Literature DB >> 18715791

A fully automated one-pot synthesis of [carbonyl-11C]WAY-100635 for clinical PET applications.

Raisa N Krasikova1, Jan Andersson, Phong Truong, Sangram Nag, Evgeny V Shchukin, Christer Halldin.   

Abstract

A fully automated synthesis of the important 5HT(1A) receptor radioligand, [carbonyl-(11)C]WAY-100635 (I), was developed based on the optimized one-pot "wet" synthesis procedure. A modern automated apparatus was constructed from commercially available components and operated via LabView software. In average, (906+/-525)MBq (n=94) of (I) was obtained from 40 min bombardment at 50 microA beam current within 50 min synthesis time. The specific radioactivity (SA) at the time of injection was (50.5+/-29.3)GBq/mumol (n=94).

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Year:  2008        PMID： 18715791     DOI： 10.1016/j.apradiso.2008.07.008

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  6 in total

1.  Highlighting the Versatility of the Tracerlab Synthesis Modules. Part 1: Fully Automated Production of [F]Labelled Radiopharmaceuticals using a Tracerlab FX(FN).

Authors:  Xia Shao; Raphaël Hoareau; Brian G Hockley; Louis J M Tluczek; Bradford D Henderson; Henry C Padgett; Peter J H Scott
Journal:  J Labelled Comp Radiopharm       Date:  2011-05-30       Impact factor: 1.921

2.  Synthesis, in vitro and in vivo evaluation of 11C-O-methylated arylpiperazines as potential serotonin 1A (5-HT1A) receptor antagonist radiotracers.

Authors:  Vidya Narayanaswami; Junchao Tong; Ferdinando Fiorino; Beatrice Severino; Rosa Sparaco; Elisa Magli; Flavia Giordano; Peter M Bloomfield; Jaya Prabhakaran; J John Mann; Neil Vasdev; Kenneth Dahl; J S Dileep Kumar
Journal:  EJNMMI Radiopharm Chem       Date:  2020-05-19

3.  Recent progress in [11 C]carbon dioxide ([11 C]CO2 ) and [11 C]carbon monoxide ([11 C]CO) chemistry.

Authors:  Carlotta Taddei; Antony D Gee
Journal:  J Labelled Comp Radiopharm       Date:  2018-02-05       Impact factor: 1.921

4.  Reliable set-up for in-loop ¹¹C-carboxylations using Grignard reactions for the preparation of [carbonyl-¹¹C]WAY-100635 and [¹¹C]-(+)-PHNO.

Authors:  Christina Rami-Mark; Johanna Ungersboeck; Daniela Haeusler; Lukas Nics; Cecile Philippe; Markus Mitterhauser; Matthaeus Willeit; Rupert Lanzenberger; Georgios Karanikas; Wolfgang Wadsak
Journal:  Appl Radiat Isot       Date:  2013-08-03       Impact factor: 1.513

Review 5.  [11C]Carbon monoxide: advances in production and application to PET radiotracer development over the past 15 years.

Authors:  Carlotta Taddei; Victor W Pike
Journal:  EJNMMI Radiopharm Chem       Date:  2019-09-18

6.  Use of 55 PET radiotracers under approval of a Radioactive Drug Research Committee (RDRC).

Authors:  Isaac M Jackson; So Jeong Lee; Alexandra R Sowa; Melissa E Rodnick; Laura Bruton; Mara Clark; Sean Preshlock; Jill Rothley; Virginia E Rogers; Leslie E Botti; Bradford D Henderson; Brian G Hockley; Jovany Torres; David M Raffel; Allen F Brooks; Kirk A Frey; Michael R Kilbourn; Robert A Koeppe; Xia Shao; Peter J H Scott
Journal:  EJNMMI Radiopharm Chem       Date:  2020-11-11
  6 in total

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