]fluoromethylating agent: preparation and application to the on-column preparation of [18F]fluorocholine.

Authors:  Ren Iwata; Claudio Pascali; Anna Bogni; Shozo Furumoto; Kazunori Terasaki; Kazuhiko Yanai
Journal:  Appl Radiat Isot       Date:  2002-09       Impact factor: 1.513

6.  Neuronal loss in the pedunculopontine tegmental nucleus in Parkinson disease and in progressive supranuclear palsy.

Authors:  E C Hirsch; A M Graybiel; C Duyckaerts; F Javoy-Agid
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

7.  An automated method for preparation of [(18)F]sodium fluoride for injection, USP to address the technetium-99m isotope shortage.

Authors:  Brian G Hockley; Peter J H Scott
Journal:  Appl Radiat Isot       Date:  2009-08-28       Impact factor: 1.513

8.  A fully automated one-pot synthesis of [carbonyl-11C]WAY-100635 for clinical PET applications.

Authors:  Raisa N Krasikova; Jan Andersson; Phong Truong; Sangram Nag; Evgeny V Shchukin; Christer Halldin
Journal:  Appl Radiat Isot       Date:  2008-07-22       Impact factor: 1.513

9.  A simple modification of GE tracerlab FX C Pro for rapid sequential preparation of [11C]carfentanil and [11C]raclopride.

Authors:  Xia Shao; Michael R Kilbourn
Journal:  Appl Radiat Isot       Date:  2008-12-24       Impact factor: 1.513

10.  Positron emission tomography imaging of (2R,3R)-5-[(18)F]fluoroethoxybenzovesamicol in rat and monkey brain: a radioligand for the vesicular acetylcholine transporter.

Authors:  Michael R Kilbourn; Brian Hockley; Lihsueh Lee; Phillip Sherman; Carole Quesada; Kirk A Frey; Robert A Koeppe
Journal:  Nucl Med Biol       Date:  2009-05-08       Impact factor: 2.408
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  41 in total

1.  Clinical markers for identifying cholinergic deficits in Parkinson's disease.

Authors:  Martijn L T M Müller; Nicolaas I Bohnen; Vikas Kotagal; Peter J H Scott; Robert A Koeppe; Kirk A Frey; Roger L Albin
Journal:  Mov Disord       Date:  2014-11-12       Impact factor: 10.338

Review 2.  Positron emission tomography molecular imaging in late-life depression.

Authors:  Kentaro Hirao; Gwenn S Smith
Journal:  J Geriatr Psychiatry Neurol       Date:  2014-01-05       Impact factor: 2.680

3.  Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson disease.

Authors:  Nicolaas I Bohnen; Vikas Kotagal; Martijn L T M Müller; Robert A Koeppe; Peter J H Scott; Roger L Albin; Kirk A Frey; Myria Petrou
Journal:  Parkinsonism Relat Disord       Date:  2014-10-15       Impact factor: 4.891

4.  Extra-nigral pathological conditions are common in Parkinson's disease with freezing of gait: an in vivo positron emission tomography study.

Authors:  Nicolaas I Bohnen; Kirk A Frey; Stephanie Studenski; Vikas Kotagal; Robert A Koeppe; Gregory M Constantine; Peter J H Scott; Roger L Albin; Martijn L T M Müller
Journal:  Mov Disord       Date:  2014-06-07       Impact factor: 10.338

5.  Thalamic cholinergic innervation and postural sensory integration function in Parkinson's disease.

Authors:  Martijn L T M Müller; Roger L Albin; Vikas Kotagal; Robert A Koeppe; Peter J H Scott; Kirk A Frey; Nicolaas I Bohnen
Journal:  Brain       Date:  2013-09-20       Impact factor: 13.501

6.  Evaluation of [(11)C]N-Methyl Lansoprazole as a Radiopharmaceutical for PET Imaging of Tau Neurofibrillary Tangles.

Authors:  Xia Shao; Garrett M Carpenter; Timothy J Desmond; Phillip Sherman; Carole A Quesada; Maria Fawaz; Allen F Brooks; Michael R Kilbourn; Roger L Albin; Kirk A Frey; Peter J H Scott
Journal:  ACS Med Chem Lett       Date:  2012-09-25       Impact factor: 4.345

7.  Mentally stimulating activities associate with better cognitive performance in Parkinson disease.

Authors:  Jeffrey L B Bohnen; Martijn L T M Müller; Jacob Haugen; Nicolaas I Bohnen
Journal:  J Neural Transm (Vienna)       Date:  2017-07-19       Impact factor: 3.575

8.  Striatal and Cortical β-Amyloidopathy and Cognition in Parkinson's Disease.

Authors:  Neha Shah; Kirk A Frey; Martijn L T M Müller; Myria Petrou; Vikas Kotagal; Robert A Koeppe; Peter J H Scott; Roger L Albin; Nicolaas I Bohnen
Journal:  Mov Disord       Date:  2015-09-18       Impact factor: 10.338

9.  Intranasal Opioid Administration in Rhesus Monkeys: PET Imaging and Antinociception.

Authors:  Phillip A Saccone; Angela M Lindsey; Robert A Koeppe; Kathy A Zelenock; Xia Shao; Phillip Sherman; Carole A Quesada; James H Woods; Peter J H Scott
Journal:  J Pharmacol Exp Ther       Date:  2016-09-13       Impact factor: 4.030

10.  Non-exercise physical activity attenuates motor symptoms in Parkinson disease independent from nigrostriatal degeneration.

Authors:  Jonathan Snider; Martijn L T M Müller; Vikas Kotagal; Robert A Koeppe; Peter J H Scott; Kirk A Frey; Roger L Albin; Nicolaas I Bohnen
Journal:  Parkinsonism Relat Disord       Date:  2015-08-28       Impact factor: 4.891
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