A simple modification of GE tracerlab FX C Pro for rapid sequential preparation of [11C]carfentanil and [11C]raclopride.

A simple modification of the GE Tracerlab FX C Pro system which enabled performance of both solvent capture (loop method) and conventional solution phase [(11)C]methylation in the same module is described. By the quick setup and automated method, [(11)C]carfentanil and [(11)C]raclopride could be prepared in rapid succession without opening the hot cell. The radiochemical yields were over 40% and 30% (decay-corrected and based on [(11)C]methyl iodide) for [(11)C]carfentanil and [(11)C]raclopride, respectively. The radiochemical purities were greater than 95% and specific activities over 5 Ci/mmol for both tracers. The modification is extremely easy and can be utilized for multiple syntheses of other (11)C-labeled radiopharmaceuticals in a fast and reliable manner.